ABSTRACT
We carried out a randomized, double-blind, placebo-controlled trial of Nonathymulin (NT, synthetic serum thymic factor) in patients with evolutive multiple sclerosis (MS) and moderate disability. Forty matched patients were treated with subcutaneous NT or placebo for 6 months and followed for another 6 months. There was no significant difference in treatment and control groups in the Kurtzke. Disability scores, Ambulation Index and Functional Scale. No significant side effects were recorded. NT is not effective in treating evolutive and moderately disabled MS.
Subject(s)
Multiple Sclerosis/drug therapy , Thymic Factor, Circulating/therapeutic use , Thymus Hormones/therapeutic use , Adult , Double-Blind Method , Female , Humans , Male , Middle Aged , Thymic Factor, Circulating/adverse effectsABSTRACT
The antiviral activity of a novel biological response modifier (murabutide MDP derivative) has been investigated in 3-week-old OF1 mice infected with influenza (A/Texas/1/77) virus. In each experimental and control group, 10 mice were infected intranasally with a viral dose producing 50% mortality in 5 days and received murabutide via the subcutaneous or intranasal route at various doses either in a simple or in daily repeated administration. All experiments were done in triplicate. Significant prophylactic or therapeutic effects were observed when murabutide was administered the same day as virus, 4 days or 2 days before virus, and 2 days later. These effects varied with the route of administration and the doses of the compound.
Subject(s)
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives , Orthomyxoviridae Infections/prevention & control , Acetylmuramyl-Alanyl-Isoglutamine/administration & dosage , Acetylmuramyl-Alanyl-Isoglutamine/therapeutic use , Administration, Intranasal , Animals , Dose-Response Relationship, Drug , Influenza A Virus, H3N2 Subtype , Influenza A virus , Injections, Subcutaneous , MiceSubject(s)
Graft Rejection/drug effects , Immunosuppressive Agents/pharmacology , Peptides, Cyclic/pharmacology , Skin Transplantation , Animals , Dose-Response Relationship, Immunologic , Female , H-2 Antigens/immunology , H-Y Antigen/immunology , Macrophage Activation/drug effects , Male , Mice , Mice, Inbred A , Mice, Inbred C57BL , Mice, Inbred CBASubject(s)
Macrophages/drug effects , Peptides, Cyclic/pharmacology , Animals , Antineoplastic Agents , Bacteria/drug effects , Chemotaxis/drug effects , Glucosamine/metabolism , In Vitro Techniques , Mice , Parasites/drug effects , Phagocytosis/drug effects , Rats , Rats, Inbred F344 , Stimulation, Chemical , Superoxides/metabolismABSTRACT
The use of both SEM and TEM techniques in studying the alterations of the columnar ciliated epithelium of the whole respiratory tract of ferrets enables the authors to find a significant discrepancy between tracheal and nasal mucosa destructions. This discrepancy is not a function of the anatomical location of virus instillation. Theoretical and pratical meanings are discussed.
