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[POLYMORPHISM OF GLUTHATIONE-S-TRANSFERASE P1 IN CHILDREN WITH REFLUX-ESOPHAGITIS].

Zagorskiy, S E; Melnov, S B; Sinevich, E A.

Lik Sprava ; (1-2): 134-5, 2015.

Article in Russian | MEDLINE | ID: mdl-26118046

ABSTRACT

The distribution of allele and genotype frequencies of genes of xenobiotic detoxication (CYP2E1--PstI, RsaI, DraI; ADH, ALDH, NAT2, GSTP1, GSTM1, GSTT1) was examined in 147 patients with reflux-esophagitis (RE) and 50 conditionally healthy children 12-18 years. The frequency of AA genotype of GSTP1 gene and A allele was significantly higher in patients with RE as compared with healthy children (χ2 = 4.93; P = 0.03 and χ2 = 5.94; P = 0.01 respectively).

Subject(s)

Esophagitis, Peptic/genetics , Glutathione S-Transferase pi/genetics , Polymorphism, Genetic , Adolescent , Aldehyde Dehydrogenase/genetics , Alleles , Arylamine N-Acetyltransferase/genetics , Case-Control Studies , Child , Cytochrome P-450 CYP2E1/genetics , Esophagitis, Peptic/pathology , Female , Gene Expression , Gene Frequency , Genotype , Glutathione Transferase/genetics , Humans , Male , Neurophysins/genetics , Protein Precursors/genetics , Vasopressins/genetics

ABSTRACT

Subject(s)

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