[Modern state and prospects of perfection of medical agents of indication of poisoning and high-toxic substances].

One of actions of medical protection of staff is carrying out of indication of poisoning and high-toxic substances. It is shown, that indication toxic substances is carried out with use of means of the continuous and periodic control: display elements, automatic gas alarms and gas detector, the army device of chemical investigation, the device of chemical investigation of medical and veterinary services, the medical device of chemical investigation, medical field chemical laboratory, etc. Opportunities of the devices intended for equipment of divisions and establishments of medical service Armed Forces of the Russian Federation with the purpose of carrying out of indication of chemical substances are analysed. Offers on perfection of the organization and carrying out of indication of chemical substances in medical divisions and establishments Armed Forces of the Russian Federation are formulated, prospects of their equipment are proved by modem indicator devices and the equipment.

[Retrospective dose estimation in remote period after exposure using different biological methods]. / Retrospektivnaia otsenka doz v otdalennyi postraditsionnyi period raznymi biologicheskimi metodami.

Investigation of application of chromosome aberrations of lymphocytes in peripheral blood for biological dosimetry purposes in remote (up to 40 years) period after acute exposure to doses of 1 Gy and more was carried out. The comparative analysis of frequency of unstable and stable (using FISH and G-banding methods) aberrations was performed for 24 subjects accidentally exposed to radiation on nuclear submarines during 1961-1985. Statistically significant increasing of frequency of dicentrics and centric rings was determined in the exposed subjects in remote period after exposure to compare with controls. Their sum frequency in the exposed group varied depending on ARS heaviness from 0.1 to 1.0 aberrations per 100 cells. In control group it was from 0 to 0.2 correspondingly. Translocation frequency (complete + incomplete) fixed by FISH method (2, 4, and 12 chromosomes) varied within the limits of 0.2-16.0 for exposed subjects and 0.3-1.26 translocations per genome per 100 cells for controls. Some examined persons (5 subjects) exposed to accident in 1985 had results of analysis of unstable chromosome aberration in acute period after exposure that allow to estimate obtained doses by dicentrics frequency which having good correlation with ARS heaviness. Individual dosed using traslocation frequency were defined retrospectively in 11 from 21 exposed persons. They correlate with calculated physics doses and doses estimated by haematolotical parameters in acute period and also doses obtained by ESR spectroscopy of tooth enamel in remote period.