ABSTRACT
Conflicting results have emerged from studies using oral and rectal disodium cromoglycate (DSCG) in inflammatory bowel disease. In the present double-blind study, 43 patients with active ulcerative proctosigmoiditis received either placebo (n = 22) or 600 mg DSCG (n = 21) rectally as enemas for eight weeks. Assessment was made from clinical investigations, endoscopy, laboratory tests, biopsies, and diary cards. No statistically significant differences in bowel frequency, rectal bleeding, general well-being, abdominal pain, and severity and extent of the disease were found between the groups during the study. There was no significant change in the histologic parameters. No side-effect was encountered. It is concluded that DSCG did not improve symptoms or inflammatory changes in ulcerative proctosigmoiditis.
Subject(s)
Colitis/drug therapy , Cromolyn Sodium/administration & dosage , Proctocolitis/drug therapy , Adolescent , Adult , Aged , Clinical Trials as Topic , Double-Blind Method , Enema , Female , Humans , Male , Middle Aged , Rectum , TabletsSubject(s)
Brucellosis/diagnosis , Adult , Agglutination Tests , Diagnosis, Differential , Humans , Italy , Male , Norway , Yersinia Infections/diagnosisABSTRACT
A 48 year old female patient with intestinal malabsorption and subtotal to total jejunal villous atrophy also had granulomatous inflammation characterised by numerous epitheloid and giant cell granulomas in the stomach, the jejunum, and the liver, On a gluten-free diet a complete remission was achieved that included disappearance of the granulomatous inflammation. It is suggested that the granulomas in this case were manifestations of the gluten intolerance.
Subject(s)
Celiac Disease/diet therapy , Glutens , Granuloma, Giant Cell/diet therapy , Celiac Disease/complications , Female , Gastric Mucosa/pathology , Gastrointestinal Diseases/pathology , Granuloma, Giant Cell/complications , Humans , Jejunum/pathology , Liver/pathology , Liver Diseases/diet therapy , Middle AgedABSTRACT
The incidence of dumping has varied from 1 to 75% in a number of reported series. The discrepancy probably depends mainly on different definitions of the dumping syndrome. In the present work, the clinical diagnostic index (CDI) first proposed by Sigstad in 1968, has been used in a follow-up study of 241 patients after gastric resection for ulcer disease. 86% of the patients were satisfied with the result of the operation. Dumping occurred daily in 14.1% and 19.5% had the symptoms occasionally. The differences in the frequency of dumping after BI and BII resection were not statistically significant, gastro-jejunal fixation (GJF) and the position of the anastomosis had no influence on the prognosis.
