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Eksp Klin Farmakol ; 79(4): 26-28, 2016 Aug.
Article in English, Russian | MEDLINE | ID: mdl-29949700

ABSTRACT

We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-ß-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(ß-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-ß-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Edema/drug therapy , Hydroxybenzoates/pharmacology , Plantar Plate/drug effects , Animals , Aspirin/pharmacology , Carrageenan/administration & dosage , Drug Administration Schedule , Edema/chemically induced , Edema/pathology , Female , Hindlimb , Intubation, Gastrointestinal , Plantar Plate/pathology , Plethysmography , Rats , Rats, Wistar
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