[The prevention of suppurative-septic complications in severe burns by using immunotropic drug preparations in an experiment]. / Profilaktika gnoino-septicheskikh oslozhnenii pri tiazhelykh ozhogakh s pomoshch'iu immunotropnykh lekarstvennykh preparatov v éksperimente.

The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated. Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection. The study revealed that the injection of these immunomodulators in doses recommended by instructions for use did not affect the course of the infectious process, antibody production by immunocompetent cells and the death rate of experimental animals. The use of the course dose of any of these substances, introduced in a single injection, prevented the generalization of infection. The death rate of experimental animals dropped from 80.3% to 47.2%.

[Regulation of the water-electrolyte balance during neurosurgical operations with balanced anesthesia using sodium oxybutyrate]. / O reguliatsii vodno-élektrolitnogo obmena pri neirokhirurgicheskikh operatsiiakh v usloviiakh sbalansirovannoi anestezii oksibutiratom natriia.

Water-electrolyte homeostasis and its basic regulatory hormones have been studied in 36 patients with neurosurgical brain pathology during surgical interventions performed under balanced anesthesia (sodium hydroxybutyrate combined with NLA drugs). The study has revealed 3 types of reactions in hormones regulating water-electrolyte homeostasis: type I--a decrease in vasopressin (VP) concentration and renin-angiotensin-aldosterone system (RAAS) activity; type II--VP increase and RAAS activation; type III--an increase in VP content and RAAS disbalance. It has been shown that type I reaction is accompanied by marked osmotic disturbances. The impact of sodium hydroxybutyrate on RAAS is manifested in aldosterone secretion suppression.

[A matrix and method of preparing 2-fragment specimens for ultramicrotomy]. / Matritsa i sposob izgotovleniia dvukhfragmentnykh obraztsov dlia ul'tramikrotomii.

A matrix for the preparation of two-fragment specimens for ultramicroscopy of biologic objects is described. The matrix has the form of a monolithic plate 8-10 mm thick made of a material such as fluoroplast that does not copolymerize with the mounting medium. It contains 50-60 functional cells which are numbered. The upper part of a cell has a cylindrical shape (55 mm in diameter, 2-3 mm in height) while its lower part is shaped like a truncated cone (this part is 2-3 mm deep). A drop of mount and a piece of tissue are placed in the cell, after which a solid fragment of the test specimen is introduced into its cylindrical part till the fragment's end abuts against the wall of the conical part of the cell and comes in contact with the mount. The two are then caused to polymerize, and once the polymerization is completed, the ready specimens can be readily extracted by taking hold of the distal ends of the solid fragments that protrude over the surface of the matrix.

[Myocardial ultrastructure in fetal rabbits following mechanical trauma]. / Ul'trastruktura miokarda plodov krolikov posle ego mekhanicheskoi travmy.

An area of the myocardium of 23-day-old rabbit fetuses after mechanical tramua was studied electron-microscopically. Six days after trauma in the focus of lesion myocardial cells were found the general submicroscopic organization of which was identical to the ultrastructure of myocardium cells of intact animals and muscle cells of other parts of the left ventricle of the heart of experimental animals. Besides, in the former focus of lesion of the myocardium tissue electron microscopy revealed younger myocardial cells than those in the myocardium of the intact animals as well as cells showing early stages of differentiation. The results indicate that at the site of the lost myocardial tissue in 23-day-old rabbit fetuses 6 days after trauma there appears an intact cross-striated musculature of the heart.