Characterization of a multi-axis ion chamber array.

PURPOSE: The aim of this work was to characterize a multi-axis ion chamber array (IC PROFILER; Sun Nuclear Corporation, Melbourne, FL, USA) that has the potential to simplify the acquisition of LINAC beam data. METHODS: The IC PROFILER (or panel) measurement response was characterized with respect to radiation beam properties, including dose, dose per pulse, pulse rate frequency (PRF), and energy. Panel properties were also studied, including detector-calibration stability, power-on time, backscatter dependence, and the panel's agreement with water tank measurements [profiles, fractional depth dose (FDD), and output factors]. RESULTS: The panel's relative deviation was typically within (+/-) 1% of an independent (or nominal) response for all properties that were tested. Notable results were (a) a detectable relative field shape change of approximately 1% with linear accelerator PRF changes; (b) a large range in backscatter thickness had a minimal effect on the measured dose distribution (typically less than 1%); (c) the error spread in profile comparison between the panel and scanning water tank (Blue Phantom, CC13; IBA Schwarzenbruck, DE) was approximately (+/-) 0.75%. CONCLUSIONS: The ability of the panel to accurately reproduce water tank profiles, FDDs, and output factors is an indication of its abilities as a dosimetry system. The benefits of using the panel versus a scanning water tank are less setup time and less error susceptibility. The same measurements (including device setup and breakdown) for both systems took 180 min with the water tank versus 30 min with the panel. The time-savings increase as the measurement load is increased.

Wide field array calibration dependence on the stability of measured dose distributions.

PURPOSE: The aim of this work was to simulate the effect of dose distribution changes on detector array calibrations and to explore compensatory methods that are used during calibration measurements. METHODS: The array calibration technique that was investigated is known as wide field (WF) calibration. Using this method, a linear array [y-axis (65 detectors) of the IC PROFILER (Sun Nuclear Corporation, Melbourne, FL)] is calibrated with three measurements (alpha, theta, and lamda); each measurement uses the same radiation field, which is larger than the array. For measurement configuration theta, the array is rotated by 180 degrees from its position in a; for lamda, the array is shifted by one detector from its position in theta. The relative detector sensitivities are then determined through ratios of detector readings at the same field locations (using theta and lamda). This method results in error propagation that is proportional to the number of detectors in the array. During the procedure, the calibration protocol operates under three postulates, which state that (a) the beam shape does not change between measurements; (b) the relative sensitivities of the detectors do not change; and (c) the scatter to the array does not change as the array is moved. The WF calibration's sensitivity to a postulate (a) violation was quantified by applying a sine shaped perturbation (of up to 0.1%) to a, theta, or lamda, and then determining the change relative to a baseline calibration. Postulate (a) violations were minimized by using a continuous beam and mechanized array movement during theta and lamda. A continuously on beam demonstrated more stable beam symmetry as compared to cycling the beam on and off between measurements. Additional side-scatter was also used to satisfy postulate (c). RESULTS: Simulated symmetry perturbations of 0.1% to theta or lamda resulted in calibration errors of up to 2%; alpha was relatively immune to perturbation (<0.1% error). Wide field calibration error on a linear accelerator with similar symmetry variations was +/- 1.6%. Using a continuous beam during theta and lamda with additional side-scatter reduced the calibration error from +/- 1.6% to +/- 0.48%. CONCLUSIONS: This work increased the reproducibility of WF calibrations by limiting the effect of measurement perturbations primarily due to linear accelerator symmetry variations. The same technique would work for any array using WF calibration.

An MLC calibration method using a detector array.

PURPOSE: The authors have developed a quantitative calibration method for a multileaf collimator (MLC) which measures individual leaf positions relative to the MLC backup jaw on an Elekta Synergy linear accelerator. METHODS: The method utilizes a commercially available two-axis detector array (Profiler 2; Sun Nuclear Corporation, Melbourne, FL). To calibrate the MLC bank, its backup jaw is positioned at the central axis and the opposing jaw is retracted to create a half-beam configuration. The position of the backup jaws field edge is then measured with the array to obtain what is termed the radiation defined reference line. The positions of the individual leaf ends relative to this reference line are then inferred by the detector response in the leaf end penumbra. Iteratively adjusting and remeasuring the leaf end positions to within specifications completes the calibration. Using the backup jaw as a reference for the leaf end positions is based on three assumptions: (1) The leading edge of an MLC leaf bank is parallel to its backup jaw's leading edge, (2) the backup jaw position is reproducible, and (3) the measured radiation field edge created by each leaf end is representative of that leaf's position. Data from an electronic portal imaging device (EPID) were used in a similar analysis to check the results obtained with the array. RESULTS: The relative leaf end positions measured with the array differed from those measured with the EPID by an average of 0.11+/-0.09 mm per leaf. The maximum leaf positional change measured with the Profiler 2 over a 3 month period was 0.51 mm. A leaf positional accuracy of +/-0.4 mm is easily attainable through the iterative calibration process. The method requires an average of 40 min to measure both leaf banks. CONCLUSIONS: This work demonstrates that the Profiler 2 is an effective tool for efficient and quantitative MLC quality assurance and calibration.

On the sensitivity of patient-specific IMRT QA to MLC positioning errors.

Accurate multileaf collimator (MLC) leaf positioning plays an essential role in the effective implementation of intensity modulated radiation therapy (IMRT). This work evaluates the sensitivity of current patient-specific IMRT quality assurance (QA) procedures to minor MLC leaf positioning errors. Random errors of up to 2 mm and systematic errors of +/-1 mm and +/-2 mm in MLC leaf positions were introduced into 8 clinical IMRT patient plans (totaling 53 fields). Planar dose distributions calculated with modified plans were compared to dose distributions measured with both radiochromic films and a diode matrix. The agreement between calculation and measurement was evaluated using both absolute distance-to-agreement (DTA) analysis and gamma index with 2%/2 mm and 3%/3 mm criteria. It was found that both the radiochromic film and the diode matrix could only detect systematic errors on the order of 2 mm or above. The diode array had larger sensitivity than film due to its excellent detector response (such as small variation, linear response, etc.). No difference was found between DTA analysis and gamma index in terms of the sensitivity to MLC positioning errors. Higher sensitivity was observed with 2%/2 mm than with 3%/3 mm in general. When using the diode array and 2%/2 mm criterion, the IMRT QA procedure showed strongest sensitivity to MLC position errors and, at the same time, achieved clinically acceptable passing rates. More accurate dose calculation and measurement would further enhance the sensitivity of patient-specific IMRT QA to MLC positioning errors. However, considering the significant dosimetric effect such MLC errors could cause, patient-specific IMRT QA should be combined with a periodic MLC QA program in order to guarantee the accuracy of IMRT delivery.

Multileaf collimator characteristics and reliability requirements for IMRT Elekta system.

Understanding the characteristics of a multileaf collimator (MLC) system, modeling MLC in a treatment planning system, and maintaining the mechanical accuracy of the linear accelerator gantry head system are important factors in the safe implementation of an intensity-modulated radiotherapy program. We review the characteristics of an Elekta MLC system, discuss the necessary MLC modeling parameters for a treatment planning system, and provide a novel method to establish an MLC leaf position quality assurance program. To perform quality assurance on 40 pairs of individual MLC leaves is a time-consuming and difficult task. In this report, an effective routine MLC quality assurance method based on the field edge of a backup jaw as referenced in conjunction with a diode array as a radiation detector system is discussed. The sensitivity of this test for determining the relative leaf positions was observed to be better than 0.1 mm. The Elekta MLC leaf position accuracy measured with this system has been better than 0.3 mm.

Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice.

Prader-Willi syndrome (PWS), most notably characterized by infantile hypotonia, short stature and morbid obesity, results from deficiencies in multiple genes that are subject to genomic imprinting. The usefulness of current mouse models of PWS has been limited by postnatal lethality in affected mice. Here, we report the survival of the PWS-imprinting center (IC) deletion mice on a variety of strain backgrounds. Expression analyses of the genes affected in the PWS region suggest that while there is low-level expression from both parental alleles in PWS-IC deletion pups, this expression does not explain their survival on certain strain backgrounds. Rather, the data provide evidence for strain-specific modifier genes that support the survival of PWS-IC deletion mice.