ABSTRACT
Traumatic brain injury (TBI) is the main cause of trauma-related deaths. Systemic hypotension and intracranial hypertension causes cerebral ischemia by altering metabolism of prostanoids. We describe prostanoid, pupilar and pathological response during resuscitation with hypertonic saline solution (HSS) in TBI. Method Fifteen dogs were randomized in three groups according to resuscitation after TBI (control group; lactated Ringer's (LR) group and HSS group), with measurement of thromboxane, prostaglandin, macroscopic and microscopic pathological evaluation and pupil evaluation.Result Concentration of prostaglandin is greater in the cerebral venous blood than in plasma and the opposite happens with concentration of thromboxane. Pathology revealed edema in groups with the exception of group treated with HSS.Discussion and conclusion There is a balance between the concentrations of prostaglandin and thromboxane. HSS prevented the formation of cerebral edema macroscopically detectable. Pupillary reversal occurred earlier in HSS group than in LR group.
Subject(s)
Brain Injuries/drug therapy , Fluid Therapy/methods , Prostaglandins F/blood , Pupil/physiology , Saline Solution, Hypertonic/therapeutic use , Shock, Hemorrhagic/therapy , Animals , Brain/metabolism , Brain/pathology , Brain Edema/prevention & control , Brain Injuries/metabolism , Cerebrovascular Circulation/physiology , Dogs , Hemodynamics/physiology , Intracranial Pressure , Isotonic Solutions/therapeutic use , Male , Random Allocation , Reproducibility of Results , Ringer's Lactate , Shock, Hemorrhagic/metabolism , Thromboxane B2/blood , Time Factors , Treatment OutcomeABSTRACT
Traumatic brain injury (TBI) is the main cause of trauma-related deaths. Systemic hypotension and intracranial hypertension causes cerebral ischemia by altering metabolism of prostanoids. We describe prostanoid, pupilar and pathological response during resuscitation with hypertonic saline solution (HSS) in TBI. Method Fifteen dogs were randomized in three groups according to resuscitation after TBI (control group; lactated Ringer’s (LR) group and HSS group), with measurement of thromboxane, prostaglandin, macroscopic and microscopic pathological evaluation and pupil evaluation.Result Concentration of prostaglandin is greater in the cerebral venous blood than in plasma and the opposite happens with concentration of thromboxane. Pathology revealed edema in groups with the exception of group treated with HSS.Discussion and conclusion There is a balance between the concentrations of prostaglandin and thromboxane. HSS prevented the formation of cerebral edema macroscopically detectable. Pupillary reversal occurred earlier in HSS group than in LR group.
O traumatismo cranioencefálico (TCE) é a principal causa de morte relacionada ao trauma. O choque hemorrágico e hipertensão intracraniana causam isquemia cerebral alterando o metabolismo de prostanóides. Neste estudo, relatamos o comportamento dos prostanóides, resposta pupilar e patologia durante a reposição volêmica com solução salina hipertônica (SSH) no TCE. Método Quinze cachorros foram randomizados em três grupos (controle, grupo de Ringer lactato e grupo de SSH) e foram avaliados tromboxane, prostaglandina, avaliação patológica macroscópica e microscópica e status pupilar.Resultado A concentração de prostaglandina é maior no sangue cerebral em comparação ao plasma, e o inverso ocorre com o tromboxane. A patologia revelou edema em todos os grupos, com exceção do grupo tratado com SSH.Discussão e conclusão Existe um equilíbrio entre concentrações cerebrais e plasmáticas de prostaglandina e tromboxane. A SSH protegeu o cérebro da formação de edema pós traumático.
Subject(s)
Animals , Dogs , Male , Brain Injuries/drug therapy , Fluid Therapy/methods , Prostaglandins F/blood , Pupil/physiology , Saline Solution, Hypertonic/therapeutic use , Shock, Hemorrhagic/therapy , Brain Edema/prevention & control , Brain Injuries/metabolism , Brain/metabolism , Brain/pathology , Cerebrovascular Circulation/physiology , Hemodynamics/physiology , Intracranial Pressure , Isotonic Solutions/therapeutic use , Random Allocation , Reproducibility of Results , Shock, Hemorrhagic/metabolism , Time Factors , Treatment Outcome , /bloodABSTRACT
The present paper highlighted the importance of the recommended levels of fish consumption or omega-3 supplementation in order to minimize the frequency of seizures in people with uncontrolled epilepsy and, especially, to reduce the occurrence of sudden unexpected death in epilepsy (SUDEP).
O presente trabalho destacou a importância dos níveis recomendados de consumo de peixe ou suplementação de ômega-3 com o intuito de minimizar a frequência de crises epilépticas em pessoas com epilepsia refratária e, especialmente, de reduzir a ocorrência de morte súbita inesperada em epilepsia (SUDEP).
Subject(s)
Humans , Death, Sudden/prevention & control , Epilepsy/prevention & control , /administration & dosage , Neuroprotective Agents/administration & dosage , Dietary Supplements , Death, Sudden/etiology , Epilepsy/complicationsABSTRACT
The present paper highlighted the importance of the recommended levels of fish consumption or omega-3 supplementation in order to minimize the frequency of seizures in people with uncontrolled epilepsy and, especially, to reduce the occurrence of sudden unexpected death in epilepsy (SUDEP).
Subject(s)
Death, Sudden/prevention & control , Epilepsy/prevention & control , Fatty Acids, Omega-3/administration & dosage , Neuroprotective Agents/administration & dosage , Death, Sudden/etiology , Dietary Supplements , Epilepsy/complications , HumansABSTRACT
Cardiology has been and is a very significant fraction of the Brazilian contribution to science. In older days, the most significant part of this work was directed to foreign periodicals, but the quasi-simultaneous emergence of SciELO and PUBMED has ordained a redirection of much of this work to Brazilian periodicals. We here survey some of this more recent contribution for the benefit of readers of Revista Brasileira de Cirurgia Cardiovascular. This is offered as an update. Articles on the general themes of Cardiology and Pneumology published by four ISI Indexed Brazilian journals not specializing in cardiology are re-visited, after a search through 10 journals.
A Cardiologia foi, e continua sendo, responsável por uma fracção muito significativa da contribuição brasileira para a ciência. No passado, os trabalhos mais importantes eram direcionados para periódicos estrangeiros, mas o surgimento quase simultâneo do SciELO e PUBMED facilitou um redirecionamento de grande parte desses trabalhos a periódicos brasileiros. Neste artigo, examinamos algumas das contribuições mais recentes em benefício aos leitores da Revista Brasileira de Cirurgia Cardiovascular. Esta discussão é oferecida como uma atualização. Artigos sobre os temas gerais da cardiologia e pneumologia publicados por quatro revistas brasileiras indexadas no ISI - não especializadas em cardiologia - são revistos.
Subject(s)
Humans , Bibliometrics , Biomedical Research/statistics & numerical data , Cardiology/statistics & numerical data , Periodicals as Topic/statistics & numerical data , Brazil , PublishingABSTRACT
In the last few years, a huge increment in the quality of scientific articles published in Brazilian Medical Journals has been observed. Several reasons were related to this feature including the SciELO free access initiative, the English language adopted by most journals, and, more importantly, the increase in the number and quality of Brazilian researchers. This article highlights, in the cardiovascular and respiratory areas, the best articles that have been published in these journals in the last few months. The reader will have a general overview of these areas and can select the original articles for deeper information.
Nos últimos anos, houve um aumento considerável na qualidade dos artigos científicos publicados em periódicos médicos brasileiros. As razões para tal incremento são muitas, incluindo a iniciativa de open access da base SciELO, a adoção do inglês por vários periódicos e, a mais relevante, o aumento em número e qualidade dos pesquisadores brasileiros. Este artigo indica os melhores artigos sobre os sistemas cardiovascular e respiratório publicados recentemente nesses periódicos. Será oferecido ao leitor um panorama dessas áreas e alguns artigos podem ser selecionados para maiores informações.
Subject(s)
Humans , Biomedical Research , Cardiovascular System , Respiratory System , Brazil , Cardiovascular Surgical Procedures , Periodicals as TopicABSTRACT
This review covers recent publications on the motor system (orthopedics and movement) in Brazilian journals recently admitted to the ISI-Thomson Journal of Citations Index. Two of these are still pleading for admission into PubMed which will eventually enhance their global visibility. We offer this contribution to experts on these areas who are regular readers of Revista da Associação Médica Brasileira. Full free copies of all of them are available at www.scielo.br. The main areas covered are orthopedics of limb articulations, fractures, movement, posture, gait, exercise and animal models.
Subject(s)
Orthopedics , Periodicals as Topic/statistics & numerical data , Biomedical Research , Brazil , Extremities/physiology , Humans , Locomotion , Spine/physiologyABSTRACT
This review covers recent publications on the motor system (orthopedics and movement) in Brazilian journals recently admitted to the ISI-Thomson Journal of Citations Index. Two of these are still pleading for admission into PubMed which will eventually enhance their global visibility. We offer this contribution to experts on these areas who are regular readers of Revista da Associação Médica Brasileira. Full free copies of all of them are available at www.scielo.br. The main areas covered are orthopedics of limb articulations, fractures, movement, posture, gait, exercise and animal models.
Esta revisão abrange publicações recentes sobre o sistema locomotor (ortopedia e movimento) em periódicos brasileiros recentemente incluídos na plataforma de citações ISI-Thomson. Dois destes periódicos ainda estão pleiteando inclusão no PubMed o que aumentará sua visibilidade. Oferecemos esta contribuição para especialistas nestas áreas de interesse e que são leitores regulares da Revista da Associação Médica Brasileira. Cópias integrais dos artigos citados estão disponíveis gratuitamente no site www.scielo.br. Os principais temas cobertos são ortopedia e articulações dos membros, fraturas, movimento, postura, marcha e modelos animais.
Subject(s)
Humans , Orthopedics , Periodicals as Topic/statistics & numerical data , Biomedical Research , Brazil , Extremities/physiology , Locomotion , Spine/physiologyABSTRACT
OBJECTIVE: Impact Factors (IF) are widely used surrogates to evaluate single articles, in spite of known shortcomings imposed by cite distribution skewness. We quantify this asymmetry and propose a simple computer-based procedure for evaluating individual articles. METHOD: (a) Analysis of symmetry. Journals clustered around nine Impact Factor points were selected from the medical ‘‘Subject Categories’’ in Journal Citation Reports 2010. Citable items published in 2008 were retrieved and ranked by granted citations over the Jan/2008 - Jun/2011 period. Frequency distribution of cites, normalized cumulative cites and absolute cites/decile were determined for each journal cluster. (b) Positive Predictive Value. Three arbitrarily established evaluation classes were generated: LOW (1.3Subject(s)
Humans
, Journal Impact Factor
, Periodicals as Topic/standards
, Quality Control
, Software
ABSTRACT
A brief review intended as information to the readership of Clinics on papers recently published under various medical headings in Brazilian scientific journals recently indexed or about to be indexed in ISI-THOMSON Journal Citation Reports. Journals covered in this review are Acta Ortopédica Brasileira, Arquivos Brasileiros de Cardiologia, Jornal Brasileiro de Pneumologia, Revista Brasileira de Cirurgia Cardiovascular and Revista da Associação Médica Brasileira.
