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Bioorg Med Chem Lett
; 15(24): 5537-43, 2005 Dec 15.
Article
in English
| MEDLINE
| ID: mdl-16202593
ABSTRACT
In order to fully explore structure-activity relationships at the 1- and 2-positions of the piperazine core of tricyclic farnesyltransferase inhibitors, an 11,718-member ECLiPS library was synthesized and screened in a farnesyltransferase scintillation proximity assay. A detailed description of the library and analyses of the screening data will be provided.