ABSTRACT
BACKGROUND: The purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC). METHODS: One hundred twenty-three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death. RESULTS: There were 54 recurrences (43.9%) and 75 deaths (60.9%). The mean tumor volume among the patients living without disease during the follow-up period was 28.2 cc, compared to 88.2 cc for patients living with disease, and to 78.9 cc for patients who died of the disease (p < .001). Multivariate analyses showed that volume and perineural invasion were independent factors for recurrence, whereas volume and lymph node metastasis were independent factors for death. CONCLUSION: Among patients who already have advanced cancers, tumor volume can significantly impact their prognoses. © 2017 Wiley Periodicals, Inc. Head Neck 39: 960-964, 2017.
Subject(s)
Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/mortality , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local/epidemiology , Aged , Carcinoma, Squamous Cell/therapy , Cross-Sectional Studies , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Mouth Neoplasms/therapy , Neoplasm Invasiveness , Risk Factors , Survival Rate , Tumor BurdenABSTRACT
BACKGROUND: Patients who experience massive weight loss often require a thighplasty procedure to reduce excess skin and reshape thighs and lower body contour, improving movement, hygiene, posture, self-image, and quality of life. METHODS: After weight loss and stabilization of weight, eight patients in the postoperative period of gastric bypass were subjected to a thighplasty. Measurements of upper and lower circumferences of the thighplasty and thigh heights were obtained in the preoperative and postoperative periods of 60 and 180 days for comparison of volume change after the surgical procedure. RESULTS: The average volume reduction of each thigh at a postoperative period of 180 days was 1,135 cm³ or 1.135 liters. All patients had small areas of dehiscence along the scars on the medial thigh, and dressings were applied for healing by secondary intention. One (12.5 percent) patient had cysts in both thighs, confirmed by ultrasound, and required surgical intervention for resection and subsequent resolution. CONCLUSIONS: It was possible to demonstrate significant reduction in the volume of each thigh after plastic surgery for contour refitting. Patient satisfaction and complications associated with the procedures performed were also documented.
INTRODUÇÃO: Pacientes que apresentam perda maciça de peso muitas vezes precisam reduzir o excesso de pele e remodelar o contorno das coxas e parte inferior do corpo, melhorando os movimentos, higiene, postura, autoimagem e qualidade de vida. MÉTODO: Oito pacientes em pós-operatório de gastroplastia redutora, após perda e estabilização do peso, foram submetidas a coxoplastia. Medidas das circunferências superior e inferior e da altura das coxas foram obtidas em pré-operatório e pós-operatório de 60 dias e 180 dias, para comparação de alteração de volume consequente ao procedimento cirúrgico. RESULTADOS: A redução média de volume de cada coxa, aos 180 dias de pós-operatório, foi de 1.135 cm³ ou 1,135 litro. Todas as pacientes apresentaram pequenas deiscências ao longo das cicatrizes em face medial das coxas, sendo realizados curativos com cicatrização por segunda intenção. Uma (12,5 por cento) paciente apresentou cistos em ambas as coxas, confirmados por ultrassonografia, sendo necessária intervenção cirúrgica para ressecção e consequente resolução. CONCLUSÕES: Foi possível demonstrar redução significativa do volume de cada coxa após cirurgia plástica para readequação do contorno, além de documentar a satisfação das pacientes e as complicações associadas aos procedimentos realizados.
