ABSTRACT
Stress response caused by events such as surgical trauma includes endocrine, metabolic and immunological changes. Stress hormones and cytokines play a role in these reactions. More reactions are induced by greater stress, ultimately leading to greater catabolic effects. Cuthbertson reported the characteristic response that occurs in trauma patients: protein and fat consumption and protection of body fluids and electrolytes because of hypermetabolism in the early period. The oxygen and energy requirement increases in proportion to the severity of trauma. The awareness of alterations in amino acid, lipid, and carbohydrate metabolism changes in surgical patients is important in determining metabolic and nutritional support. The main metabolic change in response to injury that leads to a series of reactions is the reduction of the normal anabolic effect of insulin, i.e. the development of insulin resistance. Free fatty acids are primary sources of energy after trauma. Triglycerides meet 50 to 80 % of the consumed energy after trauma and in critical illness. Surgical stress and trauma result in a reduction in protein synthesis and moderate protein degradation. Severe trauma, burns and sepsis result in increased protein degradation. The aim of glucose administration to surgical patients during fasting is to reduce proteolysis and to prevent loss of muscle mass. In major stress such as sepsis and trauma, it is important both to reduce the catabolic response that is the key to faster healing after surgery and to obtain a balanced metabolism in the shortest possible time with minimum loss. For these reasons, the details of metabolic response to trauma should be known in managing these situations and patients should be treated accordingly.
ABSTRACT
OBJECTIVE: Previous reports suggest that maternal exposure to acute stress related to earthquakes affects the sex ratio at birth. Our aim was to examine the change in sex ratio at birth after Eastern Marmara earthquake disasters. MATERIAL AND METHODS: This study was performed using the official birth statistics from January 1997 to December 2002 - before and after 17 August 1999, the date of the Golcuk Earthquake - supplied from the Turkey Statistics Institute. The secondary sex ratio was expressed as the male proportion at birth, and the ratio of both affected and unaffected areas were calculated and compared on a monthly basis using data from gender with using the Chi-square test. RESULTS: We observed significant decreases in the secondary sex ratio in the 4th and 8th months following an earthquake in the affected region compared to the unaffected region (p= 0.001 and p= 0.024). In the earthquake region, the decrease observed in the secondary sex ratio during the 8th month after an earthquake was specific to the period after the earthquake. CONCLUSION: Our study indicated a significant reduction in the secondary sex ratio after an earthquake. With these findings, events that cause sudden intense stress such as earthquakes can have an effect on the sex ratio at birth.
