ABSTRACT
INTRODUCTION: Hydroxyapatite based drug carriers offer a customized alternative to the delivery of pharmacologic agents in the osseous skeleton. They have an added advantage of being biocompatible and osteoconductive. This in vitro study aims to quantify the drug eluting properties of HA granules by spectrophotometry. MATERIALS AND METHODS: HA and HASi beads were loaded with gentamicin/ amoxycillin- clavulanate/ vancomycin and grouped into 5. Drug elution was evaluated by means of UV spectrophotometry. RESULTS: Drug eluent levels were well above bactericidal levels in all 5 groups. CONCLUSION: HA and HASi are viable options for clinicians for targeted drug delivery.
Subject(s)
Durapatite , Vancomycin , Anti-Bacterial Agents , Biocompatible Materials , Bone Regeneration , Drug Carriers , GentamicinsABSTRACT
BACKGROUND: Bioceramics and their composites have found myriad applications in medicine as superlative osteoalloplasts. Their potential to function as a biocompatible resorbable drug delivery system is being explored. The present study is a preliminary investigation into the efficacy of these indigenously developed nanoporous materials as vehicles for therapeutic agents. An in vitro experiment was conducted with the goal of assessing this material and comparing it with a commercially available gentamicin-loaded polymethylmethacrylate cement. STUDY DESIGN: The drug-eluting characteristics of gentamicin bone cement and indigenously designed nanoporous bioceramic granules were analyzed spectrophotometrically and compared. Regression analysis was done. RESULTS: The first 5 days saw the elute from both samples containing drug concentrations >100 µg/g. CONCLUSIONS: Both samples exhibit a high initial-burst release, which is ideal for prophylactic purposes. Drug eluent levels for both materials were >100 µg/g, which is sufficient for bactericidal activity.
Subject(s)
Biocompatible Materials/chemistry , Ceramics/chemistry , Drug Delivery Systems , Nanostructures/chemistry , Absorbable Implants , Biocompatible Materials/chemical synthesis , Bone Cements/chemistry , Ceramics/chemical synthesis , Delayed-Action Preparations , Diffusion , Durapatite/chemistry , Gentamicins/administration & dosage , Humans , Materials Testing , Microspheres , Polymethyl Methacrylate/chemistry , Polyvinyl Alcohol/chemistry , Porosity , Spectrophotometry , Surface Properties , ViscosityABSTRACT
Aneurysms of the superficial temporal artery are relatively rare vascular complications following trauma. Two cases of pseudoaneurysm of the anterior branch of the superficial temporal artery, subjected to blunt maxillofacial trauma are presented here. The first case was treated by surgical resection and the second was cured by application of continuous pressure. The review of the English literature has also been included. An awareness of these vascular injuries, despite their infrequency, is necessary to facilitate early diagnosis, proper investigation and prompt treatment.
ABSTRACT
Platelet-rich plasma (PRP), the concentrate of platelets in plasma contains various growth factors that enhance osseous regeneration. This study utilized homologous platelet-rich plasma in the treatment of third molar extraction sockets in a total of fourteen human subjects, who were randomly assigned into one control and one test group, each comprising of seven members. Clinical parameters like pain on palpation, number of analgesic tablets consumed, swelling, degree of mouth opening, and condition of mucosa overlying the surgical site were assessed at intervals of 1,3,5,7,9,12, and 16 weeks post operatively. The margins between the socket and surrounding bone, radiopacity of bone filling the socket, and presence oftrabecular bone formation were evaluated simultaneously. Soft tissue healing differed significantly between the two groups, with the test group exhibiting better results. Radiographic evidence of bone formation was visible as early as I week in test subjects. It was concluded that PRP contributed to better healing of soft tissues and bone and is a viable means of growth factor delivery.
Subject(s)
Blood Platelets/physiology , Bone Regeneration/physiology , Molar, Third/surgery , Tooth Socket/physiopathology , Adult , Alveolar Process/diagnostic imaging , Alveolar Process/pathology , Analgesics/therapeutic use , Edema/etiology , Female , Follow-Up Studies , Gingiva/pathology , Gingiva/physiopathology , Humans , Male , Mandible/physiopathology , Movement , Pain, Postoperative/etiology , Plasma , Radiography , Tooth Extraction , Tooth Socket/diagnostic imaging , Tooth Socket/pathology , Tooth, Impacted/surgery , Wound Healing/physiologyABSTRACT
BACKGROUND: Primary central mucoepidermoid carcinoma of jaws is a rare lesion comprising 2-3% of all mucoepidermoid carcinomas reported in literature. CASE PRESENTATION: The case presented here illustrates the hypothesis that its specific pathogenesis is unknown. CONCLUSIONS: Mucoepidermoid carcinoma of the jaw is a rare tumour of unknown aetiology. Although about a 100 cases has been reported in literature, the speculation on its aetiopathogenesis has mainly centred on the pluripotential capabilities of the epithelial lining of odontogenic cysts.
