The prevalence of Borrelia burgdorferi seropositivity in an area endemic for Lyme disease.

We conducted a seroprevalence survey of antibodies to Borrelia burgdorferi in West Central Wisconsin, an area endemic for Lyme disease. One hundred and thirty-seven of 153 patients having blood drawn at the Eau Claire Family Medicine Clinic and the associated rural Augusta practice participated in the study and were tested for the presence of antibodies to B burgdorferi and questioned about Lyme disease risk factors. An enzyme-linked immunosorbent assay showed that 15 (10.9%) of the 137 persons had serological evidence of exposure to B burgdorferi. None of these 15 persons reported a past or current history of clinical Lyme disease, and they were not found to have more symptoms commonly associated with Lyme disease than seronegative patients. We conclude that the prevalence of positive Lyme serologies in this area is similar to that of other endemic areas and that subclinical or asymptomatic infection probably accounts for many of these positive results.

Patient acceptance of prenatal alpha-fetoprotein screening: a preliminary study.

Forty-five obstetrical patients who received an educational session about maternal serum alpha-fetoprotein (MSAFP) screening were followed until the 20th to 26th week of gestation to determine what percentage would decide to have MSAFP testing. These patients were then given a knowledge test and questioned about the factors that led to their decision about the test. Fourteen of the 45 study patients (31%) elected to have MSAFP testing. The patient's decision to have MSAFP testing was found to be significantly associated with 1) reporting a longer length of time discussing the test with the physician, 2) reporting that the opinion of a significant other about the test was important, and 3) older age. There is a need for further study of patients' acceptance of MSAFP testing to see if the relatively low acceptance rate found in this study is also found in other practices.