Structure of leukemias and lymphomas in children of Ukraine in post-Chernobyl period.

The structure of hematopoietic malignancies in post-Chernobyl period among pediatric patients in Kyiv city and 24 regions of Ukraine especially those born in 1986 and 1987 and the infants at the age below 1 year is reviewed taking into account the data of the Reference Laboratory obtained in 1993-2004 and based on the modern diagnostic technologies in accordance with FAB, WHO, EGIL, ICD-10 and ICD-O-2 classifications.

[Management of 29 children with thyroid cancer following the Chernobyl accident]. / Prise en charge de 29 enfants atteints de cancer de la thyroïde à la suite de l'accident de Tchernobyl.

As a consequence of the Chernobyl nuclear power plant accident, a considerable increase of thyroid cancer among contaminated children has been reported in Ukraine, Belarus and Russia. A group of 29 children aged from 5 months to 10 years (mean 4.7 years) at the time of the accident, with a papillary thyroid cancer, have been examined at the Pitié-Salpêtrière hospital in Paris. The cancer was discovered by systematic ultrasonography in only 25% of cases. No reliable dosimetric estimation was achieved. The initial surgical treatment was performed in Ukraine. Cervical lymph node and pulmonary metastases were present in 24 and 11 cases respectively. A complementary surgical treatment was necessary for 9 children and one to four radioiodine treatments were given to 24 children. With a mean delay of 7 years after the cancer discovery, an apparent cure or a remission was obtained for 20 children, 6 children have cervical lymph node metastases requiring a surgical treatment and 3 have evolving lung metastases. The management of the great number of foreseeable cases of thyroid cancer requires an improved systematic screening, a large number of rooms dedicated to high activity radioiodine treatments, funds for disposable material and training missions.

Anaplastic small cell (oat cell) carcinoma of the tonsils: report of two cases.

Two cases of anaplastic small cell (oat cell) carcinoma of the tonsils are presented. In the first, cervical metastases preceded the manifestation of the primary tumour by 2 years. In case 2 the tonsillar carcinoma was accompanied by a bronchial tumour of the same histological type and by cervical and axillary metastases. Positive Grimelius stain, positive immunohistochemical staining for chromogranin A and neurone-specific enolase and the presence, in case 1, of membrane-bound granules indicate that these tumours display many similarities with neuroendocrine carcinomas even if they originate from pluripotential ductal cells of tonsillar minor salivary glands and not from Kulchitsky-like cells.

S-100 protein expression in satellite and Schwann cells in neuroblastoma. An immunohistochemical and ultrastructural study.

Immunohistochemical evidence has recently been provided that in the normal adrenal medulla as well as in autonomic ganglia, satellite cells and Schwann cells react with S-100 protein antiserum. In the light of these data, we investigated primary peripheral neuroblastoma and ganglioneuroblastoma to determine firstly whether both cell populations actually exist in the malignancies, using the definite criteria of electron microscopy for their identification, and secondly whether they express S-100 protein using on immunohistochemical technique and light microscopy. The results indicate that in both neuroblastoma variants, satellite and Schwann cells are present and specifically express the S-100 antigen.

Tubular arrays in cerebrospinal fluid cells: their location within smooth endoplasmic reticulum cisternae.

Unique ultrastructural formations termed tubular arrays have been reported in a variety of renal diseases, viral infections, malignant tumors, and other circumstances. This report describes identical structures in monocytes in the cerebrospinal fluid in a case of pneumococcal meningitis. The occurrence, previously unreported, of tubular arrays in this infection and this kind of cell supports the growing view that tubular arrays probably do not represent viral components, but rather a general reactive phenomenon of the cell. In addition, ultrastructural findings are presented suggesting that tubular arrays appear to be located in the cisternae of the endoplasmic reticulum with major involvement of its smooth compartment.

Ultrastructure of clear cell carcinoma of the vagina and the cervix. Report of a case with unusual ultrastructural findings.

PIP: The ultrastructural study of a primary adenocarcinoma of the vagina with no history of maternal medication is described. A 27 year old girl was found to have a clear cell adenocarcinoma. The striking feature was the presence of vesicular aggregates in a large proportion of the nuclei. The aggregates consisted of vesicles from 600 to 850 A in diameter and characterized by a single smooth membrane. The aggregates were located in the nucleoplasm, the perinuclear cytoplasm, or between the 2 membranes of the nuclear envelope.^ieng