ABSTRACT
Atopic dermatitis predisposes to skin infections, and on the other hand, some therapies used for atopic dermatitis may worsen viral infections whose lesions may be more diffuse and resistant to treatment. The authors present a patient with severe atopic dermatitis and disseminated molluscum contagiosum infection. The molluscum contagiosum did not clear with topical treatment, and it worsened her atopic dermatitis even more, so the authors started treatment with dupilumab. After two months, the patient's dermatitis went into clinical remission and there was resolution of the infection with no recurrence at the 12-month follow-up. Dupilumab is nowadays a promising treatment for severe atopic dermatitis. To our knowledge, only four reports of molluscum contagiosum during dupilumab therapy have been reported in the literature, with contrasting effects. According to the authors' experience, treatment with dupilumab appears to be a safe alternative for patients with severe atopic dermatitis who are also infected with molluscum contagiosum, as opposed to other treatments such as systemic corticosteroids or cyclosporine.
Subject(s)
Dermatitis, Atopic , Molluscum Contagiosum , Antibodies, Monoclonal, Humanized/therapeutic use , Dermatitis, Atopic/complications , Dermatitis, Atopic/drug therapy , Female , Humans , Molluscum Contagiosum/drug therapyABSTRACT
Abstract Atopic dermatitis predisposes to skin infections, and on the other hand, some therapies used for atopic dermatitis may worsen viral infections whose lesions may be more diffuse and resistant to treatment. The authors present a patient with severe atopic dermatitis and disseminated molluscum contagiosum infection. The molluscum contagiosum did not clear with topical treatment, and it worsened her atopic dermatitis even more, so the authors started treatment with dupilumab. After two months, the patient's dermatitis went into clinical remission and there was resolution of the infection with no recurrence at the 12-month follow-up. Dupilumab is nowadays a promising treatment for severe atopic dermatitis. To our knowledge, only four reports of molluscum contagiosum during dupilumab therapy have been reported in the literature, with contrasting effects. According to the authors' experience, treatment with dupilumab appears to be a safe alternative for patients with severe atopic dermatitis who are also infected with molluscum contagiosum, as opposed to other treatments such as systemic corticosteroids or cyclosporine.
ABSTRACT
Se trata de una mujer de 40 años, sin antecedentes de acné juvenil, que notó la aparición a los 37 años de múltiples pápulas asintomáticas, duras, en ambas mejillas. El estudio histopatológico mostró que se trataba de osteomas. (AU)
Subject(s)
Adult , Female , Humans , Face/pathology , Histological Techniques , Osteoma/diagnosis , Osteoma/etiology , Osteoma/surgery , Lasers/therapeutic use , Skin Manifestations , Skin Tests/methods , Skin Tests , Osteoma/pathology , Osteoma/epidemiology , Calcium/analysis , Phosphorus/analysis , Vitamin D/analysisABSTRACT
La dermatoscopia o microscopía de epiluminiscencia es una técnica complementaria de la exploración clínica, rápida y no invasiva que aumenta la precisión diagnóstica de los tumores cutáneos pigmentados. El conocimiento de los diferentes patrones dermatoscópicos permite, en ocasiones, diferenciar el melanoma de un grupo de lesiones que clínica y/o evolutivamente se comportan como simuladores de melanoma. Presentamos el caso de un varón de 32 años que desarrolló una lesión pigmentada de escaso tiempo de evolución, de crecimiento progresivo, cuya imagen dermatoscópica mostraba múltiples extensiones periféricas digitiformes, adoptando un patrón 'en llamarada' sugestivo de nevo de Reed, aunque con algún dato atípico que obligó a descartar un melanoma incipiente mediante el estudio histológico. Comentamos la utilidad de la dermatoscopia en el diagnóstico de este grupo de lesiones y los diferentes patrones dermatoscópicos que puede presentar el nevo de Reed (AU)
Subject(s)
Adult , Male , Humans , Melanoma/complications , Melanoma/diagnosis , Melanoma/therapy , Microscopy/methods , Nevus, Pigmented/classification , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Melanoma/pathology , Diagnosis, Differential , Melanocytes/pathology , Neoplasm Staging/methodsSubject(s)
Humans , Female , Aged , Carcinoma, Merkel Cell/diagnosis , Thigh , Carcinoma, Merkel Cell/surgery , Lymph Node Excision , Phosphopyruvate HydrataseABSTRACT
La corrección de defectos de gran tamaño localizados en el dorso y la punta nasales tras la extirpación de lesiones tumorales debe realizarse mediante colgajos locales o a distancia. Éstos aportan un tejido de gran similitud en textura, color y grosor superior al proporcionado por los injertos de piel. El colgajo frontonasal descrito por Marchac es una variante del colgajo pannasal de Rieger que incorpora una excelente vascularización axial a través de la arteria angular. Esta modificación aumenta la movilidad, permitiendo un amplio descenso y rotación para la cobertura de defectos en la punta nasal. Aportamos el caso de una mujer de 80 años que presentaba un carcinoma basocelular de gran tamaño localizado en tercio distal del dorso y la punta nasales. Tras la extirpación se empleó un colgajo axial frontonasal para la corrección del defecto resultante, obteniéndose un excelente resultado cosmético. Describimos la técnica y comentamos las ventajas que aporta en cirugía reconstructiva nasal (AU)
