ABSTRACT
Las infecciones respiratorias, uno de los síndromes más frecuentes a nivel comunitario pueden ser de dos tipos: infecciones del tracto respiratorio superior o inferior. En su gran mayoría son inicadas por una infección viral transformando el terreno vulnerable a la sobre infección bacteriana. Hasta 2/3 de los pacientes son tratados desde el inicio de los síntomas con antibióticos, aunque este tratamiento no influye positivamente sobre el curso de la enfermedad. Renikan, fitofármaco extraído de la raíz del Pelargonium Sidoides, posee un triple mecanismo de acción: antiviral, antibacteriano y mucolítico, antiviral, porque activa los mecanismos de defensa antivirales orgánicos, antibacetriano, por su actividad bacteriostática directa e indirecta, y mucolítico, por sus propiedades secretomotoras y expectorantes. El objetivo fue comprobar la efectividad y tolerabilidad de Renikan en el tratamiento de las infecciones respiratorias. Diseño abierto y multicéntrico. Se seleccionaron niños de 6 a12 años y adultos de cualquier sexo o raza, con infecciones del tracto respiratorio superior. A los cuales se le suministró Renikan durante 7 días continuos, se evaluó: evolución de los síntomas, necesidad de uso de antibióticos y la escala de resultados integraticos IMOs. Ingreason un total 305 pacientes, 156 adultos y 149 niños distribuidos en tres grupos de estudio: Rinosinusitis, 97 pacientes, los cuales presentaron mejoría de sus síntomas en un 86% en los adultos y no utilizaron antibióticos en un 86%; los niños mejoraron en un 80%, y no usaron antibióticos en 91%. En el caso de las Amigdalitis hubo 108 pacientes con una mejoría sintomatológica en adultos del 92% y en los niños el 89%, no antibióticoterapia en el 86% de los adultos y 93% de los niños. El uso de Renikan en pacientes con infecciones del tracto respiratorio superior, demuestra ser seguro y efecivo tanto en adultos como en niños mayores de 6 años
Respiratory tract infections are the most common syndromes at community, there are two types: upper and lower respiratory tract infections. The vast majoritary are stared by a viral infection transforming the land vulnerable into a bacterial infection. The 2/3 o patients is treated from the onset of symptoms with antibiotics, although it is known that this treatment not positively influences the course of the disease. Renikan, herbal extrated fron the root of pelargonium sidoides has a threefold mechanism of action: antibiotic and mucolytic, antiviral, because it activates the natural antiviral mechanism of defense; antibacterial, due to its direct and indirect bacterostatic action and mucolytic, owing to its secretomotory and expectorant properties. To test the effectiveness and tolerability of renikan in the treatment of respiratory infections. Open desing, multicenter study. We selected children 6-12 years'age and adults of any sex orrance with upper respiratory tract infecctions. Theyreceived renikan for 7 consecutive days, changes in symptoms; necessity of antibiotic use and the integrative medicine outcome scale (IMOS) were evaluated. Of total of 305 patients, 156 adults and 149 children were divided into three groups: 97 rhinosinusitis patients, who showed symptoms improvement in 86% of adults and 91% of children, in 108 tonsillitis patients, an improvement of symptoms was found in 92% of adults and 89% of children, no antibiotic use were in 86% of adults and 93% of children, and, in a third group consistng of 100 patients with bronchitis, improvement was report in 98% od adults and in 73% of children, no antibiotics were used in 88% of adults and 96% of children. The use of concomitant therapy decreasedin 50% of cases and only 0.02% of patients had adverse events. The use of renikan use in patients with upper respiratory tract infections was shown to be safe and effective in both adults and children over 6 years of age
Subject(s)
Child , Bronchitis/complications , Respiratory Tract Infections/complications , Respiratory Tract Infections/diagnosis , Pelargonium reniforme , Anti-Bacterial Agents , PharmacologyABSTRACT
The variables were analyzed longitudinal anthropometric that measures the dimension and corporal composition of students of the first Stage of Basic Education of the Educative of the Grand Colombia Educational Unit. The analyzed variables they were: Age, Sex, Weight (W), Height (H), Circumference (AC), Index of Corporal Mass (CMI), cutaneous fold: Triceps (TrP) and Subescapular (SeP), Muscular Area (AM) and fatty Area (FA). 141 children were evaluated with age of beginning to the 6 and 8 years with pursuit of four annual measurements. It was applied a sampling stratified random with equal afijación. The scholars were measured following the techniques established and accepted internationally he stops such aim. One settled down as point of cut between percentiles 10 and 90. Used values of reference were those of the Cross-sectional Study of Caracas (ETC) and of the Longitudinal Study of Caracas (CSCMA). In the analysis longitudinal it was applied to the method "Tracking" and the statistical Kappa in order to determine the channel of growth in each boy and the speed was evaluated of growth of the students. In the four evaluated groups, W and the H have biggest trackng indices with respect to the others variables. The tracking index was constant (Kappa = 0.25) for all the variables and all the groups, opposite situation to the global Kappa, as it was located in the category of "G ood" (Kappa = 0.40 to 0.75) for the W and H in all the groups of evaluated scholars. The AC in the girls of both series of ages and in CMI, only in the girls with follow-up at 6 years canalization is observed "Good". One stayed in "Low" (Kappa = < 0,40) in all the sample of students the TrP, SeP, MA and FA. Variables of corporal dimension register good canalization, unlike the variables that measure corporal composition, which are located in loss canalization. The girls of both groups register greater speed of growth in Weight that the boys. The values of the average in the W and H, in evaluated students, end speed (S3) he is superior to initial speed (S1), therefore, the speed of growth it increases with the age. The maximum speed of growth is registered in the S3. In the evaluated students the variables that better they canalize are those of corporal dimension, is inferred, that corresponds to a growth pattern hoped.
Subject(s)
Body Composition , Body Size , Body Height , Body Mass Index , Body Weight , Child , Child Development , Female , Humans , Male , Prospective Studies , Reference Values , Sex Factors , Skinfold Thickness , Venezuela/epidemiologyABSTRACT
Se explora la evaluación del hipocinetismo como factor de riesgo para la salud. A tal fin fueron analizados los hábitos de actividad física y el nivel de riesgo cardiovascular, en 314 estudiantes no atletas de la Universidad Central de Venezuela con edades entre 17 y 29 a¤os, mediante la aplicación del Cuestionario Internacional de Actividad Física-IPAQ (2004) y un cuestionario de Hoeger y Hoeger (2002) para la estimación del riesgo cardiovascular. Los resultados indicaron que globalmente 31,53 por ciento de los sujetos tenían un nivel de actividad física que se relaciona con hipocinetismo. Se evidenció que las jóvenes estudiadas mostraron mayores niveles de riesgo cardiovascular. Se identificaron asociaciones entre las variables género y la categoría de riesgo cardiovascular, asícomo entre esta última y los niveles de actividad física, apuntando a que el hipocinetismo representa un factor de riesgo adicional en el desarrollo de enfermedades crónicas no transmisibles en los ucevistas evaluados.
Subject(s)
Humans , Male , Female , Physical Endurance , Physical Exertion , Students , Medicine , VenezuelaABSTRACT
In the Caracas Longitudinal Study, the canalization of 24 girls that started follow-up at age 4, 43 at age 8, and 32 at age 12 in: height (H), weight (W), Body Mass Index (BMI), cholesterol (CHOL), triglycerides (TG) and glucose (GL), was studied using Schneiderman n Tracking Index (TI) and age to age correlations. TI presented a gradient H > W > BMI > CHOL and lower in TG and GL. TI of all variables diminished increased with age and in BMI and CHOL. Age to age correlations were significant at all ages in H, W. and BMI and higher in CHOL (p < 0.01) compared to TG and GL. The significant tracking of H, W, BMI and lipids, specially CHOL, is relevant in prevention of non-communicable chronic diseases.
Subject(s)
Blood Glucose/analysis , Body Height , Body Mass Index , Body Weight , Lipids/blood , Age Factors , Child , Child, Preschool , Chronic Disease , Female , Follow-Up Studies , Humans , Longitudinal Studies , Risk Factors , Social Class , Time Factors , VenezuelaABSTRACT
To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the factor V Leiden mutation. Five of 34 children (15%) had activated protein C resistance; each was heterozygous for the factor V Leiden mutation. All 5 children heterozygous for the factor V Leiden mutation suffered non-CNS venous thromboses comprising 21% of the group of children (5/24) with non-CNS venous thrombotic events. Each of these 5 children had a family history of thrombosis. In conclusion, children with non-CNS venous thrombosis should be evaluated for the factor V Leiden mutation. Children most likely affected are those with a family history of thrombosis.
Subject(s)
Factor V/analysis , Protein C/genetics , Thrombosis/genetics , Adolescent , Antithrombin III Deficiency , Blood Coagulation , Child , Female , Humans , Male , Partial Thromboplastin Time , Point MutationABSTRACT
A factor V506 Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively collected umbilical cord blood samples. The incidence of activated protein C resistance in cord blood was 6%. The sensitivity and specificity of the modified assay for the factor V Leiden mutation was 100%.
Subject(s)
Factor V/metabolism , Infant, Newborn/blood , Partial Thromboplastin Time , Protein C/pharmacology , Amino Acid Substitution , Arginine , Drug Resistance , Humans , Mutation , Sensitivity and SpecificityABSTRACT
Thromboembolic phenomena, frequently observed in children with cancer who are undergoing chemotherapy, can cause significant morbidity and, less frequently, mortality. Many contributory factors have been identified. Whether the recently identified and most common coagulation defect predisposing to thrombosis, factor V Leiden, is associated with thrombosis in this setting, has not been explored. The current study was undertaken to determine the prevalence of the factor V Leiden mutation in children with cancer who developed thromboembolic phenomena as compared to those with cancer who did not. Genomic DNA was amplified using the polymerase chain reaction (PCR), followed by digestion of the amplification product with the restriction enzyme MnlI. The digested PCR products were then size-fractionated to classify samples as heterozygous, homozygous or normal for the factor V Leiden mutation. 67 children with cancer were evaluated for the factor V Leiden mutation. One of 32 children with cancer and thrombosis, and none of 35 who had not experienced thrombotic problems, was found heterozygous for this mutation. We conclude that the factor V Leiden mutation does not play a significant role in the overall incidence of thromboses that occur in children with cancer.
Subject(s)
Factor V/genetics , Mutation , Neoplasms/genetics , Thrombosis/genetics , Adolescent , Blood Coagulation Disorders/blood , Blood Coagulation Disorders/complications , Blood Coagulation Disorders/genetics , Child , Child, Preschool , Female , Humans , Infant , Male , Neoplasms/blood , Neoplasms/complications , Polymerase Chain Reaction , Thromboembolism/blood , Thromboembolism/complications , Thromboembolism/genetics , Thrombosis/blood , Thrombosis/complicationsABSTRACT
OBJECTIVE: To determine whether resistance to activated protein C caused by the factor V Leiden mutation (Arg506 to Gln) is associated with thrombosis occurring during childhood. STUDY DESIGN: Children with thrombosis were screened for activated protein C resistance. Children found resistant to activated protein C had DNA analysis for the factor V Leiden mutation. Family members of the children with activated protein C resistance were similarly studied. RESULTS: Three of fourteen children examined had abnormal normalized activated protein C sensitivity ratios. One child had protein S deficiency. The children had hyperlipidemia. Molecular confirmation of the factor V Leiden mutation was obtained for all three children. Family members of each of the three children were affected. CONCLUSIONS: Children have thromboses in association with the factor V Leiden mutation, as do adults. This mutation may be identified as an isolated risk factor or in association with other risk factors for thrombosis.
Subject(s)
Factor V/genetics , Thrombosis/genetics , Adolescent , Adult , Blood Coagulation Tests , Case-Control Studies , Child , Female , Humans , Male , Mutation , Pedigree , Protein C/metabolism , Risk Factors , Thrombosis/blood , Thrombosis/epidemiologyABSTRACT
The main purpose of this study was to determine the effect of mass media advertisement of food products (TV, radio and the press), particularly in pre-school and school-age children, as well as the concomitant impact these age groups have on the family food buying patterns. To test the hypothesis that the impact of mass media advertising on foods varied in the different socioeconomic levels of a community, a stratified sample of all children below 13 years of age, who attended the Francisco Fajardo school in the central coast of Venezuela, was drawn. Mass media contact, food and nutrition knowledge and other socioeconomic characteristics were related to the family's food-buying patterns. More specifically, the age, working status and educational level of the mother in regard to beliefs concerning the nutritional value of advertized food products, were related. A semi-structured questionnaire was designed, tested and applied to the housewife or whoever performed this role within the family. Findings revealed that families of low socioeconomic status are prone to be most influenced by mass media food product advertising. This is reflected not only in food purchasing practices but also in food consumption patterns at the family level. Chocolate drinks, cereals, jello, sausages, and ice cream are the most popular products among pre-school and school-aged children, without social class distinction. Furthermore, results revealed that the degree of exposure to mass communication media--television, radio and newspapers--is a determining factor in children's food preferences at all socioeconomic levels, and that television is the media exerting the greatest influence.
