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1.
Ann Am Thorac Soc ; 20(12): 1743-1751, 2023 12.
Article in English | MEDLINE | ID: mdl-37769182

ABSTRACT

Rationale: Being overweight or obese is common among patients with chronic obstructive pulmonary disease (COPD), but whether interventions targeted at weight loss improve functional impairments is unknown. Objectives: INSIGHT (Intervention Study in Overweight Patients with COPD) tested whether a pragmatic low-intensity lifestyle intervention would lead to better physical functional status among overweight or obese participants with COPD. Methods: The trial was a 12-month, multicenter, patient-level pragmatic clinical trial. Participants were recruited from April 2017 to August 2019 from 38 sites across the United States and randomized to receive usual care or usual care plus lifestyle intervention. The intervention was a self-directed video program delivering the Diabetes Prevention Program's Group Lifestyle Balance curriculum. Results: The primary outcome was 6-minute-walk test distance at 12 months. Priority secondary outcomes were postwalk modified Borg dyspnea at 12 months and weight at 12 months. Participants (N = 684; mean age, 67.0 ± 8.0 yr [standard deviation]; 41.2% female) on average were obese (body mass index, 33.0 ± 4.6 kg/m2) with moderate COPD (forced expiratory volume in 1 second % predicted, 58.1 ± 15.7%). At 12 months, participants randomized to the intervention arm walked farther (adjusted difference, 42.3 ft [95% confidence interval (CI), 7.9-76.7 ft]; P = 0.02), had less dyspnea at the end of the 6-minute-walk test (adjusted difference, -0.36 [95% CI, -0.63 to -0.09]; P = 0.008), and had greater weight loss (adjusted difference, -1.34 kg [95% CI, -2.33 to -0.34 kg]; P = 0.008) than control participants. The intervention did not improve the odds of achieving clinically meaningful thresholds of walk distance (98.4 ft) or dyspnea (1 unit) but did achieve meaningful thresholds of weight loss (3% and 5%). Conclusions: Among participants with COPD who were overweight or obese, a self-guided low-intensity video-based lifestyle intervention led to modest weight loss but did not lead to clinically important improvements in physical functional status and dyspnea. Clinical trial registered with www.clinicaltrials.gov (NCT02634268).


Subject(s)
Overweight , Pulmonary Disease, Chronic Obstructive , Humans , Female , Middle Aged , Aged , Male , Overweight/complications , Overweight/therapy , Quality of Life , Pulmonary Disease, Chronic Obstructive/complications , Pulmonary Disease, Chronic Obstructive/therapy , Life Style , Dyspnea/etiology , Dyspnea/therapy , Obesity/complications , Obesity/therapy , Weight Loss
2.
Am J Manag Care ; 25(1): 26-31, 2019 01.
Article in English | MEDLINE | ID: mdl-30667608

ABSTRACT

OBJECTIVES: To describe and evaluate the impact of primary and specialty care integration via asynchronous communication at a large integrated healthcare system. STUDY DESIGN: In January 2014, Geisinger's primary care providers (PCPs) were given access to an asynchronous communication tool, Ask-a-Doc (AAD), that enabled direct communication with specialists in 14 medical specialties and 5 surgical specialties. Internal data were collected to assess PCPs' acceptance and use of the tool, as well as satisfaction. Insurance claims data were obtained to assess the impact on healthcare utilization and cost. METHODS: A retrospective analysis of health plan claims data was conducted among those patients who had at least 1 specialist visit with 1 of the participating specialties between January 2014 and December 2016. A set of difference-in-differences multivariate linear regression models with patient fixed effects was estimated, in which those who were not exposed to AAD served as the comparison group. RESULTS: Acceptance and use of AAD among PCPs gradually increased over time but varied by specialty. AAD was associated with an approximately 14% reduction in total cost of care during the first month of follow-up and a 20% reduction (P <.001) during the second month. These reductions in cost of care appeared to be driven by reductions in emergency department visits and physician office visits. CONCLUSIONS: Geisinger's AAD experience suggests that the integration of primary and specialty care via the use of a highly reliable and efficient asynchronous communication system can potentially lead to reductions in avoidable care and more efficient use of specialty care.


Subject(s)
Attitude of Health Personnel , Health Information Exchange , Patient Acceptance of Health Care/statistics & numerical data , Primary Health Care/organization & administration , Specialization , Aged , Communication , Female , Health Expenditures , Health Resources/economics , Health Resources/statistics & numerical data , Health Services/economics , Health Services/statistics & numerical data , Humans , Insurance Claim Review , Male , Middle Aged , Primary Health Care/economics , Referral and Consultation/organization & administration , Retrospective Studies
3.
Int J Chron Obstruct Pulmon Dis ; 12: 2515-2522, 2017.
Article in English | MEDLINE | ID: mdl-28883718

ABSTRACT

BACKGROUND: Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD), asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs) have not been previously reported. METHODS: We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS) cohorts enrolled annually from 2008 through 2012 for 1 year. MEPS is a prospective observational study of US households recording self-reported COPD, asthma, and ten medical conditions: angina, arthritis, cancer, coronary heart disease, cognitive impairment, diabetes, hypertension, lung cancer, myocardial infarction, and stroke/transient ischemic attack. We studied the separate contributions of these conditions to health care utilization (all-cause and respiratory disease hospitalization, any emergency department [ED] visit, and six or more outpatient visits) and PCOs (seven or more days spent in bed due to illness, incident loss of mobility, and incident decline in self-perceived health). RESULTS: COPD made the largest contributions to all-cause and respiratory disease hospitalization and ED visits, while arthritis made the largest contribution to outpatient health care. Arthritis and COPD, respectively, made the greatest contributions to the PCOs. CONCLUSION: COPD made the largest and second largest contributions to health care utilization and PCOs among US adults with obstructive airway disease. The twelve medical conditions collectively accounted for between 52% and 61% of the health care utilization outcomes and between 53% and 68% of the PCOs. Cognitive impairment, diabetes, hypertension, and stroke also made significant contributions.


Subject(s)
Asthma/therapy , Health Resources/statistics & numerical data , Patient-Centered Care , Pulmonary Disease, Chronic Obstructive/therapy , Adult , Aged , Ambulatory Care , Asthma/diagnosis , Asthma/economics , Asthma/epidemiology , Comorbidity , Emergency Service, Hospital , Female , Health Care Costs , Health Care Surveys , Health Expenditures , Health Resources/economics , Health Status , Hospitalization , Humans , Male , Middle Aged , Patient-Centered Care/economics , Prospective Studies , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/economics , Pulmonary Disease, Chronic Obstructive/epidemiology , Risk Factors , Time Factors , Treatment Outcome , United States/epidemiology
4.
Respir Med ; 107(10): 1568-77, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23806285

ABSTRACT

BACKGROUND: Administrative claims are an important data source for COPD research but lack a validated measure of patient COPD severity, which is an important determinant of treatment and outcomes. METHODS: Patients with ≥1 diagnosis of COPD and spirometry results from 01/2004-05/2011 were identified from an electronic health records database linked to healthcare claims. Patients were classified into 3 COPD severity groups based on spirometry and Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines: GOLD-Unclassified, Mild/Moderate, and Severe/Very Severe. A multinomial logistic regression model was constructed using claims data from 3 months before and after (observation period) the most recent spirometry (index date) to categorize patient COPD severity. A random selection of 90% of patients in each severity level was selected to build the model, and the remaining 10% were used as a validation sample. Model predictions were evaluated for sensitivity, specificity, accuracy, and concordance. RESULTS: Among 2028 COPD patients who met sample selection criteria, 886, 683, and 459 patients were in the GOLD-Unclassified, Mild/Moderate, and Severe/Very Severe categories, respectively. The final model included age, sex, comorbidities (such as pulmonary fibrosis and diabetes), COPD-related resource utilization (such as oxygen use), and all-cause healthcare utilization. In the validation sample, the model correctly predicted COPD severity for 62.7% of all patients (accuracy for predicting GOLD-Unclassified: 73.5%; Mild/Moderate: 70.6%; Severe/Very Severe: 81.4%) with kappa = 0.41. CONCLUSIONS: The prediction model was developed using clinically measured COPD severity to provide researchers an approach to classify patients using claims data when clinical measures are not available.


Subject(s)
Pulmonary Disease, Chronic Obstructive/diagnosis , Severity of Illness Index , Aged , Aged, 80 and over , Comorbidity , Databases, Factual , Delivery of Health Care/statistics & numerical data , Female , Forced Expiratory Volume/physiology , Humans , Insurance Claim Review , Logistic Models , Male , Middle Aged , Pennsylvania/epidemiology , Pulmonary Disease, Chronic Obstructive/epidemiology , Pulmonary Disease, Chronic Obstructive/physiopathology , Pulmonary Disease, Chronic Obstructive/therapy , Spirometry , Vital Capacity/physiology
5.
Am J Med Sci ; 341(6): 500-3, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21613935

ABSTRACT

A 79-year-old Asian man was admitted with community-acquired pneumonia. Antimycobacterial therapy was initiated when sputum smears revealed acid fast bacilli. The patient was, however, diagnosed to have pneumonia secondary to Tsukamurella spp. This is an exceedingly rare cause of pneumonia, especially in immunocompetent individuals. Clinical presentation, diagnosis and treatment strategies of Tsukamurella pneumonia are discussed with a literature review.


Subject(s)
Actinomycetales Infections/diagnosis , Actinomycetales Infections/drug therapy , Actinomycetales/isolation & purification , Anti-Bacterial Agents/therapeutic use , Pneumonia/diagnosis , Pneumonia/drug therapy , Actinomycetales Infections/microbiology , Aged , Community-Acquired Infections/drug therapy , Community-Acquired Infections/microbiology , Diagnosis, Differential , Fluoroquinolones/therapeutic use , Humans , Male , Pneumonia/microbiology
6.
J Thorac Cardiovasc Surg ; 133(6): 1434-8, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17532935

ABSTRACT

OBJECTIVES: We hypothesized that lung-volume reduction surgery for pulmonary emphysema would improve body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index, a multidimensional predictor of survival in chronic obstructive pulmonary disease. We also aimed to identify preoperative predictors of improvement in the BODE index. METHODS: In a prospective cohort study of patients undergoing lung-volume reduction surgery at our center, with the methodology of the National Emphysema Treatment Trial, we compared clinical characteristics before and 1 year after surgery with the Wilcoxon signed rank test. Changes in the BODE index were correlated with preoperative variables with the Spearman correlation coefficient. RESULTS: Twenty-three patients with predominantly upper-lobe pulmonary emphysema underwent lung-volume reduction surgery (14 by video-assisted thoracoscopic surgery, 9 by median sternotomy). There were no postoperative or follow-up deaths. The BODE index improved from a median of 5 (interquartile range 4-5) before surgery to 3 (interquartile range 2-4) 1 year after surgery (P < .0001). Improvements were seen in the lung function and dyspnea components of the BODE index. Lower preoperative 6-minute walk distance and lower postwalk Borg fatigue scores were each associated with greater improvement in the BODE index after 1 year. CONCLUSION: Lung-volume reduction surgery for pulmonary emphysema improved the BODE index in patients with predominantly upper-lobe disease. Lower preoperative 6-minute walk distance correlated with greater improvement in the BODE index.


Subject(s)
Pneumonectomy/methods , Pulmonary Emphysema/physiopathology , Pulmonary Emphysema/surgery , Severity of Illness Index , Airway Obstruction/physiopathology , Body Mass Index , Dyspnea/physiopathology , Exercise Tolerance , Female , Humans , Lung Volume Measurements , Male , Middle Aged , Patient Selection , Predictive Value of Tests , Prospective Studies , Respiratory Function Tests , Risk Factors , Statistics, Nonparametric , Survival Analysis
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