ABSTRACT
A method for prevention of inflammatory complications of mandibular fractures making use of insulating polymer-based bioactive film was studied on 48 mice. Antibacterial and osteoregeneratory activities of the therapeutic film were assessed.
Subject(s)
Biocompatible Materials/therapeutic use , Mandibular Fractures/complications , Osteomyelitis/prevention & control , Polymers/therapeutic use , Animals , Biocompatible Materials/adverse effects , Materials Testing/economics , Mice , Models, Animal , Osteogenesis/physiology , Osteomyelitis/etiology , Polymers/adverse effectsABSTRACT
Magnetic semiconductors such as Cu(x)Mg(1-x)O, which are perspective materials for high-temperature superconductivity have been studied by EXAFS. The new technique of obtaining information from EXAFS-data has been described. It is based on the special iterative algorithm of solving an inverse ill-posed problem on the determination the partial pair correlation functions (pPCFs). Bond lengths of the nearest neighbours have been determined. It was clearly shown that the short range order in compound Cu0.2Mg0.8O differs from a hypothetical alloy with MgO structure and from the copper oxide.
Subject(s)
Acidosis/etiology , Coronary Disease/complications , Acidosis/drug therapy , Acidosis/metabolism , Animals , Coronary Disease/drug therapy , Coronary Disease/etiology , Coronary Disease/metabolism , Cytoplasm/metabolism , Electrons , Energy Metabolism/drug effects , Homeostasis , Hydrogen-Ion Concentration , Hypoxia/drug therapy , Hypoxia/metabolism , Myocardium/metabolism , Oxidation-Reduction/drug effects , Oxygen Consumption/drug effects , Vitamins/metabolism , Vitamins/therapeutic useABSTRACT
Experiments on mice with simulated isobaric hypoxia and anoxia have demonstrated marked antihypoxic action of a complex of vitamins with electron-acceptor activity (ascorbic acid, riboflavine mononucleotide, lipoic acid, nicotinamide). In dog experiments, the complex of vitamins reduced metabolic acidosis in the ischemia zone as shown by the lactate release test and increased the collateral coronary circulation. The protective action of the drug recorded in hypoxia and regional myocardial ischemia is regarded as linked with the ability of the vitamin complex to raise the conjugation of oxidation and phosphorylation in the mitochondria of a pathologically altered myocardium, as well as with its membrane-stabilizing action and inhibition of lipid peroxidation.
