ABSTRACT
In a double-blind randomized study 150 outpatients receivng the same anesthetic for first trimester therapeutic abortions were equally divided into three groups: control; droperidol, 2.5 mg IM; or hydroxyzine, 100 mg IM. The injection was given immediately after thiamylal (Surital) induction of anesthesia, and the incidence of nausea, retching, or vomiting (NRV) was recorded at 15-minute intervals for 3 hours after surgery. NRV occurred in 56% of control patients, in 44% of patients given droperidol, and in 10% of patients given hydroxyzine. The patients receiving hydroxyzine and droperidol were more sedated and experienced a delay in return of hand-eye coordination as measured by the time for the Trieger motor test to reach preoperative levels. All patients equaled their preoperative performance during the 3rd hour after surgery and were discharged 4 hours following general anesthesia. We conclude that intramuscular hydroxyzine hydrochloride, 100 mg, is a significantly better antiemetic than intramuscular droperidol, 2.5 mg.
Subject(s)
Antiemetics , Droperidol/pharmacology , Hydroxyzine/pharmacology , Abortion, Induced , Double-Blind Method , Droperidol/administration & dosage , Drug Evaluation , Female , Humans , Hydroxyzine/administration & dosage , Injections, Intramuscular , Nausea/physiopathology , Pregnancy , Pregnancy Complications/physiopathology , Random Allocation , Sleep/drug effectsABSTRACT
Sub-dissociative doses of ketamine compared unfavourably with methohexitonenitrous oxide anaesthesia for dilatation, evacuation and curettage. We could not separate the desirable effects of analgesia and amnesia from the unwanted dream effects and visual disturbances. Although the time of clinical recovery was similar, the Trieger Motor Test revealed a delay in return to normal in both groups.
Subject(s)
Anesthesia, Intravenous , Dilatation and Curettage , Ketamine , Methohexital , Adolescent , Adult , Amnesia/chemically induced , Analgesia , Anesthesia, Inhalation , Communication , Consciousness , Dreams , Female , Humans , Ketamine/administration & dosage , Methohexital/administration & dosage , Orientation/drug effects , Time Factors , Visual Perception/drug effectsABSTRACT
Experience with 88 obese pateints undergoing jejunoileal shunt is reviewed, with emphasis on preoperative preparation and assessment, conduct of anesthesia, postoperative care, and anesthesia-related complications. There was no intraoperative mortality, and postoperative morbidity was minimal. The operation can be viewed as a short-term answer to the malignancy of massive obesity, since physiologic abnormalities are reversible; however, only hospitals that can provide full surgical, medical, endocrinologic, and anesthesia services, backed by modern ancillary investigative ability, should perform this operation.
