ABSTRACT
We describe a fibrosarcoma in a 12-year-old Quarterhorse x Arabian gelding as a sequela to equine influenza vaccination. Shortly after the second vaccination, swelling at the site was noticed by the owner and it continued to increase in size over the following 6 months. Biopsy of the mass indicated a fibrosarcoma had developed at the vaccination site. It was approximately 20 cm in diameter and elevated well above the level of the skin. There was no clinical evidence of metastases to the lungs or local lymph nodes. Surgical resection of the mass was performed and the wound healed by first and second intention. Histopathological examination and immunohistochemical staining confirmed a myofibroblastic fibrosarcoma with multifocal osseous metaplasia. To the authors' knowledge, this is the first equine case of a vaccine-associated fibrosarcoma.
Subject(s)
Fibrosarcoma/veterinary , Horse Diseases/chemically induced , Influenza Vaccines/adverse effects , Neoplasms, Muscle Tissue/veterinary , Soft Tissue Neoplasms/veterinary , Animals , Fibrosarcoma/chemically induced , Fibrosarcoma/surgery , Horse Diseases/surgery , Horses , Male , Neoplasms, Muscle Tissue/chemically induced , Neoplasms, Muscle Tissue/surgery , Soft Tissue Neoplasms/chemically induced , Soft Tissue Neoplasms/surgery , Treatment Outcome , Vaccination/adverse effects , Vaccination/veterinaryABSTRACT
Cutaneous squamous cell carcinomas may cause death by metastasis or by local extension. We describe a deeply invasive cutaneous squamous cell carcinoma that caused death by direct extension into the brain.
Subject(s)
Brain Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Maxillary Sinus Neoplasms/pathology , Orbital Neoplasms/pathology , Skin Neoplasms/pathology , Aged , Fatal Outcome , Humans , Male , Neoplasm InvasivenessABSTRACT
A series of 109 patients was divided according to type of palatal defect, technique of repair (pushback, von Langenbeck, or pushback with island flap), results of standardized multifactorial speech analyses, and effectiveness of primary and secondary operations. Sixty-five patients (60 percent) showed improved speech after the initial repair, with 49 of these rated as "good." Forty-five percent improved after the von Langenbeck operation, 57 percent improved after the pushback procedure, and 53 percent improved after the pushback/island flap repair. Persistent hypernasal speech was treated with superiorly based pharyngeal flaps in 18 patients with uniform success (p less than or equal to 0.001). The worst results (after all three techniques) followed the repair of bilateral complete clefts. This experience has tempered our expectations in dealing with cleft palate patients, especially those having bilateral defects.
Subject(s)
Cleft Palate/surgery , Child, Preschool , Follow-Up Studies , Humans , Infant , Pharynx/surgery , Prognosis , Surgical FlapsABSTRACT
The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
