Influence of rare earth metals on volumetric characteristics of Al-Ni-Co-R alloys in crystalline and liquid states.

Density of Al-Ni-Co-R (R = Nd, Sm, Gd, Tb, Yb) glass-forming alloys is studied experimentally by gamma-absorption method in a wide temperature range including crystalline and liquid states. Molar volumes and thermal expansion coefficients are calculated from the experimental data. It is shown that these melts remain strongly microheterogeneous systems at small overheatings above liquidus. Some regimes of melt heat treatment before quenching are discussed.

[THE ISSUE OF THE IMPACT OF RADIOACTIVE SUBSTANCES ON PUBLIC HEALTH AND COUNTERMEASURES FOR RADIATION EXPOSURE AS A GLOBAL PROBLEM].

The widespread use in today's world of radioactive sources d in energy, medicine, engineering and construction, for contaminant tracking and food sterilization increases the likelihood of accidental exposure. The use of ionizing radiation and radioactive elements can directly or indirectly cause life-threatening complications, such as oncopathology, radiation burns, and impaired immunity. Pollution of the environment with radioactive elements and depletion of the ozone layer also contribute to an increase in the level of radiation exposure. To protect the health of the population living in contaminated areas and consuming locally produced products, it is necessary to organize a system for monitoring radioactive damage, as well as special anti-radiation protective measures in the field of agriculture and forestry, hunting and fishing, and providing the population with food. The purpose of the study is to analyze modern scientific data on the effect of ionizing radiation on reproductive function and modern approaches aimed at correcting its violations. Bibliographic, information-analytical methods and methods of comparative analysis were used.

The hyperfine magnetic fields and the effect of high pressure on the magnetic transition temperatures of the noncentrosymmetric FeRhGe2compound (B20).

Hyperfine parameters and the pressure dependence of the magnetic transition temperatures of FeRhGe2have been investigated. Sample has been prepared using high pressure-high temperature synthesis technique. FeRhGe2consists of two B20 structure phases with close lattice constants. The phase separation stays constant in the temperature range 4-300 K. The magnetic transition temperaturesTc1= 213 K andTc2= 135 K of FeRhGe2slightly increases with pressure in the range 0-4.5 GPa. We have compared this pressure dependence with some others compounds in the family Fe1-xRhxGe. The two phases in FeRhGe2have slightly different values of the hyperfine magnetic fields.

[An integrated approach for early recovery of function in patients after fractures of the humerus in its proximal section]. / Kompleksnyi podkhod dlya rannego vosstanovleniya funktsii konechnosti u patsientov posle perelomov plechevoi kosti v ee proksimal'nom otdele.

The frequency of fractures of the proximal humerus (PH) is 4-5% of fractures of all human bones and can reach 80% of all bone injuries of the humerus. An analysis of the long-term results of the methods used to treat fractures of the proximal humerus showed the absence of a generally accepted universal method that provides consistently good results for all variants of fractures of the PH. PURPOSE OF THE STUDY: Creation of a complex highly effective system for the treatment of PH fractures, which includes a minimally invasive method of surgical treatment using the method of cephalomedullary osteosynthesis with direct locking pins and a highly specialized program of rehabilitation measures using a biofeedback (BFB) device, which will reduce the duration of treatment and improve the results of functional recovery injured limb. MATERIAL AND METHODS: The results of treatment of 214 patients with fractures of the proximal humerus were analyzed. Of these, in 122 (57%) patients (the main group) osteosynthesis was used with a direct cephalomedullary fixator with the possibility of blocking the screws in the nail in different planes. The comparison group included 92 (43.0%) patients treated using other surgical techniques. Rehabilitation measures were started in the early postoperative period (from the 2nd day) in both groups and included a complex of physiotherapeutic treatment, physical exercises in different modes, in addition in the main group of the study, training was performed using a device with biofeedback. RESULTS: It is shown that the used treatment approach allows to increase the frequency of achieving good and excellent (52.4% in the main group and 27.2% in the comparison group) results and reduce the frequency of unsatisfactory results of treatment (9.8% in the main group and 21.7% in the comparison group) on the Constant score. CONCLUSION: The data obtained prove the high efficiency of the developed complex method for the treatment of proximal humerus fractures and restoration of the function of the upper limb.

[Primary retrograde distal access for endovascular interventions in patients with lower limb ischemia]. / Pervichnyi retrogradnyi distal'nyi dostup pri endovaskulyarnykh vmeshatel'stvakh u patsientov s ishemiei nizhnikh konechnostei.

OBJECTIVE: To evaluate safety and technical efficiency of primary retrograde distal access for endovascular interventions in patients with lower limb ischemia. MATERIAL AND METHODS: A prospective analysis included 25 endovascular procedures via primary retrograde distal access in 23 patients with chronic obliterating diseases of lower limb arteries. Occlusive lesion of femoral-popliteal segment was observed in 68% of cases, occlusion of at least one tibial artery was also found in 68% of cases. In 44% of cases, occlusive lesion was localized at several levels. Percutaneous intervention via anterior tibial artery or dorsalis pedis artery was performed in 68% of cases, posterior tibial artery - 24% of cases, peroneal artery - 8% of cases. We used 2 accesses in 92% of cases (the main one for intervention and additional one for angiography). In 8% of cases, intervention was carried out through a single access. Angiosome artery was punctured in 65% of cases. The only patent tibial vessel was used in 20% of cases. In 24% of cases, we performed antegrade recanalization of 'adjacent' tibial artery via distal access. RESULTS: Primary retrograde distal access was successfully performed in 100% of cases. Retrograde revascularization was not successful in all cases (successful recanalization rate 96%, retrograde intervention rate - 92%). Femoral access was performed in 8% of cases. Antegrade blood flow through at least one tibial artery was restored in all cases. Direct revascularization of the affected angiosome was performed in 15 patients with foot necrosis, indirect revascularization through collaterals - in 5 patients. Local complications of surgical access occurred in 12% of cases. CONCLUSION: Endovascular revascularization via primary retrograde distal access was technically effective in most cases. There were no complications with systemic consequences.

[The role of supplying population with vitamin D in conditions of COVID-19 pandemic: foreign publications review].

The overview of scientific information concerning actual characteristics of population's supply with vitamin D and its role in case of risk of development of infectious diseases and COVID-19 is presented. The analysis established that vitamin D deficiency contributes both to higher risk of susceptibility to infectious agent and to negative impact to course and outcome of disease. The significant role of vitamin D in prevention and treatment of viral diseases is established. The international research studies confirm that at infectious diseases and early stages of COVID-19 protective immune response is responsible for elimination of the virus. Therefore, using vitamin D in treatment of COVID-19 is the strategy of immune protection. The authors consider that in case of infectious risks, preventive application of vitamin D is necessary. In case of initial manifestations of COVID-19, it is appropriate to promptly achieve levels of optimal status of micro-nutrient supply.

[The modern technologies of vitaminization in diseases prevention: publications review].

The article presents review of publications and official documents of international state, departmental and public organizations related to implementation of targeted programs of enrichment of vitamins and minerals with food rations and food products, including application of up-to-date technologies. The data is presented about practical implementation of developments in the field of problems of modern molecular nutrition, nutrigenomics, investigating effect of human nutrition on gene expression, and as well as on bioinformation approaches of nutrigenomics, intestinal microbiota metagenome, gene regulation or gene expression in a microbiome.

GROWTH AND CHARACTERIZATION OF A TISSUE-ENGINEERED CONSTRUCT FROM HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS.

OBJECTIVE: To optimize a bioengineered «I-Wire¼ platform to grow tissue-engineered constructs (TCs) derived from coronary artery smooth muscle cells and characterize the mechano-elastic properties of the grown TCs. MATERIALS AND METHODS: A fibrinogen-based cell mixture was pipetted in a casting mold having two parallel titanium anchoring wires inserted in the grooves on opposite ends of the mold to support the TC. The casting mold was 3 mm in depth, 2 mm in width and 12 mm in length. To measure TC deformation, a flexible probe with a diameter of 365 mk and a length of 42 mm was utilized. The deflection of the probe tip at various tensile forces applied to the TC was recorded using an inverted microscope optical recording system. The elasticity modulus was calculated based on a stretch-stress diagram reconstructed for each TC. The mechano-elastic properties of control TCs and TCs under the influence of isoproterenol (Iso), acetylcholine (ACh), blebbistatin (Bb) and cytochalasin D (Cyto-D) were evaluated. Immunohistochemical staining of smooth muscle α-actin, desmin and the cell nucleus was implemented for the structural characterization of the TCs. RESULTS: The TCs formed on day 5-6 of incubation. Subsequent measurements during the following 7 days did not reveal significant changes in elasticity. Values of the elastic modulus were 7.4 ± 1.5 kPa at the first day, 7.9 ± 1.4 kPa on the third day, and 7.8 ± 1.9 kPa on the seventh day of culturing after TC formation. Changes in the mechano-elastic properties of the TCs in response to the subsequent application of Bb and Cyto-D had a two-phase pattern, indicating a possible separation of active and passive elements of the TC elasticity. The application of 1 µM of Iso led to an increase in the value of the elastic modulus from 7.9 ± 1.5 kPa to 10.2 ± 2.1 kPa (p<0.05, n = 6). ACh did not cause a significant change in elasticity. CONCLUSION: The system allows quantification of the mechano-elastic properties of TCs in response to pharmacological stimuli and can be useful to model pathological changes in vascular smooth muscle cells.

[Treatment of chronic blepharitis]. / Lechenie khronicheskikh blefaritov.

The most effective method of treating chronic blepharitis - a disease with multifactorial pathogenesis requiring an individual approach - is a combination of remedial measures that addresses eyelids hygiene and includes medicated and device therapy.

[The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy]. / Sostoianie mikrotsirkuliatsii i trombotsitarnogo zvena gemostaza u patsientov s ishemicheskim insul'tom posle provedeniia sistemnoi tromboliticheskoi terapii.

AIM: The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy. MATERIAL AND METHODS: Forty-two patients after systemic thrombolytic therapy (TLT) (mean age 64.26 [60.58; 68.06]) and 47 patients without TLT (54.52 [47.48; 60.83]) were studied. The study of platelet hemostasis was conducted with the determination of platelet aggregation (AT) on adrenaline, ADP, ristomycin, spontaneous aggregation on days 1, 7 and 14. Studies of the state of microcirculation of cerebral vessels were carried out using the laser Doppler flowmetry (LDF). RESULTS AND CONCLUSION: Characteristics of changes in induced AT and parameters of the microcirculation system in patients after systemic TLT at 1, 7 and 14 days in comparison with the indices of patients without TLT were revealed that allowed to expand the understanding of pathological mechanisms of the microcirculatory bed, their connection with violations of central hemodynamics and to obtain additional markers of disease course and prognosis.

[Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry]. / Issledovanie mikrotsirkuliatsii krovotoka i limfotoka v kozhe vek metodom lazernoi dopplerovskoi floumetrii.

AIM: to study normal blood and lymph microcirculation of the upper and lower eyelids in different age groups. MATERIAL AND METHODS: The study included 108 volunteers (216 eyes) aged from 20 to 80 years with no signs of changes in anterior segment structures, who were grouped by age ranges (20-30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years, and 71-80 years) into 6 groups equal in gender and quantitative composition. In all volunteers, microcirculation of the upper and lower eyelids was examined by laser Doppler flowmetry (LDF) ('LASMA MC-1' peripheral blood and lymph flow analyzer and 'LASMA MC' laser diagnostic complex, LASMA LLC). The average perfusion changes in blood and lymph flow as well as blood and lymph flow oscillations were analyzed. RESULTS: Blood and lymph flow in the microvasculature of the upper and lower eyelids is variable and depends on neither the age, nor gender of the test subject. On LDF-gram, every increase in amplitude of blood flow corresponds to a decrease in that of lymph flow. CONCLUSION: The non-invasive method of LDF expands our diagnostic capabilities as it enables assessment of not only blood, but also lymph flow. The data obtained can serve as a starting point for exploring microcirculation in different age groups in the presence of different pathological processes.

Thermal expansion of monogermanides of 3d-metals.

Temperature dependent powder and single-crystal synchrotron diffraction, specific heat, magnetic susceptibility and small-angle neutron scattering experiments have revealed an anomalous response of MnGe. The anomaly becomes smeared out with decreasing Mn content in Mn1-x Co x Ge and Mn1-x Fe x Ge solid solutions. Mn spin state instability is discussed as a possible candidate for the observed effects.

[Characteristics of microcirculation in patients with acute ischemic stroke and chronic cerebral ischemia]. / Osobennosti sostoianiia mikrotsirkuliatsii u patsientov s ostrym ishemicheskim insul'tom i khronicheskoi ishemiei golovnogo mozga.

OBJECTIVE: To study microcirculation in patients with acute ischemic stroke (IS) using the method of laser Doppler fluorimetry (LDF). MATERIAL AND METHODS: We examined 19 patients with acute carotid IS, including 12 patients who received thrombolytic therapy. The reference group included 22 patients with chronic cerebral ischemia without a history of IS. Computed and magnetic resonance tomography of the brain, ultrasound diagnosis of head and neck vessels, the study of the changes in neurological status, emotional sphere, cognitive functions and laboratory methods were used. RESULTS: An index of total blood flow in the microcirculatory bed on the side of stroke was lower compared to that in patients with chronic cerebral ischemia. The study of parameters of microcirculatory bed regulation revealed an increase of blood inflow into the microcirculatory bed with the augmentation of the myogenic activity of arterioles and primarily the nutritional regimen of microhemocirculation. A decrease in the myogenic activity in the microcirculation system and nutritional direction of microhemodynamics were noted in patients with large IS. In some cases, non-nutritional regimen and/or venule congestion were observed. CONCLUSION: The study of the microcirculation system with the LDF method can be used as the method of early diagnosis of unfavorable variants of cerebral microcirculation that is necessary for outcome prognosis and its correction.

[Functional Status of Microcirculatory-Tissue Systems during the Cold Pressor Test].

Using non-invasive optical methods of laser Doppler flowmetry, tissue reflectance oximetry and pulse oximetry, we investigated the dynamics of parameter changes of microcirculatory-tissue systems (MTS) when using cold pressor test (CPT) on 32 conventionally healthy volunteers. According to differences in the recovery rate of oxygen consumption during CPT, volunteers can be conditionally divided into 2 groups: 1--displaying normal physiology and 2--with a tendency to angiospasm and lack of functional recovery of the MTS. To identify possible causes of angiospasm, we performed a detailed analysis of blood flow oscillations. This analysis revealed that the cause of angiospasm may be a violation of the tone-shaping myogenic mechanisms regulating resistive microvessels, disturbances to the microcirculation of stagnant blood, or a combination of both of these factors. Use of the CPT for functional assessment of MTS allows us not only to estimate the reserve capabilities of the MTS, but also to identify--at a pre-clinical stage-propensity to angiospasm, which has practical value in the clinic.

[Equipment of field units of the medical service of the Armed Forces with modern medical complexes on the basis of pneumo-frame modules, and procedure of the use].

Equipment of field units or ine meaical service of the Armed Forces with modem medical complexes on the basis of pneumo-frame modules, and procedure of the use. On the basis of experience of medical supply in local wars and modern armed conflicts, when liquidating medical and sanitary disaster consequences the authors revealed the main organizational problems in army echelon of the medical service. It is shown that these problems can be solved by means of deployment of medical units and subunits. Requirements for means of deployment are defined. Present organic equipment is assessed. The authors showed advantages ofpneumo- framed modules, their tactic and technical characteristics, variants of the use when deploying army levels of field medical evacuation.

[The state research and test institute of military medicine of the Ministry of Defence of the Russian Federation celebrates the 85th anniversary].

The state research and test institute of military medicine of the Ministry of Defence of the Russian Federation celebrates the 85th anniversary. The article is devoted to the anniversary of the newly reconstituted state research and test institute of Military Medicine of the Ministry of Defence of the Russian Federation. The institute was closed down in 2011 and worked exclusively as a structural subdivision of the Kirov Military Medical Academy for tests of ergonomic characteristics of a weapon and military equipment. Recreation of the institute allowed to engage highly qualified personnel and change the range of tasks, identified prospects of fundamental and applied researches in the field of development of hemostatic agents and anaesthetics, physiology of military work, medical robotics, development of technical means for medical services, and development of new medical technologies. The authors formulated prospects of development of the institution and its participation in the implementation of the primary tasks of the Medical Service to preserve and improve the health of military personnel.

[Rehabilitation of the patients with osteoarthritis].

Under the term "osteoarthritis" (OA) is currently meant a clinical syndrome resulting from the combined effect of articular pain and disordered functional activity leading to the deterioration of the quality of life of the patients. The principal objective of rehabilitation of the patients presenting with GA in which all patients with this condition are in need practically after each next aggravation of the pathological process is to relive pain syndrome and restore the functional ability of the joints lost or deteriorated after each exacerbation in order to eventually improve the quality of life of the patients experiencing the constantly progressing degenerative process in the musculoskeletal system. The effectiveness of pain alleviation, the degree of improvement'of the joint functional activity and the general condition of the patient are considered as the criteria for the assessment of the effectiveness of the rehabilitative treatment. These criteria have been chosen in accordance with the recommendations of the OMERACT international working group (outcome measures in rheumatology). In addition, the quality of life associated with the health status and the adverse effects of the rehabilitative measures were estimated. Bearing in mind comorbidity in the patients presenting with OA, one of the main challenges is the development of the scientifically sound rationale for the application of non-pharmacological technologies of physical therapy, remedial gymnastics and massage for the prevention and elimination of an aggravation of the secondary aseptic inflammatory process associated with OA and the subsequent rehabilitative treatment for the restoration of the lost locomotory stereotype and the quality of life of the patients. One of the effective methods of physical therapy used for the treatment and rehabilitation of the patients presenting with GA is hyperbaric gaseous cryotherapy. This method makes use of the heat rejection phenomenon to which the organism responds, either in the compensatory or/and reflectory mode, by the activation of the heat production processes in the tissues due to the stimulation of the metabolic processes as well as the vascular, neuroendocrine, and immune systems involved in the regulation of homeostasis which produces the desired therapeutic effect apparent as the cessation of secondary aseptic inflammation and progressive degeneration process associated with OA. Taking into consideration the aforesaid, the objective of the present study was the scientifically sound substantiation of the application of hyperbaric gaseous cryotherapy as a constituent of the combined rehabilitative treatment of the patients presenting with gonarthritis and a coxarthrosis. This article was designed to report the results of such combined treatment obtained in 110 patients (22 men and 88 women) with gonarthritis and a coxarthrosis of the II-III stages (based on the classification of Kellgren). The patients aged from 40 to 75 years which were randomly divided into two groups (the main and the control (comparison) groups) comprising 55 patients each. The patients of the main group, unlike those in the control one, were treated with the use of hyperbaric gaseous cryotherapy in addition to traditional physical therapy and balneotherapy, therapeutic physical exercises, and massage. The results of the treatment were evaluated making use of the Lequesne, WOMAC, Likert international indices. It allowed to identify the predictors for the use of hyperbaric gaseous cryotherapy and to increase the effectiveness of the rehabilitative treatment of the patients suffering from OA of the large joints by 33% in comparison with the control group. The highest clinical effectiveness of 90% was achieved in the cases of at a.gonarthritis; it was somewhat lower (64%) in the cases of coxarthritis.

[Metabolic memory enhances hormesis effect to the copper ions in age-depended manner].

The ability of young and old rats to manifest the hormesis effect to lethal doses of copper sulphate and the ability to save the induced "adaptive" pattern of redistribution of copper ions after the transfer of animals in the standard conditions is the mechanism of metabolic memory. It was found that pretreatment of animals with low-dose (1 mg per 100 g body mass, i.e. 33% of the lethal dose) of copper sulfate induced the formation of their resistance to lethal doses (3 mg per 100 g), so the hormesis effect was manifested. Hormesis effect depended on the number of pre injections of small doses of copper sulphate in an S-shaped manner. The protective effect increased after 1 to 3 of preliminary injections of copper sulfate, and after four or more injections the hormesis effect decreased. It is shown that the cardinal role in intracellular pattern of copper ion redistribution play heat-stable copper binding proteins 12 kDa cytosolic proteins. The formed "adaptive" pattern of intracellular distribution of the copper ions may be reproduced, after at least, one month. The prolonged hormesis effect can be attributed to the forming metabolic memory. The intracellular distribution pattern of the copper ions was age-dependent. Age-related differences were found in hormesis effect induced by copper ions, which results in increased binding capacity of copper binding proteins in old animals, with a higher content of copper ions in the mitochondria and microsomes as compared to young animals.

[Modern capabilities of laparoscopic surgery for kidney cancer treatment].

Retroperitoneal surgical approach is the main component of operative intervention. This approach predetermines quality of surgical operation and the risk of intraoperative complications, an opportunity of their prevention. Lymphadenectomy is the unique method allowing authentically to confirm cancer in the lymph nodes and to evaluate a stage of disease. Endoscopicsurgical nephrectomy is the operation that keeps advantages of minimally invasive surgical approach in the majority of kidneys diseases without loss of quality of surgical treatment.

Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms.

Multi-functional laser non-invasive diagnostic systems allow the study of a number of microcirculatory parameters, including index of blood microcirculation (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). This research aimed to use such a system to investigate the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted on eight healthy volunteers of 21-49 years. These volunteers were observed between one and six months, totalling 422 basic tests (3 min each). Measurements were performed on the palmar surface of the right middle finger and the lower forearm's medial surface. Rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Combined tissue oxygen consumption data for all volunteers during 'adaptive changes' increased relative to normal conditions with and without arteriovenous anastomoses. Data analysis revealed resonance and synchronized rhythms in microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and possibly psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes may lead to increased oxygen consumption as a result of increased microvascular blood flow velocity.