ABSTRACT
Aymara Amerindians from the Titicaca Lake Andean highlands are studied for HLA-A, HLA-B, HLA-DRB1 and HLA-DQB1 gene frequencies. Genetic distances, neighbour-joining and correspondence analyses are performed by using other Amerindian and worldwide populations (15384 chromosomes are studied). The HLA genetic profile of Aymaras is different from neighbouring and language-related Quechuas (Incas). Both Quechuas and Aymaras seem to present an HLA-DRB1*0901 high frequency, which is present in a very low frequency or absent in Mesoamericans (Mazatecans, Mayans) and most studied Amerindians. Moreover, it is observed a closer relatedness of Aymaras with Amerindians from the Amazon Basin and Chaco lowlands, compared to Quechuans.
Subject(s)
American Indian or Alaska Native/genetics , HLA Antigens/genetics , Histocompatibility Antigens Class II/genetics , Histocompatibility Antigens Class I/genetics , Bolivia , Gene Frequency , Haplotypes , HumansABSTRACT
Se estudia a 75 Jefes de Familia, Padres de Pacientes internados por diferentes patologias en el Hospital de Niños "Dr. M.O.S." catalogado segun su condicion socioeconomica, como "pobres, en los aspectos de salud, educacion vivienda que repercuten en la salud y/o recuperacion de los pacientes internados.
