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1.
JAMA ; 331(18): 1544-1557, 2024 05 14.
Article in English | MEDLINE | ID: mdl-38557703

ABSTRACT

Importance: Infections due to multidrug-resistant organisms (MDROs) are associated with increased morbidity, mortality, length of hospitalization, and health care costs. Regional interventions may be advantageous in mitigating MDROs and associated infections. Objective: To evaluate whether implementation of a decolonization collaborative is associated with reduced regional MDRO prevalence, incident clinical cultures, infection-related hospitalizations, costs, and deaths. Design, Setting, and Participants: This quality improvement study was conducted from July 1, 2017, to July 31, 2019, across 35 health care facilities in Orange County, California. Exposures: Chlorhexidine bathing and nasal iodophor antisepsis for residents in long-term care and hospitalized patients in contact precautions (CP). Main Outcomes and Measures: Baseline and end of intervention MDRO point prevalence among participating facilities; incident MDRO (nonscreening) clinical cultures among participating and nonparticipating facilities; and infection-related hospitalizations and associated costs and deaths among residents in participating and nonparticipating nursing homes (NHs). Results: Thirty-five facilities (16 hospitals, 16 NHs, 3 long-term acute care hospitals [LTACHs]) adopted the intervention. Comparing decolonization with baseline periods among participating facilities, the mean (SD) MDRO prevalence decreased from 63.9% (12.2%) to 49.9% (11.3%) among NHs, from 80.0% (7.2%) to 53.3% (13.3%) among LTACHs (odds ratio [OR] for NHs and LTACHs, 0.48; 95% CI, 0.40-0.57), and from 64.1% (8.5%) to 55.4% (13.8%) (OR, 0.75; 95% CI, 0.60-0.93) among hospitalized patients in CP. When comparing decolonization with baseline among NHs, the mean (SD) monthly incident MDRO clinical cultures changed from 2.7 (1.9) to 1.7 (1.1) among participating NHs, from 1.7 (1.4) to 1.5 (1.1) among nonparticipating NHs (group × period interaction reduction, 30.4%; 95% CI, 16.4%-42.1%), from 25.5 (18.6) to 25.0 (15.9) among participating hospitals, from 12.5 (10.1) to 14.3 (10.2) among nonparticipating hospitals (group × period interaction reduction, 12.9%; 95% CI, 3.3%-21.5%), and from 14.8 (8.6) to 8.2 (6.1) among LTACHs (all facilities participating; 22.5% reduction; 95% CI, 4.4%-37.1%). For NHs, the rate of infection-related hospitalizations per 1000 resident-days changed from 2.31 during baseline to 1.94 during intervention among participating NHs, and from 1.90 to 2.03 among nonparticipating NHs (group × period interaction reduction, 26.7%; 95% CI, 19.0%-34.5%). Associated hospitalization costs per 1000 resident-days changed from $64 651 to $55 149 among participating NHs and from $55 151 to $59 327 among nonparticipating NHs (group × period interaction reduction, 26.8%; 95% CI, 26.7%-26.9%). Associated hospitalization deaths per 1000 resident-days changed from 0.29 to 0.25 among participating NHs and from 0.23 to 0.24 among nonparticipating NHs (group × period interaction reduction, 23.7%; 95% CI, 4.5%-43.0%). Conclusions and Relevance: A regional collaborative involving universal decolonization in long-term care facilities and targeted decolonization among hospital patients in CP was associated with lower MDRO carriage, infections, hospitalizations, costs, and deaths.


Subject(s)
Anti-Infective Agents, Local , Bacterial Infections , Cross Infection , Drug Resistance, Multiple, Bacterial , Health Facilities , Infection Control , Aged , Humans , Administration, Intranasal , Anti-Infective Agents, Local/administration & dosage , Anti-Infective Agents, Local/therapeutic use , Bacterial Infections/economics , Bacterial Infections/microbiology , Bacterial Infections/mortality , Bacterial Infections/prevention & control , Baths/methods , California/epidemiology , Chlorhexidine/administration & dosage , Chlorhexidine/therapeutic use , Cross Infection/economics , Cross Infection/microbiology , Cross Infection/mortality , Cross Infection/prevention & control , Health Facilities/economics , Health Facilities/standards , Health Facilities/statistics & numerical data , Hospitalization/economics , Hospitalization/statistics & numerical data , Hospitals/standards , Hospitals/statistics & numerical data , Infection Control/methods , Iodophors/administration & dosage , Iodophors/therapeutic use , Nursing Homes/economics , Nursing Homes/standards , Nursing Homes/statistics & numerical data , Patient Transfer , Quality Improvement/economics , Quality Improvement/statistics & numerical data , Skin Care/methods , Universal Precautions
2.
Infect Control Hosp Epidemiol ; : 1-4, 2024 Mar 05.
Article in English | MEDLINE | ID: mdl-38440877

ABSTRACT

We evaluated whether universal chlorhexidine bathing (decolonization) with or without COVID-19 intensive training impacted COVID-19 rates in 63 nursing homes (NHs) during the 2020-2021 Fall/Winter surge. Decolonization was associated with a 43% lesser rise in staff case-rates (P < .001) and a 52% lesser rise in resident case-rates (P < .001) versus control.

3.
J Am Med Dir Assoc ; 25(4): 639-646.e5, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38432644

ABSTRACT

OBJECTIVES: To evaluate the epidemiologic, clinical, and economic value of an annual nursing home (NH) COVID-19 vaccine campaign and the impact of when vaccination starts. DESIGN: Agent-based model representing a typical NH. SETTING AND PARTICIPANTS: NH residents and staff. METHODS: We used the model representing an NH with 100 residents, its staff, their interactions, COVID-19 spread, and its health and economic outcomes to evaluate the epidemiologic, clinical, and economic value of varying schedules of annual COVID-19 vaccine campaigns. RESULTS: Across a range of scenarios with a 60% vaccine efficacy that wanes starting 4 months after protection onset, vaccination was cost saving or cost-effective when initiated in the late summer or early fall. Annual vaccination averted 102 to 105 COVID-19 cases when 30-day vaccination campaigns began between July and October (varying with vaccination start), decreasing to 97 and 85 cases when starting in November and December, respectively. Starting vaccination between July and December saved $3340 to $4363 and $64,375 to $77,548 from the Centers for Medicare & Medicaid Services and societal perspectives, respectively (varying with vaccination start). Vaccination's value did not change when varying the COVID-19 peak between December and February. The ideal vaccine campaign timing was not affected by reducing COVID-19 levels in the community, or varying transmission probability, preexisting immunity, or COVID-19 severity. However, if vaccine efficacy wanes more quickly (over 1 month), earlier vaccination in July resulted in more cases compared with vaccinating later in October. CONCLUSIONS AND IMPLICATIONS: Annual vaccination of NH staff and residents averted the most cases when initiated in the late summer through early fall, at least 2 months before the COVID-19 winter peak but remained cost saving or cost-effective when it starts in the same month as the peak. This supports tethering COVID vaccination to seasonal influenza campaigns (typically in September-October) for providing protection against SARS-CoV-2 winter surges in NHs.


Subject(s)
COVID-19 Vaccines , COVID-19 , Aged , Humans , United States/epidemiology , COVID-19/epidemiology , COVID-19/prevention & control , SARS-CoV-2 , Medicare , Vaccination , Nursing Homes
4.
Infect Control Hosp Epidemiol ; 45(6): 754-761, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38356377

ABSTRACT

OBJECTIVE: Nursing home residents may be particularly vulnerable to coronavirus disease 2019 (COVID-19). Therefore, a question is when and how often nursing homes should test staff for COVID-19 and how this may change as severe acute respiratory coronavirus virus 2 (SARS-CoV-2) evolves. DESIGN: We developed an agent-based model representing a typical nursing home, COVID-19 spread, and its health and economic outcomes to determine the clinical and economic value of various screening and isolation strategies and how it may change under various circumstances. RESULTS: Under winter 2023-2024 SARS-CoV-2 omicron variant conditions, symptom-based antigen testing averted 4.5 COVID-19 cases compared to no testing, saving $191 in direct medical costs. Testing implementation costs far outweighed these savings, resulting in net costs of $990 from the Centers for Medicare & Medicaid Services perspective, $1,545 from the third-party payer perspective, and $57,155 from the societal perspective. Testing did not return sufficient positive health effects to make it cost-effective [$50,000 per quality-adjusted life-year (QALY) threshold], but it exceeded this threshold in ≥59% of simulation trials. Testing remained cost-ineffective when routinely testing staff and varying face mask compliance, vaccine efficacy, and booster coverage. However, all antigen testing strategies became cost-effective (≤$31,906 per QALY) or cost saving (saving ≤$18,372) when the severe outcome risk was ≥3 times higher than that of current omicron variants. CONCLUSIONS: SARS-CoV-2 testing costs outweighed benefits under winter 2023-2024 conditions; however, testing became cost-effective with increasingly severe clinical outcomes. Cost-effectiveness can change as the epidemic evolves because it depends on clinical severity and other intervention use. Thus, nursing home administrators and policy makers should monitor and evaluate viral virulence and other interventions over time.


Subject(s)
COVID-19 Testing , COVID-19 , Cost-Benefit Analysis , Nursing Homes , SARS-CoV-2 , Humans , Nursing Homes/economics , COVID-19/diagnosis , COVID-19/economics , COVID-19/prevention & control , COVID-19 Testing/economics , COVID-19 Testing/methods , United States
5.
Clin Infect Dis ; 2023 Dec 06.
Article in English | MEDLINE | ID: mdl-38059527

ABSTRACT

BACKGROUND: Environmental contamination is suspected to play an important role in Candida auris transmission. Understanding speed and risks of contamination after room disinfection could inform environmental cleaning recommendations. METHODS: We conducted a prospective multicenter study of environmental contamination associated with C. auris colonization at six ventilator-capable skilled nursing facilities and one acute-care hospital in Illinois and California. Known C. auris carriers were sampled at five body-sites followed by sampling of nearby room surfaces before disinfection and at 0, 4, 8, and 12-hours post-disinfection. Samples were cultured for C. auris and bacterial multidrug-resistant organisms (MDROs). Odds of surface contamination after disinfection were analyzed using multilevel generalized estimating equations. RESULTS: Among 41 known C. auris carriers, colonization was detected most frequently on palms/fingertips (76%) and nares (71%). C. auris contamination was detected on 32.2% (66/205) of room surfaces pre-disinfection and 20.5% (39/190) of room surfaces by 4-hours post-disinfection. A higher number of C. auris-colonized body sites was associated with higher odds of environmental contamination at every time point following disinfection, adjusting for facility of residence. In the rooms of 38 (93%) C. auris carriers co-colonized with a bacterial MDRO, 2%-24% of surfaces were additionally contaminated with the same MDRO by 4-hours post-disinfection. CONCLUSIONS: C. auris can contaminate the healthcare environment rapidly after disinfection, highlighting the challenges associated with environmental disinfection. Future research should investigate long-acting disinfectants, antimicrobial surfaces, and more effective patient skin antisepsis to reduce the environmental reservoir of C. auris and bacterial MDROs in healthcare settings.

6.
Infect Control Hosp Epidemiol ; 44(11): 1834-1839, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37990904

ABSTRACT

OBJECTIVE: Quantify the frequency and drivers of unreported coronavirus disease 2019 (COVID-19) symptoms among nursing home (NH) staff. DESIGN: Confidential telephone survey. SETTING: The study was conducted in 70 NHs in Orange County, California, December 2020-February 2022. PARTICIPANTS: The study included 120 NH staff with COVID-19. METHODS: We designed a 40-item telephone survey of NH staff to assess COVID-19 symptom reporting behavior and types of barriers [monetary, logistic, and emotional (fear or stigma)] and facilitators of symptom reporting using 5-point Likert scales. Summary statistics, reliability of survey constructs, and construct and discriminant validity were assessed. RESULTS: Overall, 49% of surveys were completed during the 2020-2021 COVID-19 winter wave and 51% were completed during severe acute respiratory coronavirus virus 2 (SARS-CoV-2) δ (delta)/ (omicron) waves, with a relatively even distribution of certified nursing assistants, licensed vocational or registered nurses, and nonfrontline staff. Most COVID-19 cases (71%) were detected during mandated weekly NH surveillance testing and most staff (67%) had ≥1 symptom prior to their test. Only 34% of those with symptoms disclosed their symptom to a supervisor. Responses were consistent across 8 discrete survey constructs with Cronbach α > 0.70. In the first wave of the pandemic, fear and lack of knowledge were drivers of symptom reporting. In later waves, adequate staffing and sick days were drivers of symptom reporting. COVID-19 help lines and encouragement from supervisors facilitated symptom reporting and testing. CONCLUSIONS: Mandatory COVID-19 testing for NH staff is key to identifying staff COVID-19 cases due to reluctance to speak up about existing symptoms. Active encouragement from supervisors to report symptoms and stay home when ill was a major driver of symptom reporting and resultant infection prevention and worker safety measures.


Subject(s)
COVID-19 , Humans , COVID-19/diagnosis , COVID-19/epidemiology , COVID-19 Testing , SARS-CoV-2 , Reproducibility of Results , Nursing Homes
7.
N Engl J Med ; 389(19): 1766-1777, 2023 Nov 09.
Article in English | MEDLINE | ID: mdl-37815935

ABSTRACT

BACKGROUND: Nursing home residents are at high risk for infection, hospitalization, and colonization with multidrug-resistant organisms. METHODS: We performed a cluster-randomized trial of universal decolonization as compared with routine-care bathing in nursing homes. The trial included an 18-month baseline period and an 18-month intervention period. Decolonization entailed the use of chlorhexidine for all routine bathing and showering and administration of nasal povidone-iodine twice daily for the first 5 days after admission and then twice daily for 5 days every other week. The primary outcome was transfer to a hospital due to infection. The secondary outcome was transfer to a hospital for any reason. An intention-to-treat (as-assigned) difference-in-differences analysis was performed for each outcome with the use of generalized linear mixed models to compare the intervention period with the baseline period across trial groups. RESULTS: Data were obtained from 28 nursing homes with a total of 28,956 residents. Among the transfers to a hospital in the routine-care group, 62.2% (the mean across facilities) were due to infection during the baseline period and 62.6% were due to infection during the intervention period (risk ratio, 1.00; 95% confidence interval [CI], 0.96 to 1.04). The corresponding values in the decolonization group were 62.9% and 52.2% (risk ratio, 0.83; 95% CI, 0.79 to 0.88), for a difference in risk ratio, as compared with routine care, of 16.6% (95% CI, 11.0 to 21.8; P<0.001). Among the discharges from the nursing home in the routine-care group, transfer to a hospital for any reason accounted for 36.6% during the baseline period and for 39.2% during the intervention period (risk ratio, 1.08; 95% CI, 1.04 to 1.12). The corresponding values in the decolonization group were 35.5% and 32.4% (risk ratio, 0.92; 95% CI, 0.88 to 0.96), for a difference in risk ratio, as compared with routine care, of 14.6% (95% CI, 9.7 to 19.2). The number needed to treat was 9.7 to prevent one infection-related hospitalization and 8.9 to prevent one hospitalization for any reason. CONCLUSIONS: In nursing homes, universal decolonization with chlorhexidine and nasal iodophor led to a significantly lower risk of transfer to a hospital due to infection than routine care. (Funded by the Agency for Healthcare Research and Quality; Protect ClinicalTrials.gov number, NCT03118232.).


Subject(s)
Anti-Infective Agents, Local , Asymptomatic Infections , Chlorhexidine , Cross Infection , Nursing Homes , Povidone-Iodine , Humans , Administration, Cutaneous , Administration, Intranasal , Anti-Infective Agents, Local/administration & dosage , Anti-Infective Agents, Local/therapeutic use , Baths , Chlorhexidine/administration & dosage , Chlorhexidine/therapeutic use , Cross Infection/epidemiology , Cross Infection/prevention & control , Cross Infection/therapy , Hospitalization/statistics & numerical data , Nursing Homes/statistics & numerical data , Patient Transfer/statistics & numerical data , Povidone-Iodine/administration & dosage , Povidone-Iodine/therapeutic use , Skin Care/methods , Asymptomatic Infections/therapy
9.
Infect Control Hosp Epidemiol ; 44(9): 1490-1493, 2023 09.
Article in English | MEDLINE | ID: mdl-37325907

ABSTRACT

Standardized observation of bed baths and showers for 100 residents in 8 nursing homes revealed inadequate cleansing of body sites (88%-100% failure) and >90% process failure involving lather, firm massage, changing dirty wipes or cloths, and following clean-to-dirty sequence. Insufficient water warmth affected 86% of bathing opportunities. Bathing training and adequate resources are needed.


Subject(s)
Baths , Nursing Homes , Humans , Skilled Nursing Facilities
10.
Infect Control Hosp Epidemiol ; 44(9): 1508-1510, 2023 09.
Article in English | MEDLINE | ID: mdl-36756757

ABSTRACT

Persons with Alzheimer's disease and related dementias (ADRD) are prone to receiving reduced quality of care. We compared the quality of room cleaning of rooms with ADRD residents and rooms with non-ADRD residents in nursing homes using an ultraviolet (UV) marker. ADRD status was associated with greater failure of UV marker removal (odds ratio, 1.68; 95% confidence interval, 1.04-2.71; P = .03).


Subject(s)
Alzheimer Disease , Humans , Nursing Homes
11.
Microbiol Spectr ; : e0388022, 2023 Feb 01.
Article in English | MEDLINE | ID: mdl-36722961

ABSTRACT

Pooling of samples can increase throughput and reduce costs for large-scale SARS-CoV-2 testing when incidence is low. In a cross-sectional study of serial SARS-CoV-2 sampling of staff and residents at three nursing homes, laboratory labor constraints limited the feasibility of pooling prior to the maximal incidence that favored cost savings. IMPORTANCE This study highlights the pragmatic considerations surrounding SARS-CoV-2 sample pooling beyond accuracy and costs. We performed a cost analysis to determine the percent positivity at which pooling would reduce costs versus single testing. We found that the need for a stable amount of daily work hours staffed by a highly trained workforce was a major limitation in pooling as test positivity increased. For the COVID-19 pandemic and future pandemic threats, laboratories should carefully consider the thresholds at which sample pooling is beneficial, with a particular focus on the impact on laboratory staff.

12.
Infect Control Hosp Epidemiol ; 44(2): 315-318, 2023 02.
Article in English | MEDLINE | ID: mdl-34913422

ABSTRACT

The CLEAR Trial recently found that decolonization reduced infections and hospitalizations in MRSA carriers in the year following hospital discharge. In this secondary analysis, we explored whether decolonization had a similar benefit in the subgroup of trial participants who harbored USA300, using two different definitions for the USA300 strain-type.


Subject(s)
Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Humans , Aftercare , Carrier State/drug therapy , Patient Discharge , Staphylococcal Infections/drug therapy , Staphylococcal Infections/prevention & control
13.
Clin Infect Dis ; 76(3): e1208-e1216, 2023 02 08.
Article in English | MEDLINE | ID: mdl-35640877

ABSTRACT

BACKGROUND: The CLEAR Trial demonstrated that a multisite body decolonization regimen reduced post-discharge infection and hospitalization in methicillin-resistant Staphylococcus aureus (MRSA) carriers. Here, we describe decolonization efficacy. METHODS: We performed a large, multicenter, randomized clinical trial of MRSA decolonization among adult patients after hospital discharge with MRSA infection or colonization. Participants were randomized 1:1 to either MRSA prevention education or education plus decolonization with topical chlorhexidine, oral chlorhexidine, and nasal mupirocin. Participants were swabbed in the nares, throat, axilla/groin, and wound (if applicable) at baseline and 1, 3, 6, and 9 months after randomization. The primary outcomes of this study are follow-up colonization differences between groups. RESULTS: Among 2121 participants, 1058 were randomized to decolonization. By 1 month, MRSA colonization was lower in the decolonization group compared with the education-only group (odds ration [OR] = 0.44; 95% confidence interval [CI], .36-.54; P ≤ .001). A similar magnitude of reduction was seen in the nares (OR = 0.34; 95% CI, .27-.42; P < .001), throat (OR = 0.55; 95% CI, .42-.73; P < .001), and axilla/groin (OR = 0.57; 95% CI, .43-.75; P < .001). These differences persisted through month 9 except at the wound site, which had a relatively small sample size. Higher regimen adherence was associated with lower MRSA colonization (P ≤ .01). CONCLUSIONS: In a randomized, clinical trial, a repeated post-discharge decolonization regimen for MRSA carriers reduced MRSA colonization overall and at multiple body sites. Higher treatment adherence was associated with greater reductions in MRSA colonization.


Subject(s)
Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Adult , Humans , Mupirocin/therapeutic use , Chlorhexidine/therapeutic use , Anti-Bacterial Agents/therapeutic use , Anti-Bacterial Agents/pharmacology , Patient Discharge , Aftercare , Staphylococcal Infections/drug therapy , Staphylococcal Infections/prevention & control , Carrier State/drug therapy , Carrier State/prevention & control , Drug Resistance, Microbial , Hospitals
15.
Am J Infect Control ; 51(7): 841-843, 2023 07.
Article in English | MEDLINE | ID: mdl-36403708

ABSTRACT

We hosted a confidential helpline to address concerns about COVID-19 prevention among staff in 12 nursing homes in Orange County, California. We fielded 301 inquiries from April 2021-April 2022, most commonly involving questions about vaccines (40%), nursing home COVID-19 prevention (28%), SARS-CoV-2 variants (18%), symptom reporting (10%), and home and community COVID-19 prevention (5%). During COVID-19 surges, staff dominantly expressed fear, anger, and exhaustion. During nadirs, sentiment shifted towards optimism and acceptance.


Subject(s)
COVID-19 , Humans , COVID-19/prevention & control , SARS-CoV-2 , Nursing Homes , Skilled Nursing Facilities
17.
Infect Control Hosp Epidemiol ; 43(12): 1937-1939, 2022 12.
Article in English | MEDLINE | ID: mdl-34433509

ABSTRACT

In a prospective cohort study, we compared a 2-swabs-per-nostril 5% iodophor regimen with a 1-swab-per-nostril 10% iodophor regimen on methicillin-resistant Staphylococcus aureus carriage in nursing-home residents. Compared with baseline, both single-swab and double-swab regimens resulted in an identical 40% reduction in nasal carriage and 60% reduction in any carriage, skin or nasal.


Subject(s)
Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Humans , Chlorhexidine/pharmacology , Staphylococcal Infections/prevention & control , Staphylococcus aureus , Prospective Studies , Iodophors
18.
Cureus ; 13(6): e16011, 2021 Jun.
Article in English | MEDLINE | ID: mdl-34336501

ABSTRACT

INTRODUCTION: Morphometric differences of several bones form the basis of sexual differentiation. The mastoid triangle has been widely used as a predictor of sexual differentiation. However, the radiographic measurements of the mastoid triangle, which form the clinical alternative of this parameter, have not been studied in the North Indian population. Therefore, we analyzed skull radiographs of live subjects to investigate the effectiveness of the radiographic mastoid triangle in sex determination. METHODS: One hundred skull lateral radiographs (55 male and 45 female) from the digital archives of a tertiary care teaching institute in Northern India were retrospectively analyzed. The following parameters: porion-mastoidale length, mastoidale-asterion length, asterion-porion length, and area of the mastoid triangle were measured. Gender-based differences for these parameters were then calculated for any statistical significance. Further, the low value of Wilks' lambda, high values of Eigenvalues, and percentage of correct prediction accuracy denoted higher predictive value. Finally, discriminant function analysis was used to predict the relative validity of each measured parameter. RESULT: All measured parameters were significantly higher in the male group. The porion-mastoidale length was 32.21±2.15 mm in males and 31.66±3.21 mm in females. The mastoidale-asterion length was 50.00±9.75 mm in males and 49.84±6.97 in females. The asterion-porion length was 44.11±6.82 mm in males and 39.72±5.77 mm in females. The area of the mastoid triangle was 690.74±123.35 mm2 in males and 570.57±130.0 mm2 in females. The area of the mastoid triangle has the highest relative validity (78%). CONCLUSION: Considerable ethnic and racial differences have been observed in the radiographic morphology of the mastoid. The radiographic dimensions of the mastoid are potential predictors of sexual dimorphism. With the use of discriminant function analysis, the current study predicts the effectiveness of the area of the mastoid triangle as a reliable parameter for sexual differentiation in the Northern Indian population.

20.
Cerebrovasc Dis ; 50(2): 162-170, 2021.
Article in English | MEDLINE | ID: mdl-33472192

ABSTRACT

BACKGROUND: While endovascular stroke treatment (EST) of large vessel occlusions in acute ischemic stroke (AIS) is proven to be safe and effective, there are subgroups of patients with increased rates of hemorrhages. Our goal was to identify risk factors for intracerebral hemorrhage and to assess whether acute carotid artery stenting (CAS) was associated with increased bleeding rates. METHODS: We performed a retrospective analysis of our monocentric prospective stroke registry in the period from May 2010 to May 2018 and compared AIS patients receiving EST with (n = 73) versus without acute CAS (n = 548). Patients with intracranial stents, intra-arterial thrombolysis, or dissection of the carotid artery were excluded. RESULTS: Parenchymal hemorrhage rates (PH2 according to the ECASS classification) and symptomatic hemorrhage (sICH) rates were increased in EST patients receiving CAS with odds being 6.3 (PH2) and 6.5 (sICH) times higher (PH2 17.8 vs. 3.3%, p < 0.001 and sICH: 16.4 vs. 2.9%, p < 0.001). Additional systemic thrombolysis with rtPA (IVRTPA) was no risk factor for cerebral hemorrhage (p = 0.213). CONCLUSION: AIS patients receiving EST with acute CAS and consecutive tirofiban or dual antiplatelet therapy suffered from an increased risk of relevant secondary intracranial bleeding. After adjusting for confounders, tirofiban and dual antiplatelet therapy were associated with higher bleeding rates.


Subject(s)
Carotid Stenosis/therapy , Cerebral Hemorrhage/chemically induced , Dual Anti-Platelet Therapy/adverse effects , Endovascular Procedures , Platelet Aggregation Inhibitors/adverse effects , Stroke/therapy , Thrombectomy , Thrombolytic Therapy , Aged , Aged, 80 and over , Carotid Stenosis/diagnostic imaging , Cerebral Hemorrhage/diagnostic imaging , Emergencies , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Female , Humans , Male , Middle Aged , Registries , Retrospective Studies , Risk Assessment , Risk Factors , Stents , Stroke/diagnostic imaging , Thrombectomy/adverse effects , Thrombolytic Therapy/adverse effects , Time Factors , Tirofiban/adverse effects , Treatment Outcome
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