ABSTRACT
The satisfied differential distinctions between diseases (7 nosological groups) observed in population of so-called Ural radiation trace are established using laser correlation spectroscopy (LCS). Unsatisfied differentiation (less then 65%) was observed between cancer and pre-cancer diseases relative to gastric, bronchial and exchange pathologies. The most significant distinctions are established for autoimmune pathologies and osteochondroses and for cancer and pre-cancer differentiation. Marked differentiation degree is less than that earlier registered between the same pathologies in regions, where radiation level was normal. On the base of the measurements is planned to study the dose effect of pathology radiomodification.
Subject(s)
Lasers , Neoplasms, Radiation-Induced/diagnosis , Precancerous Conditions/diagnosis , Radiation Injuries/diagnosis , Radioactive Fallout/adverse effects , Spectrum Analysis/methods , Autoimmune Diseases/blood , Autoimmune Diseases/classification , Autoimmune Diseases/diagnosis , Chronic Disease , Diagnosis, Differential , Environmental Monitoring , Homeostasis/radiation effects , Humans , Neoplasms, Radiation-Induced/blood , Neoplasms, Radiation-Induced/classification , Precancerous Conditions/blood , Precancerous Conditions/classification , Radiation Injuries/blood , Radiation Injuries/classification , Risk Factors , RussiaABSTRACT
LCS presents information on the size distribution of particles in analysed objects. LCS of blood plasma was performed in 26 patients with stomach bleedings, 19 with brain injuries, 13 with chronic hepatitis, 149 with chronic chlorophos intoxication and 45 healthy subjects. Spectra of blood plasma from patients with stomach bleeding differed significantly from those of healthy subjects. Spectra of blood plasma from patients with brain injuries differed from those of alcohol poisoning patients. The size distribution of particles in the blood plasma alcohol poisoning patients was similar to that of the patients with chronic hepatitis or chronic chlorophos intoxication perhaps because of liver function disturbances in all these cases. These results allow LCS to be offered as a diagnostic method.
Subject(s)
Alcoholic Intoxication/blood , Brain Injuries/blood , Lasers , Peptic Ulcer Hemorrhage/blood , Peptic Ulcer/complications , Spectrum Analysis/methods , Trichlorfon/poisoning , Adult , Blood Donors , Chronic Disease , Female , Hepatitis/blood , Humans , Male , Middle Aged , Peptic Ulcer/blood , Poisoning/bloodABSTRACT
LCS was performed in 35 patients with mammary cancer, 59 patients with benign breast tumours and 35 healthy people. 39 samples were taken from inhabitants of Odessa, 89 from St.-Petersburg. Differences were discovered between blood plasma spectra of Odessa and St.-Petersburg residents. Spectra of blood plasma in patients with mammary tumours differed from those of healthy people. LCS may be used for screening, for forming the groups of risk and for diagnosis of mammary gland tumours.
Subject(s)
Breast Neoplasms/blood , Lasers , Plasma/chemistry , Spectrum Analysis/methods , Blood Donors , Female , Humans , Russia , Spectrum Analysis/instrumentation , Ukraine , Urban PopulationABSTRACT
In 30 patients with myasthenia the authors studied the dynamic of changes of subfraction content of the blood serum using the method of laser correlation spectroscopy. Significant changes of the blood serum homeostasis have been revealed in the process of hemosorption. The obtained results make it possible to develop objective criteria for indications to hemosorption as well as for the assessment of the efficacy of therapy.
Subject(s)
Hemoperfusion , Lasers , Myasthenia Gravis/blood , Spectrum Analysis/methods , Adolescent , Adult , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Hemoperfusion/instrumentation , Hemoperfusion/methods , Homeostasis , Humans , Middle Aged , Myasthenia Gravis/therapy , ThymectomyABSTRACT
As early as 60 mi after gamma-irradiation of Wistar rats with a dose of 150 Gy the content of serotonin and 5-hydroxyindoleacetic acid decreases in the midbrain, hippocampus, and cerebral hemisphere cortex. The decrease is most pronounced in the midbrain where serotoninergic neurons are located. The changes are accumulated during the first 24 h following irradiation.
Subject(s)
Brain/radiation effects , Radiation Injuries, Experimental/metabolism , Serotonin/metabolism , Animals , Brain/metabolism , Hydroxyindoleacetic Acid/metabolism , Radiation Dosage , Rats , Rats, Inbred StrainsABSTRACT
A transient form of acute radiation sickness could be distinguished in Wistar rats after total-body exposure to 60Co-gamma-rays in high doses (150-200 Gy). With local exposure of head, in addition to direct damaging effect on the nervous system, the organismic factors play an important role in the development of the CNS syndrome. Effects of fractionation of superhigh doses of gamma-quanta and fission neutrons were not observed. The RBE of neutrons should constitute 1.8 for the transient form of radiation sickness to develop. This value is much lesser than that needed for the development of haemopoietic and intestinal lesions. PAPP, "gammaphos" and the combination of these agents do not influence the affection of rats by high doses of gamma-quanta.
Subject(s)
Radiation Injuries, Experimental/mortality , Amifostine/therapeutic use , Animals , Cobalt Radioisotopes , Dose-Response Relationship, Radiation , Gamma Rays , Male , Neutrons , Propiophenones/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Rats , Rats, Inbred Strains , Relative Biological EffectivenessABSTRACT
The anterior hypophysis (AH) of rat exposed to total cooling at --10 degrees C for 6 min was studied histologically and autoradiographically. 3, 6, 12, 18, and 24 hours after the exposure the diurnal cycle of modifications of the functional state of the AH secretory cells, the number of mitoses and of the labeled DNA-synthesizing cells was traced. In 12 hours a considerable activation of the thyrotrops and a doubling of mitoses occurred; there was no change of the labeled cells index for twenty four hours. The data obtained showed that stress reaction to cold was characterized by the intensification of the thyrotropic function and an acceleration of mitotic process in the AH cells.
Subject(s)
Cold Temperature , Pituitary Gland, Anterior/physiology , Animals , Circadian Rhythm , DNA/biosynthesis , Male , Mitosis , Pituitary Gland, Anterior/cytology , Pituitary Gland, Anterior/metabolism , Rats , Time FactorsABSTRACT
The adenohypophysis of intact mongrel male rats was studied histologically and autoradiographically. The diurnal periodicity was revealed and the successive spikes of indices of the DNA synthesis, mitotic process and secretory activity of the adenohypophysis cells were established. The maximum amount of the dividing cells was found about 12 o'clock p. m.-at the period of the least secretory and synthetizing activity of the gland.