Projections of human papillomavirus vaccination and its impact on cervical cancer using the Caputo fractional derivative.

We propose a fractional order model for human papillomavirus (HPV) dynamics, including the effects of vaccination and public health education on developing cervical cancer. First, we discuss the general structure of Caputo fractional derivatives and integrals. Next, we define the fractional HPV model using Caputo derivatives. The model equilibrium quantities, with their stability, are discussed based on the magnitude of the reproduction number. We compute and simulate numerical solutions of the presented fractional model using the Adams-Bashforth-Moulton scheme. Meanwhile, real data sourced from reports from the World Health Organization is used to establish the parameters and compute the basic reproduction number. We present figures of state variables for different fractional orders and the classical integer order. The impacts of vaccination and public health education are discussed through numerical simulations. From the results, we observe that an increase in both vaccination rates and public health education increases the quality of life, and thus, reduces disease burden and suffering in communities. The results also confirm that modeling HPV transmission dynamics using fractional derivatives includes history effects in the model, making the model further insightful and appropriate for studying HPV dynamics.

Modeling the impact of public health education on tungiasis dynamics with saturated treatment: Insight through the Caputo fractional derivative.

Public health education is pivotal in the management and control of infectious and non-infectious diseases. This manuscript presents and analyses a nonlinear fractional model of tungiasis dynamics with the impact of public health education for the first time. The human population is split into five classes depending on their disease status. The infected population is split into two subgroups; infected but unaware and infected but aware. The model focuses on the impacts of public health education, contact and treatment contact on tungiasis transmission dynamics. Notably, public health education is important for containing as well as reducing disease outbreaks in communities. The Caputo fractional derivative is utilised in defining the model governing equations. Model equilibrium points existence and stability are investigated using simple matrix algebra. Model analysis shows that tungiasis is contained when the reproduction number is less than unity. Otherwise, if it is greater than unity, the disease persists and spread in the population. The generalised Adams-Bashforth-Moulton approach is utilised in solving the derived tungiasis model numerically. The impacts of public health education, treatment and contact rate on overall disease dynamics are discussed through numerical simulations. From the simulations, we see that for given fractional order, public health education and treatment increase the quality of life plus reduce equilibrium numbers of tungiasis-infected individuals. We observe that population classes converge quicker to their steady states when α is increased. Thus, we can conclude that the derivative order α captures the role of experience or knowledge that individuals have on the disease's history.

Mathematical analysis of a lymphatic filariasis model with quarantine and treatment.

BACKGROUND: Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts. METHODS: A mathematical model of lymphatic filariaris with intervention strategies is developed and analyzed. Control of infections is analyzed within the model through medical treatment of infected-acute individuals and quarantine of infected-chronic individuals. RESULTS: We derive the effective reproduction number, [Formula: see text] and its interpretation/investigation suggests that treatment contributes to a reduction in lymphatic filariasis cases faster than quarantine. However, this reduction is greater when the two intervention approaches are applied concurrently. CONCLUSIONS: Numerical simulations are carried out to monitor the dynamics of the filariasis model sub-populations for various parameter values of the associated reproduction threshold. Lastly, sensitivity analysis on key parameters that drive the disease dynamics is performed in order to identify their relative importance on the disease transmission.