ABSTRACT
The result of vitamin E treatment in 19 uremic patients in chronic hemodialysis is evaluated. In particular, the levels of erythrocyte malonyldialdehyde (MDA) and vitamin E were determined, and the fatty acid composition of red blood cell (RBC) membrane before and after treatment with parenterally administered vitamin E. A decrease of RBC MDA levels, an increase of RBC vitamin E concentrations, and a decreased saturated fatty acid to unsaturated fatty acid ratio were found after treatment with vitamin E. There was a statistically significant increase of the packed RBC volume.
Subject(s)
Lipid Peroxides/biosynthesis , Uremia/blood , Vitamin E/analogs & derivatives , alpha-Tocopherol/analogs & derivatives , Adolescent , Adult , Aged , Child , Erythrocytes/drug effects , Erythrocytes/metabolism , Female , Humans , Male , Malondialdehyde/biosynthesis , Membrane Lipids/metabolism , Middle Aged , Renal Dialysis , Tocopherols , Uremia/drug therapy , Vitamin E/biosynthesis , Vitamin E/therapeutic useSubject(s)
Intestinal Absorption , Thalassemia/metabolism , Vitamin E/metabolism , Child , Child, Preschool , Female , Homozygote , Humans , Male , Thalassemia/geneticsABSTRACT
Some metabolic alterations of the pentose-phosphate shunt can increase susceptibility to red blood cell (RBC) lipid peroxidation in uraemic patients on maintenance haemodialysis. We investigated this phenomenon in 19 uraemic patients undergoing chronic haemodialysis by determining RBC malonyldialdehyde (MDA), a secondary product of lipid peroxidation and plasma and RBC tocopherols, which are powerful antioxidants. Evidence of RBC membrane lipid peroxidation was demonstrated by an increase of RBC MDA. RBC tocopherols were significantly decreased because of enhanced antioxidant activity. No significant variations of these parameters were found before and after dialysis.
