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Chemical examination of the Sponge Phycopsis sp.
Kondempudi, Chinni Mahesh; Singanaboina, Rajaram; Manchala, Narasimhulu; Gunda, Venu Gopal; Janapala, Venkateswara Rao; Yenamandra, Venkateswarlu.
Chem Pharm Bull (Tokyo) ; 57(9): 990-2, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19721262

ABSTRACT

Two new compounds 7alpha,8alpha-epoxy theonellin isothiocyanate (1) and 5alpha,8alpha-epidioxyergosta-6Z,22Z,25-trien-3beta-ol (2) along with two known compounds, theonellin isothiocyanate (3) and theonellin formamide (4) have been isolated from the sponge Phycopsis sp. Compound 2 showed cytotoxic activity against HL-60 and U937 human cancer cell lines with IC(50) values of 5.96+/-0.02 and 31.72+/-0.55 microg/ml, respectively.


Subject(s)
Antineoplastic Agents/chemistry , Dioxanes/chemistry , Ergosterol/analogs & derivatives , Isothiocyanates/chemistry , Porifera/chemistry , Animals , Antineoplastic Agents/isolation & purification , Antineoplastic Agents/toxicity , Cell Line, Tumor , Dioxanes/isolation & purification , Dioxanes/toxicity , Drug Screening Assays, Antitumor , Ergosterol/chemistry , Ergosterol/isolation & purification , Ergosterol/toxicity , Humans , Isothiocyanates/isolation & purification , Isothiocyanates/toxicity , Magnetic Resonance Spectroscopy
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