ABSTRACT
Complex regional pain syndrome (CRPS) and postherpetic neuralgia (PHN) represent neuropathic pain syndromes that may appear with similar clinical signs and symptoms. Medical history and clinical distribution of symptoms and signs (PHN typically at the thorax; CRPS typically at the limbs) is obvious in most cases, helping to discriminate between both disorders. Here, we present a patient suffering from CRPS II following PHN of one upper extremity. This case demonstrates that both etiology and part of the body affected by a neuropathy influence the pain phenotype.
Subject(s)
Causalgia/diagnosis , Causalgia/etiology , Edema/etiology , Herpes Zoster/complications , Herpes Zoster/diagnosis , Neuralgia, Postherpetic/complications , Neuralgia, Postherpetic/diagnosis , Acute Disease , Aged , Arm , Diagnosis, Differential , Edema/diagnosis , Female , Humans , Movement DisordersABSTRACT
It is the goal of palliative care to provide as large a relief of the disease symptoms as possible for patients, who are incurably sick, in order to improve the quality of the remaining life. Some of the symptoms can hardly be treated; others like pain, dyspnea, gastrointestinal complaints or sweating can usually be well alleviated. The condition for this is a careful evaluation of the clinical status before the treatment, in order to reach symptom relief by purposeful actions without new side effects.
Subject(s)
Chronic Disease/therapy , Pain/prevention & control , Palliative Care/methods , Quality of Life , Terminal Care/methods , Germany , Humans , Practice Guidelines as Topic , Practice Patterns, Physicians'ABSTRACT
OBJECTIVES: Complex regional pain syndromes (CRPS) can be relieved by sympathetic blockade. Different sympathetic efferent output channels innervate distinct effector organs (ie, cutaneous vasoconstrictor, muscle vasoconstrictor. and sudomotor neurons, as well as neurons innervating deep somatic tissues like bone, joints, and tendons). The aim of the present study was to elucidate in CRPS patients the sympathetically maintained pain (SMP) component that exclusively depends on cutaneous sympathetic activity compared with the SMP depending on the sympathetic innervation of deep somatic tissues. METHODS: The sympathetic outflow to the painful skin was modulated selectively in awake humans. High and low cutaneous vasoconstrictor activity was produced in 12 CRPS type 1 patients by whole-body cooling and warming (thermal suit). Spontaneous pain was quantified during high and low cutaneous vasoconstrictor activity. By comparing the cutaneous SMP component with the change in pain that was achieved by modulation of the entire sympathetic outflow (sympathetic ganglion block), the SMP component originating in deep somatic structures was estimated. RESULTS: The relief of spontaneous pain after sympathetic blockade was more pronounced than changes in spontaneous pain that could be induced by selective sympathetic cutaneous modulation. The entire SMP component (cutaneous and deep) changes considerably over time. It is most prominent in the acute stages of CRPS. CONCLUSIONS: Sympathetic afferent coupling takes place in the skin and in the deep somatic tissues, but especially in the acute stages of CRPS, the pain component that is influenced by the sympathetic innervation of deep somatic structures is more important than the cutaneous activation. The entire sympathetic maintained pain component is not constant in the course of the disease but decreases over time.
