[The role of pyridine nucleotide cofactors in the reaction of microsomal N-demethylation under normal conditions and in tumor pathology]. / Uchastie piridinnukleotidnykh kofaktorov v reaktsii mikrosomal'nogo N-demetilirovaniia v norme i pri opukholevoi patologii.

Functions of pyridine nucleotide cofactors NADPH and NADH in N-demethylation of amidopyrine were studied under conditions of normal and malignant states. Contribution of NADH-specific transfer of electrons to microsomal N-demethylation was gradually augmented in the sequence: microsomes from liver tissue of rats with Zajdela hepatoma--microsomes of ascites hepatocytes. In this sequence both synergic effect of these cofactors and the rate of N-demethylcation, if NADH was used as a cofactor, were increased.