Gastrointestinal Bleeding Caused by Large Intestine Amyloidosis.

Background: Amyloidosis is a rare disorder caused by abnormal folding of proteins, leading to the dysfunction of normal tissues. Amyloid deposition can affect several organs, but deposition in the large intestine is rare. Case Presentation: A 79-year-old man presented with gastrointestinal bleeding and nonspecific symptoms of weight loss, dry heaves, dysphagia, and weakness. The patient underwent esophagogastroduodenoscopy and colonoscopy and a biopsy confirmed the diagnosis of intestinal amyloidosis. Conclusions: This case report highlights the importance of a strong differential when working up gastrointestinal bleeding that includes amyloidosis. Early identification and multidisciplinary involvement are crucial for management and tailored care to each patient's needs.

Assessing adherence and cost-benefit of colorectal cancer screening for accountable providers.

The objective of this study was to assess adherence and costs-benefits of colorectal cancer (CRC) screenings from an accountable care organization/population health perspective. We performed a retrospective review of 94 patients (50-75 years of age) in an integrated safety net system for whom fecal CRC screening was abnormal for the period of June 1, 2014, to June 1, 2016. A cost-benefit model was constructed using Medicare payment rates and a sensitivity analysis. Most patients included in the study (64/94, 68%) received or were offered a colonoscopy. Of those receiving a colonoscopy, 24 of 45 (53%) had an abnormal finding. Total direct medical costs avoided by screening the patient panel was $32,926 but could have exceeded $63,237 had more patients received follow-up colonoscopies. A sensitivity analysis with 1000 patients demonstrated total monetary benefits between $2.2 million and $8.16 million when follow-up and colonoscopy rates were allowed to vary. Although the resulting rates of follow-up were within the range reported in the literature, there is room for improvement, especially considering the monetary benefit that could be used on other diseases. Health systems and payers should work cooperatively to structure payment models to better incentivize CRC screenings.

Review of endoscopic techniques in the diagnosis and management of cholangiocarcinoma.

Cholangiocarcinoma is a rare malignancy of the biliary tract. Key factors in determining therapeutic options include knowledge of tumor extent, anatomy and obtaining tissue diagnosis. Endoscopically, there are three modalities available to make the diagnosis of cholangiocarcinoma. These include endoscopic retrograde cholangiopancreatography, endoscopic ultrasound with fine needle aspiration and cholangioscopy. Management of cholangiocarcinoma endoscopically is typically confined to stent placement for palliative purposes or as a bridge to surgery. In this article, we will review the endoscopic techniques available for the diagnosis and management of cholangiocarcinoma.

An in vitro analysis of microbial transmission during EUS-guided FNA and the utility of sterilization agents.

BACKGROUND: The risk of infection and potential microbial transmission with EUS-guided FNA (EUS-FNA) of cystic lesions remains unknown. OBJECTIVE: We developed an in vitro model to study the incidence of transmucosal microbial transmission during EUS-FNA of cystic lesions and to evaluate the in vitro efficacy of bacteriocidal agent washings of mucosa before FNA under experimental conditions. DESIGN: Conical tubes, 15 mL, filled with aerobic blood culture bottle media were prepared. Then sterile sections of bovine tripe were fastened over the top of the conical tubes in a sterile fashion (conical tube-tripe unit). FNA was performed with 22-gauge FNA needles. A series of 6 experiments were performed. Ten conical tube-tripe units underwent FNA once through the tripe into the blood culture media to ensure sterility. The surface of 10 conical tube-tripe units were inoculated with 50 microL of a 1.5 x 10(8) 1:1 mixture of Escherichia coli (E coli) and Enterococcus sp, and FNA was performed one time into the blood culture media to ensure contamination (controls). The surface of 40 conical tube-tripe units were inoculated with 50 microL of a 1.5 x 10(8) 1:1 mixture of E coli and Enterococcus sp Each of 4 sets of 10 conical tube-tripe units underwent experimental scenarios that consisted of washings with either 1 mL of 0.5% povidone iodine, chlorhexidine, absolute ethanol, or sterile water. FNA was performed once through the tripe into the blood culture media after washing the surface of the tripe. After each conical tube-tripe unit underwent FNA one time, 1 mL blood culture media was obtained and mixed on pour plate agar media and was incubated along with the conical tubes. Microbial evaluation of the conical tubes that contained the blood culture media and pour plates was performed after 48 hours of incubation. SETTING: Gastroenterology and Microbiology Departments of Scott White Memorial Hospital and Clinic in Temple, Texas. INTERVENTIONS: EUS-FNA of cystic lesions. MAIN OUTCOME MEASUREMENTS: Microbial contamination during EUS-FNA of an in vitro cystic environment. RESULTS: A control without E coli and Enterococcus sp was with 0% contamination. A control group with E coli and Enterococcus sp was with 100% contamination; sterile water washings, 100% contamination (P = 1.00); iodine washings, 20% contamination (P < .001); chlorhexidine washings, 80% contamination (P = .47); and absolute ethanol washings, 90% contamination (P = 1.00). Results were compared with our control group by statistical tests of proportions by using the Fisher exact test. CONCLUSIONS: EUS-FNA of sterile cystic lesions resulted in transmucosal microbial contamination. However, our model demonstrated that iodine sterilization of a contaminated mucosal surface produced a very highly statistically significant (P < .001) reduction in the transmission of infectious agents into a sterile environment. This in vitro model could translate into clinical practice by providing evidence that microbial transmission by FNA occurred. The utility of povidone iodine washings could alter procedure methods and patient care.