Dissociation As a Mechanism of Risk for Interpersonal Victimization Among Adolescent Girls.

Childhood interpersonal violence exposure (IVE) is associated with repeated victimization in adolescence and adulthood. Research suggests dissociation, a psychological phenomenon characterized by alterations and disruptions to consciousness, memory, and perceptions of the environment, and out-of-body experiences, increases the risk of revictimization. Self-report data from a longitudinal study of 92 violence-exposed adolescent girls from a large, urban area were analyzed to assess whether dissociation predicts polyvictimization or exposure to multiple types of interpersonal violence across adolescence. Participants' mental and interpersonal health was assessed at four in-person laboratory visits scheduled across 3.5 years (i.e., T1-T4). IVE included direct or indirect victimization experienced at home, school, the neighborhood, or town, such as child maltreatment, domestic violence, peer victimization, dating aggression, and community violence. Polyvictimization was operationalized as a composite score of the different types of IVE endorsed by the participant or caregiver. A random-intercept cross-lagged panel model was used to test the bidirectional relationships between dissociation and polyvictimization longitudinally. Cross-lagged regressions were analyzed to determine whether dissociation and polyvictimization predicted subsequent dissociation symptoms and polyvictimization. Concurrent and previous dissociation significantly accounted for polyvictimization at T2, T3, and T4. Polyvictimization did not significantly predict future dissociation symptoms. The results from this study provide support for dissociation's unique contribution to polyvictimization among violence-exposed girls, making it an important target for clinical assessment and treatment.

Development of a Binderless Particleboard from Brown Seaweed Sargassum spp.

Since 2010, huge quantities of Sargassum spp. algae have been proliferating in the Atlantic Ocean and stranding on Caribbean beaches, causing major economic, environmental, and health problems. In this study, an innovative high-density binderless particleboard was developed using uniaxial thermo-compression coupled with a cooling system. The raw material consisted of ground Sargassum seaweeds pre-treated by twin-screw extrusion with water to remove sea salt. The raw material and the particleboards were produced by using various analytical techniques such as Dynamic Vapor Sorption (DVS), Differential Scanning Calorimetry (DSC), Dynamic Mechanical Analysis (DMA), or Thermogravimetric Analysis (TGA). The experimental conditions for thermo-compression (temperature, pressure, time) were evaluated. The best thermo-compression conditions tested were 200 °C, 40 MPa pressure for 7.5 min. This resulted in a particleboard with high density (up to 1.63 ± 0.02 g/cm3) and high flexural strength/modulus (up to 32.3 ± 1.8 MPa/6.8 ± 0.2 GPa, respectively), but a low water contact angle of 38.9° ± 3.5°. Thermal analyses revealed the effect of alginates on the mechanical properties of particleboards. This work opens the door to a new way of adding value to Sargassum seaweed, using the whole algae with minimal pre-treatment.

Psychometric Properties of the Sexual Subjectivity Inventory among Lesbian, Gay, and Bisexual Emerging Adults.

Research highlights the significance of positive sexual self-perceptions for general and sexual health. Yet, most research on the sexuality of lesbian, gay, and bisexual (LGB) individuals has been risk-oriented, leaving a critical gap in knowledge about normative and healthy sexuality among sexual minorities. In part, this gap is due to a lack of sexual health measures with established psychometric properties for LGB individuals. The current study examined the factor structure, reliability, factorial invariance, and validity of the Sexual Subjectivity Inventory (SSI) in a sample of 746 lesbian (n = 123), gay (n = 204), and bisexual (n females = 234; n males = 185) emerging adults (Mage = 23.4 years). Factor analyses revealed the same five-factor structure found in similar aged heterosexual samples and strict factorial invariance by sexual and cisgender identities. Factor scores were internally consistent and associated with indicators of sexual well-being (i.e., safe sex self-efficacy, internalized homonegativity) and general well-being (life satisfaction, identity achievement) in theoretically meaningful ways. Sexual subjectivity was largely unrelated to health risk behavior. Results support the use of the SSI with LGB emerging adults for advancing holistic perspectives on LGB sexuality.

Microchamber Extraction and Analytical Pyrolysis to Explore Volatile Organic Compounds from Compression-Cooking Wood Materials Obtained under Different Conditions.

Volatile organic compounds are species of concern for indoor air quality. They are emitted from a wide range of indoor sources and in particular from construction materials. Industrialized wood-based panels made from various types of wood bonded with thermosetting adhesive resins have been shown to emit volatile organic compounds over months or even years mostly due to the petrochemical binders. Some studies have been conducted on binderless panels, but they mainly focused on the pressing parameters to be applied to optimize the panel characteristics. The aim of this research is to document the emissions from binderless panels and to access the volatile composition of wood processing through the molding of materials. For this purpose, binderless boards were manufactured from hardwoods, known to emit less than softwoods with different thermopressing temperatures and times. Emissions were studied by placing the materials in microchambers. Volatile organic compounds were then sampled and analyzed by various chromatographic methods. On the other hand, materials were pyrolyzed and then analyzed by gas chromatography and mass spectrometry. The implemented protocols proved suitable for the determination of more than 40 organic compounds, among which are aldehydes, aromatics, furans and derivatives, and carboxylic acids.

Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer.

The PEAK family pseudokinases are essential components of tyrosine kinase (TK) pathways that regulate cell growth and adhesion; however, their role in human cancer remains unclear. Here, we report an oncogenic activity of the pseudokinase PEAK2 in colorectal cancer (CRC). Notably, high PRAG1 expression, which encodes PEAK2, was associated with a bad prognosis in CRC patients. Functionally, PEAK2 depletion reduced CRC cell growth and invasion in vitro, while its overexpression increased these transforming effects. PEAK2 depletion also reduced CRC development in nude mice. Mechanistically, PEAK2 expression induced cellular protein tyrosine phosphorylation, despite its catalytic inactivity. Phosphoproteomic analysis identified regulators of cell adhesion and F-actin dynamics as PEAK2 targets. Additionally, PEAK2 was identified as a novel ABL TK activator. In line with this, PEAK2 expression localized at focal adhesions of CRC cells and induced ABL-dependent formation of actin-rich plasma membrane protrusions filopodia that function to drive cell invasion. Interestingly, all these PEAK2 transforming activities were regulated by its main phosphorylation site, Tyr413, which implicates the SRC oncogene. Thus, our results uncover a protumoural function of PEAK2 in CRC and suggest that its deregulation affects adhesive properties of CRC cells to enable cancer progression.

A novel approach to discriminate the volatilome of Vitis vinifera berries by selected ion flow tube mass Spectrometry analysis and chemometrics.

This study investigated a quick way to discriminate grape varieties based on their composition in volatile compounds through a SIFT-MS scan coupled with simple chemometrics approaches such as analysis of variance (ANOVA), principal component analysis (PCA) and hierarchical ascendant classification (HAC). The 23 studied grape varieties were distinguishable using O2+, H3O+ and NO+ as reagent ions, and the combination of these three ions. For its ability to ionize most compounds, to efficiently fragment them to generate ions with distinct m/z ratio, and to enhance the differentiation of compounds of similar masses, O2+ reagent ion should be preferentially considered. The use of one single ion rather than three enables to limit the time of analysis and the number of variables to be treated. The technique allowed the distinction of high and low aroma compounds producers as confirmed by headspace solid-phase microextraction followed by gas chromatography-mass spectrometry (HS-SPME/GC-MS) analyses. SIFT-MS is a quick and interesting tool with potential application in various fields of viticulture such as phenotyping of grape varieties or non-targeted studies on the impact of environmental factors or viticultural practices on grape aroma composition.

Regulation of Src tumor activity by its N-terminal intrinsically disordered region.

The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal intrinsically disordered unique domain (UD) whose function remains unclear. Using NMR, we reported that UD forms an intramolecular fuzzy complex involving a conserved region with lipid-binding capacity named Unique Lipid-Binding Region (ULBR), which could modulate Src membrane anchoring. Here we show that the ULBR is essential for Src's oncogenic capacity. ULBR inactive mutations inhibited Src transforming activity in NIH3T3 cells and in human colon cancer cells. It also reduced Src-induced tumor development in nude mice. An intact ULBR was required for MAPK signaling without affecting Src kinase activity nor sub-cellular localization. Phospho-proteomic analyses revealed that, while not impacting on the global tyrosine phospho-proteome in colon cancer cells, this region modulates phosphorylation of specific membrane-localized tyrosine kinases needed for Src oncogenic signaling, including EPHA2 and Fyn. Collectively, this study reveals an important role of this intrinsically disordered region in malignant cell transformation and suggests a novel layer of Src regulation by this unique region via membrane substrate phosphorylation.

When data drive health: an archaeology of medical records technology.

Medicine is often thought of as a science of the body, but it is also a science of data. In some contexts, it can even be asserted that data drive health. This article focuses on a key piece of data technology central to contemporary practices of medicine: the medical record. By situating the medical record in the perspective of its history, we inquire into how the kinds of data that are kept at sites of clinical encounter often depend on informational requirements that originate well outside of the clinic, in particular in health insurance records systems. Although this dependency of today's electronic medical records on billing requirements is widely lamented by clinical providers, its history remains little studied. Following the archaeology of medicine developed by Michel Foucault in The Birth of the Clinic and expanding his methodology in light of more recent contributions to the field of media archaeology, this article excavates some of the underexplored technological conditions that help constitute today's electronic medical record. If in some contexts, it is true that data drive health, then an archaeology of medical records helps reveal how health insurance records often impact clinical care and, by extension, health and disease.

Empowerment Through Participation in a Cancer Prevention Exhibit: Evidence from the Hygée Lab Intervention.

While many countries have launched cancer prevention initiatives to improve the public's understanding of risk and protective factors, few are systematically evaluated. Hygée Lab, a living lab in a socioeconomically deprived area of France, is designed to interactively communicate evidence-based information about cancer prevention and treatment with the goal to improve visitors' understanding of cancer risk and prevention factors, reduce fatalism in regard to cancer, and increase feelings of empowerment. Pre- and post-visit data were collected during the first 18 months of the exhibit's opening from two segments of the population: adolescents from local schools (N = 134) and the general public (N = 112). Adolescents from the same schools who did not participate in the visit comprised the control group (N = 94). A further 232 general public visitors completed post-surveys only. Pre-post-visit comparisons reveal significant changes in both adolescent and general public visitors: cancer understanding improves, fatalism in regard to cancer is reduced, and feelings of empowerment increase. This systematic evaluation of Hygée Lab offers promise for how interactive exhibits may be used for cancer prevention amongst low health literacy populations.

Identification of Potential Extractablesand Leachables in Cosmetic Plastic Packagingby Microchambers-Thermal Extraction and Pyrolysis-Gas Chromatography-Mass Spectrometry.

Most container-content interaction studies are carried out through migration tests on end products or simulants involving generally toxic solvents. This study was conducted with the aim of identifying potential leachables from materials used in cosmetic plastic packaging by using two approaches based on solvent-free extraction, i.e., solid-phase microextraction sampling and pyrolyzer/thermal desorption coupled with gas chromatography mass spectrometry. Volatile and semi-volatile intentionally and non-intentionally added substances were detected in seven packaging samples made of polypropylene, polyethylene, and styrene-acrylonitrile copolymer. Thirty-five compounds related to the polymers industry or packaging industry were identified, among them phthalates, alkanes, styrene, and cyanide derivates including degradation products, impurities, additives, plasticizers, and monomers. All except eight belong to the Cramer class I. These thermodesorption techniques are complementary to those used for migration tests.

Development of a HS-SPME-GC-MS method for the analysis of phthalates in glycerin and liquid paraffin: application to safety evaluation of cosmetic packagings.

Migration of molecules from packaging into products is a well-known phenomenon of which the studies in the food and medical industries are regulated in Europe by several legislations. However, for cosmetic packagings, there is no protocol nor specific migration limits available. The objective of this work was to use glycerin and liquid paraffin as cosmetic product simulants to perform a safety assessment on phthalates in 11 plastic packagings used in the cosmetic industry. To study these compounds in the matrices, 2 extraction techniques were compared: liquid-liquid extraction and solid-phase microextraction (SPME). The optimization of the 2 processes of extraction showed that SPME was more adapted to the study. Finally, samples of glycerin and liquid paraffin were analyzed by a SPME-GC-MS method to quantitate 10 regulated phthalates. In glycerin, only DEP was quantitated above the LOQ in 3 packagings, but the concentrations measured were under the set concentration threshold of 0.5 ppm. In liquid paraffin, DEP was quantitated above this concentration threshold. A safety evaluation was so performed by calculating the systemic exposure damage, and the results were finally considered to be safe for consumers.

VOC and carbonyl compound emissions of a fiberboard resulting from a coriander biorefinery: comparison with two commercial wood-based building materials.

Indoor air quality is a major public health issue. It is related to the choice of construction materials and associated with VOC emissions. Two wood-based commercial panels were tested: a medium-density fiberboard (MDF) and a chipboard (CH), and they were compared to a material produced from a coriander biorefinery (COR). Indicators chosen to compare the materials were physical properties (density, bending properties, surface hardness, thickness swelling, and water absorption) and VOC emissions. Emissions were evaluated in an environmental chamber at 23 °C, 31 °C, and 36 °C, and during 28 days. Carbonyl emissions on day 1 at 23 °C were 74, 146, and 35 µg m-2 h-1, respectively, for MDF, CH, and COR. Terpenic emissions were 12, 185, and 37 µg m-2 h-1, respectively. Higher temperature resulted in higher emissions which decreased over time, except for formaldehyde. VOC emissions depended largely on material and temperature. Formaldehyde emission was 300 to 600 times lower for coriander boards (< 0.2 µg m-2 h-1), making them significantly more environmentally friendly materials in comparison with MDF and chipboard. These results highlight the interest of coriander by-products as raw materials for producing fiberboards with low impact on indoor air quality.

Caregivers as gatekeepers: Professional mental health service use among urban minority adolescents.

Mental illness among adolescents frequently goes untreated, especially among low income and ethnic minority families. We sought to examine parent and adolescent psychological factors influencing mental health service use among 120 urban adolescents (82% African American, Age 13-18 years, M = 14.29, SD = 1.52) who had access to mental health treatment through their community primary care setting. We utilized structural equation modeling (SEM) to explore the independent and combined associations among parent and adolescent variables hypothesized to be associated with the youth's engagement in mental health treatment. Results showed that more than half (63.6%) of youth with clinically significant levels of symptoms were not currently engaged in treatment or seeking mental health services. One latent variable emerged: caregivers' perceptions of adolescent mental health problems (consisted of youth psychological symptoms, youth functional impairment, and strain on caregiver). Together with caregivers' attitude toward professional help, these two caregiver-reported variables, but not adolescents' attitude, were associated with higher likelihood of service utilization among adolescents. Findings suggest caregivers functioned as the "gatekeepers" to mental health services. We discuss findings' implications for engaging youth in mental health services as well as study limitations and future directions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Romantic Conflict Narratives in Emerging Adult Couples: Viewpoint and Gender Matter.

Healthy romantic relationships entail understanding the needs of the self and other when interpreting conflict events. Yet how couples make meaning around specific conflicts and their capacity to reflect on their own and their partners' unmet needs is understudied. Using narratives, we examined destructive (e.g., extreme anger and break-up anxiety) and constructive (e.g., perspective taking) interpretations of past romantic conflicts in 80 emerging adult heterosexual couples and the extent to which such interpretations varied by viewpoint and gender. Couple members were interviewed separately about two conflict episodes in which their partner did not meet their needs (victim viewpoint) and two episodes in which they did not meet their partners' needs (perpetrator viewpoint). As anticipated, destructive interpretations were more evident in the victim viewpoint and for female couple members. In contrast, within constructive interpretations, the use of insight was greater in the perpetrator than the victim viewpoint. Although perspective taking was expected to be more common in the perpetrator viewpoint and in female narratives, this was not the case, as this type of constructive interpretation was infrequent in narratives about conflict. The findings revealed aspects of meaning making that might be useful to mental health professionals concerned with building skills to improve romantic competence in emerging adult couples.

Las relaciones amorosas saludables implican comprender las necesidades del yo y del otro a la hora de interpretar situaciones de conflicto. Sin embargo, hay pocos estudios sobre la manera en la que las parejas dan sentido a conflictos específicos y su capacidad de reflexionar sobre sus propias necesidades no satisfechas y las de sus parejas. Utilizando relatos, analizamos interpretaciones destructivas (p. ej.: enfado intenso y ansiedad por una separación) y constructivas (p. ej.: adopción de un punto de vista) de conflictos amorosos del pasado en 80 parejas heterosexuales de adultos emergentes y la medida en que dichas interpretaciones variaron según el punto de vista y el género. Se entrevistó por separado a los integrantes de las parejas acerca de dos episodios de conflicto en los cuales su pareja no satisfizo sus necesidades (punto de vista de la víctima) y dos episodios en los cuales ellos no satisficieron las necesidades de sus parejas (punto de vista del perpetrador). Como se anticipó, las interpetaciones destructivas fueron más evidentes en el punto de vista de la víctima y en los integrantes femeninos de la pareja. Por el contrario, dentro de las interpretaciones constructivas, el uso de comprensión fue mayor en el punto de vista del perpetrador que en el de la víctima. Aunque se esperaba que la adopción de perspectivas fuera más común en el punto de vista del perpetrador y en los relatos femeninos, no fue así, ya que este tipo de interpretación constructiva fue infrecuente en los relatos sobre los conflictos. Los resultados revelaron aspectos de la creación de significado que podrían ser útiles para los profesionales de la salud mental interesados en el desarrollo de habilidades orientadas a mejorar la aptitud amorosa en las parejas de adultos emergentes.

A Comparison of Hobbies and Organized Activities Among Low Income Urban Adolescents.

OBJECTIVES: Youths' participation in organized activities has been repeatedly associated with better psychosocial adjustment. However, youth living in more disadvantaged contexts (e.g., lower-income, dangerous neighborhoods) have less access to organized activities. The current study aimed to compare hobbies and organized activities, in terms of their accessibility and associations with social functioning with peers, using a social ecological framework. We also examined the conditional effects of family and neighborhood disadvantage for the associations between activity engagement and peer functioning. METHODS: Participants were 91 predominantly African American, urban-dwelling middle school girls (Mage = 12.43) and their primary caregivers. Dyads completed separate interviews and questionnaires on activity engagement, family and neighborhood disadvantage, and social functioning with peers. RESULTS: Results suggest that hobbies are a distinct facet of activity engagement that might be more widely accessible than organized activities. Greater involvement in hobbies and organized activities showed unique associations with indices of better peer functioning. Moreover, some of these associations were stronger for youth living in more disadvantaged contexts. CONCLUSIONS: This study advances the understanding of an important yet neglected topic within the adolescent development literature on activity research, namely differential access to opportunities among ethnic minority youth. Results suggest that hobby engagement is an important aspect of activity engagement with social benefits, especially for youth living in more disadvantaged contexts. Further investigation is warranted to understand the range of potential benefits of youths' hobby involvement.

Ozone Quantification by Selected Ion Flow Tube Mass Spectrometry: Influence of Humidity and Manufacturing Gas of Ozone Generator.

The quantification of ozone by SIFT-MS was investigated in conditions suitable with an industrial emission context (high ozone demand, dry air/oxygen as the manufacturing gas of the ozone generator, and high humidity levels beyond saturation at room conditions). Ozone reacts with four negative precursor ions available in the SIFT-MS device (NO2-, O2-, HO-, and O-), each precursor ion having its specific domain of linearity. For a high ozone concentration range, only NO2- and O2- have resulted in a linear behavior (between 1 and 100 ppmv of O3 for NO2-, between 1 and 50 ppmv of O3 for O2-). No water interference was identified during ozone measurements by SIFT-MS using NO2- and O2- precursor ions, even with extreme humidity levels. The presence of nitrogen oxide contaminants (due to the use of dry air as the manufacturing gas of the ozone generator) affected the ozone quantification by SIFT-MS. It is critical for NO2- precursor ions, whose rate constant varied as a function of NO2 concentrations. With O2- precursor ion, ozone was successfully measured in the presence of nitrogen oxides; however, the secondary chemistry must be taken into account.

Aldehydes gas ozonation monitoring: Interest of SIFT/MS versus GC/FID.

Two analytical techniques - online Gas Chromatography coupled with Flame Ionization Detector (often used method for VOCs monitoring) versus Selected Ion Flow Tube coupled with Mass Spectrometry (a more recent technique based on direct mass spectrometry) - were compared in association to an ozone-based gas treatment. Selecting aldehydes as the representative VOCs, their concentrations were monitored during ozonation experiments by both techniques in parallel. Contradictory results were obtained in the presence of ozone. Aldehydes were up to 90% removed due to a reaction with ozone according to GC/FID analysis, whereas with SIFT/MS, aldehydes concentration remained at the same level during the experiments regardless of the ozone presence. In addition, it was demonstrated that the apparent aldehydes removal was affected by GC injector temperature, varying from 90% (when it was at 250 °C) to 60% (at 100 °C). Meanwhile, even when the ozonation reactor was heated to 100 °C, no aldehydes conversion was evidenced by SIFT/MS, suggesting that the GC injector temperature was not the only interference-causing parameter. The ozone-aldehyde reaction is probably catalyzed by some material of GC injector and/or column. An ozone-GC interference was therefore confirmed, making unsuitable the use of GC/FID with silicone stationary phase to monitor aldehydes in presence of high concentrations of ozone (at least 50 ppmv). On the other hand, SIFT/MS was validated as a reliable technique, which can be employed in order to measure VOCs concentrations in ozonation processes.

Onset Trajectories of Sexting and Other Sexual Behaviors Across High School: A Longitudinal Growth Mixture Modeling Approach.

Sexting is receiving substantial scholarly attention and is now considered commonplace in adolescence. Little is known, however, about the normative contexts and the development of adolescent sexting behavior, including the initiation of sexting in relation to other sexual behaviors. In this study, we used growth mixture modeling to identify classes of onset trajectories for sexual behaviors across high school. Participants included 429 high school students (54% female) who completed annual assessments of sexual behavior over a three-year period. We identified four distinct classes: postponement (9%) with no behaviors other than hand-holding and kissing initiated by Grade 11, gradual onset (44%) with sexting and other sexual behaviors emerging incrementally across high school, continuous onset (32%) with sexting and other sexual behaviors within the first three years of high school, early onset (15%) with initiation of sexting and all other sexual behaviors prior to or by the end of Grade 9. Boys were more likely than girls to be members of the postponement versus gradual onset class, while Black students were more likely than White students to be members of the early versus gradual onset class. Sexting behavior appears to be common in adolescence and co-emerges with genital contact behavior across varying trajectories of sexual development. These findings provide the foundation for contextualizing sexting within normative sexual development. Further, this information can inform efforts to promote sexual health.

Assessment of targeted non-intentionally added substances in cosmetics in contact with plastic packagings. Analytical and toxicological aspects.

Container-content interactions are common in the food and pharmaceutical industries. However, these studies are more complicated in the cosmetic industry, and it is necessary to ensure consumer safety. The objective of this work was to develop a strategy for the toxicological evaluation of leachables for cosmetic packagings. Eleven common plastic packagings were selected to evaluate interactions with 5 simulants (acidic, alkaline and neutral water, 30% and 96% ethanol) chosen to mimic cosmetics behavior. A GC-MS method was developed to screen for 12 non-intentionally added substances of particular concern: 10 phthalates, bisphenol A and distearyl thiodipropionate (European Pharmacopoeia plastic additive 17). Results were analyzed using a toxicological procedure established for this study. Some phthalates and bisphenol A were detected in several samples, but only one contaminant, diisobutyl phthalate (DiBP), was found to be above the set concentration threshold. Using toxicological data, this concentration was found to be safe for users. 96% ethanol appeared to be the strongest simulant in term of extraction, with a maximum concentration of 491 µg/L for DiBP in a 100% styrene-acrylonitrile copolymer packaging. In water simulants, less contaminants were extracted, with concentrations under 20 µg/L.