Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Cell Immunol ; 280(2): 171-81, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23399844

ABSTRACT

Oral tolerance is defined as an inhibition of specific immune responsiveness to a previously ingested antigen. Paradoxically, we found an increased lymphocyte activity in tolerant mice alongside the specific inhibition. Orally-tolerant mice presented higher number of immunoglobulin secreting cells (ISC) in spleen and bone marrow; showed a greater variety of Ig classes being produced: IgM and IgA in the spleen and IgG and IgM in the bone marrow. ISC from immunized mice produced mainly IgG. Despite having the same number of regulatory and activated T cells in the spleen after immunization, these cells appeared earlier in tolerant mice, right after the primary immunization. Also, tolerant mice showed a prompt expression of regulatory cytokines (TGF-ß and IL-10) and a transient expression of effector cytokines (IL-2 and IFN-γ). Thus, in addition to an inhibited specific responsiveness, orally-tolerant mice displayed an early and widespread mobilization of activated and regulatory lymphocytes.


Subject(s)
Immune Tolerance , Lymphocyte Activation , Lymphocytes/immunology , Animals , Antibody-Producing Cells/immunology , Cytokines/biosynthesis , Female , Immunization , Immunoglobulin A/blood , Immunoglobulin M/blood , Mice , Mice, Inbred C57BL , Ovalbumin/immunology
SELECTION OF CITATIONS
SEARCH DETAIL
...