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Vertical transmission of HIV in Rio de Janeiro, Brazil.

João, Esaú Custódio; Cruz, Maria Letícia; Menezes, Jacqueline A; Matos, Haroldo J; Calvet, Guilherme A; d'Ippolito, Marcos M; Salgado, Luísa T; Silva, Sonia S; Bazin, Gabriela R; Braga, Ricardo C.

AIDS ; 17(12): 1853-5, 2003 Aug 15.

Article in English | MEDLINE | ID: mdl-12891073

ABSTRACT

A cohort of 297 HIV-infected pregnant women was followed from January 1996 to December 2001. The overall transmission rate was 3.57% and remained constant over time. Low birth-weight was independently associated with a higher risk of vertical transmission (P=0.0072), whereas a longer duration of antiretroviral drugs during pregnancy was independently associated with a lower risk of transmission (P=0.0084). Further decreases in transmission should be obtained by initiating prophylaxis earlier in pregnancy.

Subject(s)

Developing Countries , HIV Infections/transmission , Pregnancy Complications, Infectious , Antiretroviral Therapy, Highly Active , Antiviral Agents/therapeutic use , Brazil/epidemiology , Cohort Studies , Female , HIV Infections/drug therapy , Humans , Infant, Low Birth Weight , Infant, Newborn , Infectious Disease Transmission, Vertical , Lamivudine/therapeutic use , Logistic Models , Pregnancy , Pregnancy Complications, Infectious/drug therapy , Risk Factors , Zidovudine/therapeutic use

ABSTRACT

Subject(s)

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