ABSTRACT
This survey shows that among chronic heart failure (CHF) and its characteristic inflammation observed mutual activation. Given the role of inflammation in the pathophysiology of heart failure, it is to study how the combination drug treatment of CHF, its variants influence on markers of inflammation. It is expedient to determine not only the level of cytokines, but also acute phase proteins (haptoglobin, seroglikoidy C3-complement, transferrin), reflecting inflammation and necrosis in the connective tissue, as well as IgA, IgG, IgM and protein spectrum. The importance of the study of haptoglobin due to its involvement in the metabolism of hemoglobin and transferrin--the exchange of iron.
Subject(s)
Heart Failure/immunology , Immune System/metabolism , Acute-Phase Proteins/metabolism , Biomarkers/blood , Chronic Disease , Complement C3/metabolism , Cytokines/blood , Haptoglobins/metabolism , Heart Failure/blood , Heart Failure/complications , Heart Failure/pathology , Humans , Immune System/pathology , Inflammation/blood , Inflammation/complications , Inflammation/immunology , Inflammation/pathology , Transferrin/metabolismABSTRACT
Found that different versions of the combined drug therapy of chronic heart failure accompanied by an increase of erythrocytes, hemoglobin in the blood of patients, color index, tended to increase hematocrit. The most pronounced changes are marked valid in the group of patients receiving the combination of ACE inhibitors + ARB-II + beta-blockers + diuretics. Found to have a direct positive correlation between hemoglobin levels and distance 6-minute test, the back - between hemoglobin and end-diastolic volume of the left ventricle, the functional class of heart failure. The number of red blood cells inversely correlated with functional class of heart failure, a direct positive - with a distance of 6-minute test.
