Subject(s)
Echocardiography, Doppler, Color , Echocardiography, Transesophageal , Embolism, Paradoxical/diagnostic imaging , Foramen Ovale, Patent/diagnostic imaging , Pulmonary Embolism/diagnostic imaging , ST Elevation Myocardial Infarction/diagnostic imaging , Adult , Angioplasty, Balloon, Coronary/instrumentation , Coronary Angiography , Electrocardiography , Embolism, Paradoxical/etiology , Female , Foramen Ovale, Patent/complications , Humans , Pulmonary Embolism/etiology , ST Elevation Myocardial Infarction/etiology , ST Elevation Myocardial Infarction/therapy , StentsABSTRACT
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study. Patients admitted for STEMI were enrolled according to prespecified inclusion and exclusion criteria. The primary endpoint was device-oriented composite endpoint (DOCE), including cardiac death, target-vessel myocardial infarction, and target-lesion revascularization (TLR) within 30 days of the index procedure. Secondary endpoints were procedural success, any probable/definite scaffold thrombosis, and DOCE at subsequent follow-up. RESULTS: From December 1, 2016 to October 30, 2017, a total of 18 patients were included. Follow-up data were available for 17 patients (94%). There was no primary endpoint event. Procedural success was 100%. Patients were followed for a median of 153 days (range, 59-326 days). Over that extended follow-up period, 1 case of TLR occurred 102 days after the index procedure. There was no case of definite or probable scaffold thrombosis. CONCLUSIONS: This pilot study is the first to assess feasibility and clinical outcomes associated with RMS implantation in selected STEMI patients. The results seem reassuring, with favorable short-term clinical outcomes and absence of definite/probable scaffold thrombosis, and should prompt further research including randomized controlled trials evaluating RMS implantation in the setting of STEMI.
Subject(s)
Drug-Eluting Stents/adverse effects , Magnesium/administration & dosage , Percutaneous Coronary Intervention/methods , ST Elevation Myocardial Infarction/surgery , Absorbable Implants/adverse effects , Adult , Aged , Female , Follow-Up Studies , Humans , Magnesium/adverse effects , Male , Middle Aged , Percutaneous Coronary Intervention/adverse effects , Pilot Projects , Prospective Studies , Prosthesis Design/adverse effects , Prosthesis Design/methods , Treatment OutcomeSubject(s)
Arthroplasty, Replacement, Hip/adverse effects , Embolism, Paradoxical/diagnostic imaging , Foramen Ovale, Patent/diagnostic imaging , Pulmonary Embolism/etiology , Thrombectomy/methods , Aged , Arthroplasty, Replacement, Hip/methods , Dyspnea/diagnosis , Dyspnea/etiology , Echocardiography/methods , Echocardiography, Transesophageal/methods , Embolism, Paradoxical/etiology , Embolism, Paradoxical/surgery , Emergency Service, Hospital , Female , Follow-Up Studies , Humans , Magnetic Resonance Angiography/methods , Pulmonary Embolism/diagnostic imaging , Pulmonary Embolism/surgery , Risk Assessment , Tomography, X-Ray Computed/methods , Treatment OutcomeABSTRACT
Chagas disease is caused by the parasite Trypanosoma cruzi, and mostly affects poor rural populations of central and south America. It is mainly acquired by bugs (triatoma) but also by ingestion of the parasite (fresh fruit juices) or by foetal-maternal blood passing. Despite an important decrease in transmission during the last decades in several countries, millions of patients are still chronically infected and most of them are asymptomatic. In 2012-2013, two cases were admitted in our cardiac intensive care unit (ICU) with heart block due to Chagas cardiomyopathy. Diagnosis was established by echocardiography and positive serological results for Trypanosoma cruzi. This report underlines that in cases of heart failure and conduction abnormalities of unclear aetiology, Chagas disease should be taken into consideration, even in patients originating from non-endemic countries.
Subject(s)
Atrioventricular Block/diagnosis , Atrioventricular Block/parasitology , Bundle-Branch Block/diagnosis , Bundle-Branch Block/parasitology , Chagas Disease/diagnosis , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Parasitic/diagnosis , Trypanosoma cruzi/isolation & purification , Adrenergic beta-Antagonists/therapeutic use , Adult , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Animals , Atrioventricular Block/ethnology , Atrioventricular Block/therapy , Belgium , Brazil/ethnology , Bundle-Branch Block/drug therapy , Bundle-Branch Block/ethnology , Chagas Cardiomyopathy/diagnosis , Chagas Disease/ethnology , Chagas Disease/parasitology , Chagas Disease/transmission , Disease Vectors , Diuretics/therapeutic use , Drug Therapy, Combination , Emigration and Immigration , Female , Follow-Up Studies , Humans , Male , Pacemaker, Artificial , Pregnancy , Pregnancy Complications, Cardiovascular/drug therapy , Pregnancy Complications, Cardiovascular/ethnology , Pregnancy Complications, Parasitic/drug therapy , Pregnancy Complications, Parasitic/ethnology , Treatment OutcomeABSTRACT
This is a rare case of Aspergillus myocardial abscess in 19-year-old woman with acute lymphoblastic leukemia treated by chemotherapy. During pancytopenia she developed invasive aspergillosis with myocardial abscess. The presence of specific antigen in the pericardial effusion was diagnostic. She died despite vigorous antifungal therapy.
Subject(s)
Aspergillosis/diagnostic imaging , Echocardiography/methods , Myocarditis/diagnostic imaging , Adult , Female , Humans , Rare Diseases/diagnostic imagingABSTRACT
BACKGROUND: The apical ballooning syndrome is precipitated by emotional or physical stress but the underlying mechanism remains poorly understood. The contribution of myocardial bridging on the aetiology and the onset of the syndrome is not known. METHODS: We observed 8 patients with chest pain, T-wave inversion in several leads of the ECG, transient left ventricular apical ballooning and no significant angiographic stenosis. RESULTS: There were 7 women and I man. The median age was 67.5 years. Seven patients had an intense emotional or physical stress (87.5%). All patients presented with chest pain and aT-wave inversion in the precordial leads. The median elevation of creatine-kinase was 171 IU. In all patients, echocardiography showed an alteration of the left ventricular function with a very extensive apical akinesia. Left ventricular hypertrophy was observed in 7 patients. A myocardial bridging in the mid segment of the left anterior descending coronary artery was observed in 5 patients (62.5%). Recovery was complete in all patients. During follow-up, no patient showed recurrence. CONCLUSIONS: Our data suggest that myocardial bridging possibly enhanced by catecholamines during stress may contribute, in association with left ventricular hypertrophy, to the preferential apical localization of the apical ballooning syndrome. Further investigations are necessary to confirm