ABSTRACT
We report two patients who presented with increasing malaise and myalgia, and had biopsy-proven polymyositis. Their conditions deteriorated after corticosteroid treatment, and repeat muscle biopsies showed adult and larval nematodes. Anthelminthic treatment was completely successful in both cases. The infecting nematode appears to belong to a new genus and is, to our knowledge, the first known muspiceoid nematode to infect humans. Its life cycle and the route of infection are unknown.
Subject(s)
Nematode Infections/parasitology , Polymyositis/parasitology , Adult , Animals , Biopsy , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Male , Microscopy, Electron , Middle Aged , Muscle, Skeletal/parasitology , Muscle, Skeletal/pathology , Nematoda/classification , Nematoda/ultrastructure , Nematode Infections/pathology , Polymyositis/pathology , Trichinella/classification , Trichinella/ultrastructure , Trichinellosis/parasitology , Trichinellosis/pathologyABSTRACT
Pseudohypoparathyroidism is an uncommon cause of movement disorders. We describe the case of an otherwise well 11-year-old girl, who presented with dystonia and was subsequently shown to have the classical metabolic abnormalities of pseudohypoparathyroidism. Cranial computerised tomographic scanning (CT scanning) showed intracerebral calcification of the basal ganglia and frontal lobes.
