Characterization of the PSG11 gene.

The pregnancy-specific beta 1-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosomes 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, Cw, Cr, and Cs, which are expected from the transcripts characterized. Down-stream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes.

Relaxation training as a technique for helping patients cope with the experience of cancer: a selective review of the literature.

The experience of cancer places considerable physiological and psychological demands upon the patient. In recent years the potential benefits of relaxation training have generated widespread interest in both the lay and professional literature, particularly in the area of stress management. This paper examines the use of relaxation training as a method for helping patients cope with the experience of cancer and reviews a number of studies which have used progressive muscle relaxation and guided imagery in the oncology setting. Although these studies have produced some encouraging results, there are a number of issues which need to be addressed if future relaxation studies are to be useful for nursing practice, and these are discussed.