Does [TcF(CO)5] exist? The crystal and molecular structure of [Tc(CO)3(OH)0.49F0.51]4·[Tc(CO)5(BF4)].

Technetium pentacarbonyl fluoride [TcF(CO)5] was prepared for the first time by reaction of [TcI(CO)5] with solid AgF in a dichloromethane solution at -23 °C. Low temperature crystallization of the resulting compound in a glass vial yielded an unusual complex [Tc(CO)3(OH)0.49F0.51]4·[Tc(CO)5(BF4)] characterized by single crystal XRD.

Technetium(I) carbonyl dithiocarbamates and xanthates.

Technetium(I) tetracarbonyl complexes with diethyldithiocarbamate and methylxanthate ligands [TcL(CO)(4)] (L = S(2)CNEt(2) and S(2)COMe) were prepared. Conditions required for the formation of these complexes were found. The crystal and molecular structure of the xanthate complex was determined by single-crystal X-ray diffraction. [Tc(S(2)CNEt(2))(CO)(4)] undergoes decarbonylation both in solution and in the course of vacuum sublimation with the formation of a dimer [Tc(S(2)CNEt(2))(CO)(3)](2) whose structure was determined by single-crystal X-ray diffraction. In donor solvents, [Tc(S(2)CNEt(2))(CO)(4)] and [Tc(S(2)COMe)(CO)(4)] undergo decarbonylation with the formation of tricarbonyl solvates [TcL(CO)(3)(Sol)]. The crystal structure of the pyridine solvate [Tc(S(2)CNEt(2))(CO)(3)(py)], chosen as an example, was determined by single-crystal X-ray diffraction. The possibility of using bidentate S-donor acidic ligands for tethering the tetracarbonyltechnetium fragment to biomolecules was examined.

Hexacarbonyl-technetium(I) perchlorate.

The title compound, [Tc(CO)(6)]ClO(4), was synthesized by the reaction of [TcCl(CO)(5)] with AgClO(4), followed by acidification with HClO(4) under a CO atmosphere. The [Tc(CO)(6)](+) cation has close to idealized octa-hedral geometry, with the bond angles between cis-CO groups close to 90° and the Tc-C bond lengths in the range 2.025 (3)-2.029 (3)Å. The perchlorate anion is disordered over two crystallographically equivalent half-occupied positions. The Tc atom in the [Tc(CO)(6)](+) cation is located on an inversion centre.

Characteristics of the formation of systems activity in the brain and autonomic functions in children in conditions of the European North (discussion paper).

Results obtained from complex medical-physiological investigations performed during 10 scientific expeditions in the Arkhangel'sk Region in 2003-2005 are presented. The effects of climatological-geographic, biogeochemical, and social conditions of the conditions obtaining in the Far North region of Russia on sexual maturation, formation of the structural-functional organization of the brain, autonomic functions, and immunological and biochemical status of schoolchildren were studied using state-of-the-art neurophysiological methods (computerized electroencephalography, computerized rheoencephalography, computerized electric dipole origin tomography, etc.), psychophysiological and psychometric methods (assessment of the state of cognitive and memory functions, Wechsler intellectual scale), along with biochemical assay of monoamine oxidase (MAO, the key enzyme in adrenergic neurotransmitter metabolism) and the liver enzyme butyrylcholinesterase (BuChE) and physicochemical analysis of the levels of macroelements and trace elements in the body.

Age-related characteristics of brain development in children living in the north.

The morphofunctional age-related development of the brain was studied in schoolchildren living in the difficult climatological-geographic and socioeconomic conditions of the north (Arkhangel'sk region). Of the 62 students in country middle schools, EEG amplitude-frequency, time, and spatial measures corresponded to age norms (European norms) in only 10 cases (16%). A further 26 children (53%) showed minor abnormalities in the form of an inadequate degree of organization of the temporospatial EEG pattern, mainly in the frontal and temporal lobes of the brain, with increases in the levels of the theta and delta rhythms, and the absence of any marked "functional nucleus" in the alpha rhythm. In the remaining 14 children (29%), EEG measures showed more marked delays in mental development (DMD), which were combined with learning difficulties and abnormal behavior. The retardation in the morphofunctional development of the brain in northern children averaged 1.5-2 years, which coincides with delays in hormonal and physical development described by other authors.

[Characteristics of the brain system activity and vegetative function formation in children under conditions of the European north (a problem study)].

Results of complex medical-physiological research performed during 10 scientific expeditions in Arkhangelsk region in 2003-2005 are presented. Influence of climatic-geographic, biogeochemical and social conditions of North-West region of Russia on sexual maturation, formation of the brain structural-functional organization, vegetative functions, immunological and biochemical status of schoolchildren was studied with the aid of modern neurophysiologic (computer electroencephalography, computer rheoencephalography, computed electric dipole origin tomography, etc.), psychophysiological and psychometric methods (evaluation of cognitive and mnestic functions, Vechsler 1Q estimation), biochemical assessment of monoamine oxidase and butyrylcholinesterase activity, physical-chemical analysis of macro- and microelements in the organism.

[Special features of age development of the brain in children living in the north].

Special features of morphological functional age development of the brain in children living in difficult climatic-geographical and social-economical conditions of the North (Archangelsk region) were studied. It was found that among 62 examined pupils of middle country school only in 10 persons (16%) amplitude-frequency and temporal-spatial EEG parameters are in accordance with passport age (European standards). 38 pupils (61%) have insignificant deviations such as insufficient regularity of EEG spatial-temporal pattern in frontal and temporal parts of the brain, increased theta- and delta-rhythms, absence of distinct "functional nuclear" in alpha range. In remaining 14 pupils (23%) EEG parameters suggest a more expressed retardation of mental development coupled with problems in the learning and inadequate behavior. Retardation of terms of morphological functional development of the brain in children--northerners equals 1.5 - 2 years, which is in accordance with terms of hormonal and physical development' retardation, described by different authors.

[Electroencephalographic markers and the computerized evaluation of the severity of depression]. / Elektroéntsefalograficheskie markery i komp'iuternaia otsenka tiazhesti depressii.

In 24 patients with moderate, pronounced and extremely pronounced (according to Hamilton Scale) sings of depression EEG of frontal, temporal, parietal and occipital areas of brain hemispheres were investigated. Control group consisted of 24 normals, being under supervision for a year. 4 types of EEG patterns (matrices) probabilities of changes were selected; those parameters correlated with severity of depression and stage of depressive phase. A cyclic character of transformation of organization of bioelectric processes during the disease has been demonstrated: orders of matrices changes in cases with reduction and aggravation of depressive signs were opposite. Linear discriminant functions or EEG markers, significantly different for groups of patients with different severity of depression, have been obtained. It allowed to create the computer-based system of evaluation of depression severity with high diagnostic accuracy.

[The clinical picture and diagnosis of pancreatic carcinoma]. / K klinike i raspoznavaniiu kartsinomy podzheludochnoi zhelezy.

A total of 97 patients with pancreatic carcinoma were examined with sonography, computed tomography of the pancreas and endoscopy of the stomach and duodenum. The tumor involved mainly the head of the pancreas in 69 (71.1%), the body in 21 (21.7%) and the tail in 7 (7.2%) patients. Two basic types of the disease were identified: disseminated in 83 patients and rare in 14 patients. The disseminated type included a central (45 patients) and a peripheral (38 patients) variant. The latter is classed as peripheral (n = 30) and paraduodenal (n = 8). The rare types included masked variants (n = 6), miniblastomas (n = 3), megablastomas (n = 2) of the pancreas, as well as thrombotic variants of the disease (n = 3). The highest diagnostic value of sonography and computed tomography was observed in intrinsic peripheral variants of carcinoma. Gastroduodenal endoscopy along with biopsy of suspected segments is highly diagnostic in paraduodenal variants of the disease.

[Systemic organization of EEG in patients with different forms of schizophrenia]. / Sistemnaia organizatsiia EEG u bol'nykh s razlichnymi formami techeniia shizofrenii.

The EEG of the frontal, temporal, parietal and occipital areas of the brain were examined in patients with recurrent, shift-like, simple and paranoid schizophrenia as well as in healthy persons. Analysis of the EEG involved two stages, using computer. Making use of the distinguished discriminant functions--components (waves) of the EEG interrelated in a definite manner, which may be "EEG markers", it turned out possible to perform differential computer-aided diagnosis of healthy persons and patients with different schizophrenia patterns. In patients with the recurrent and paranoid patterns, the accuracy of coincidence of the clinical diagnosis with that established by means of computer appeared to be equal to 61%. In groups with shift-like and simple schizophrenia, the accuracy amounted to 35 and 33%, respectively.

[Use of a method of evaluating interrelations of EEG components for computer-assisted diagnosis of pathologic conditions of the brain in psychiatry]. / Primenenie metoda otsenki struktury vzaimodeistviia komponentov EEG dlia EVM-diagnostiki patologicheskikh sostoianii mozga v psikhiatrii.

The possibility of computer-assisted diagnose of schizophrenia, manic-depressive psychosis, psycho-organic++ syndrome according to the structure of EEG components interaction was studied in patients and healthy individuals. Differential diagnose was performed using discriminant analysis of the EEG pattern structure in single leads and in 8 simultaneous leads as well (16 and 128 variables, respectively). Local and spatially-organized discriminants were singled out that allowed to diagnose distinct nosologic forms. The technique allowed to perform computer diagnostic of psychoorganic syndrome with the 78% accuracy. This parameter was 75% for schizophrenia and 71% for manic-depressive psychosis. Healthy subject were diagnosed with 90% accurateness. Differential diagnosis among schizophrenia and other disorders proved most difficult.