ABSTRACT
In order to reevaluate effectiveness of iodine prophylaxis in Macedonia, epidemiological, ultrasonographic studies and estimation of urine excretion were performed. The results from the epidemiological survey in nongoitrogenic regions demonstrated goiter between 12.8% and 18%. Much higher prevalence of goiter was found in goitrogenic regions, between 20.8% and 60.8%. The incidence of goiter increased with age, and its prevalence is higher in girls when compared with the boys of the same age group. The thyroid volume estimated by ultrasonography was higher in children from goitrogenic regions when compared to nongoitrogenic. There was a good correlation between ultrasonographic volumetry data and size of the thyroid estimated by palpation. Urinary iodine excretion demonstrated low values in children from goitrogenic regions as indicator of iodine deficiency.
Subject(s)
Goiter, Endemic/prevention & control , Iodine/therapeutic use , Adolescent , Child , Female , Goiter, Endemic/diagnostic imaging , Goiter, Endemic/epidemiology , Humans , Male , Republic of North Macedonia/epidemiology , UltrasonographyABSTRACT
The results are presented of a 3-17 years' prolongation of the usual one-year "long-term" drug treatment applied to patients with Graves' disease. Most of the 87 patients with an average age of 34.3 years were on the maintenance dose of 10 mg methimazole daily. This mono-drug therapy was well tolerated and accepted by the patients, the toxic state disappeared, glandular consistency and the size remained almost unchanged. Thirty-six patients of this group (41.4%) were in a "permanent" remission lasting over three years. The remaining 51 patients continued their maintenance dose which kept a balanced euthyroid state. The authors support the convenience of a considerable extension of the traditional long-term methimazole treatment of Graves' disease. This extended scheme of the drug suppression of euthyroid functions is reversible in contrast to radical surgical or radioiodine treatments which increase the cumulative rate of irreversible hypothyroidism over decades.
Subject(s)
Graves Disease/drug therapy , Methimazole/administration & dosage , Adolescent , Adult , Aged , Child , Humans , Methimazole/adverse effects , Methimazole/therapeutic use , Middle Aged , Time FactorsSubject(s)
Thyroid Neoplasms/diagnosis , Female , Male , Thyroid Neoplasms/epidemiology , YugoslaviaABSTRACT
A visualization of the bone marrow beside that of the spleen was obtained with 99mTc-labeled N-ethylmaleimide (NEM) damaged erythrocytes in a patient with systemic lupus erythematosus. This phenomenon could be produced both with autologous and homologous red cells. The patient's NEM-damaged erythrocytes given to a healthy patient did not produce a visualization of the marrow. Such an observation was not present in a series of healthy persons and patients with different disorders to whom labeled and damaged erythrocytes were administered, and has not been reported in the literature so far.
Subject(s)
Bone Marrow/diagnostic imaging , Erythrocytes , Technetium , Child , Erythrocytes/drug effects , Ethylmaleimide , Female , Humans , Lupus Erythematosus, Systemic/diagnostic imaging , Radionuclide Imaging , Spleen/diagnostic imagingSubject(s)
Hyperthyroidism/complications , Vitiligo/complications , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle AgedABSTRACT
As shown the inhibitory effect of aspirin administered in vivo on platelet aggregation and factor 3 release in vitro was due to the action of aspirin on the blood platelets and plasma cofactors: plasma from aspirinized rats dimished aggregability of platelets from untreated animals; plasma from untreated rats increased the aggregability and factor 3 availability of platelets from aspirinized animals.
