ABSTRACT
A solid target system was developed for a PET cyclotron. The system is compatible with many different target materials in the form of foils and electroplated/sputtered targets which makes it useful for production of a wide variety of different PET radionuclides. The target material is manually loaded into the system. Remote handling of irradiated target material is managed with a pneumatic piston and a vacuum technique which allows the targets to be dropped into a shielded transport container. To test the target performance, proton irradiations (12.8 MeV, 45 µA) of monoisotopic yttrium foils (0.64 mm, direct water cooling) were performed to produce 89Zr. The yields were 2200±200 MBq (1 h, n=13) and 6300±65 MBq (3 h, n=3).
Subject(s)
Cyclotrons/instrumentation , Isotope Labeling/instrumentation , Positron-Emission Tomography/instrumentation , Radioisotopes/chemistry , Robotics/instrumentation , Specimen Handling/instrumentation , Zirconium/chemistry , Equipment Design , Equipment Failure Analysis , Radiation Dosage , Radioisotopes/radiation effects , Radiometry/instrumentation , Zirconium/radiation effectsABSTRACT
A [(18)F]Fluoride water target was constructed for a Scanditronix MC 17 cyclotron, without a beam line, with a typical wide beam of â¼30 × 5 mm(2). Niobium was used as target chamber material. One hour irradiation with 45µA protons yields about 110 GBq [(18)F]Fluoride. The saturation yield is 8.0 ± 0.6 GBq/µA (EOB). The FDG yield is 60 ± 5% (EOS) with a TracerLab MX (G.E. Healthcare). More than 100 GBq FDG is routinely produced after a 2h irradiation.
