1.
Br J Hosp Med (Lond)
; 77(7): 403-8, 2016 Jul.
Article
in English
| MEDLINE
| ID: mdl-27388379
ABSTRACT
Among proposed mechanisms to explain digital clubbing, the release of cytokines, specifically vascular endothelial growth factor and platelet-derived growth factor, from aggregated platelets and megakaryocytes has emerged as the most likely explanation. This review describes these and other contributory processes.
Subject(s)
Cytokines/metabolism , Hemiplegia/physiopathology , Hypoxia/physiopathology , Intercellular Signaling Peptides and Proteins/metabolism , Osteoarthropathy, Primary Hypertrophic/physiopathology , Osteoarthropathy, Secondary Hypertrophic/physiopathology , Bradykinin/metabolism , Epidermal Growth Factor/metabolism , Ferritins/metabolism , Hemiplegia/complications , Hemiplegia/metabolism , Hepatocyte Growth Factor/metabolism , Human Growth Hormone/metabolism , Humans , Hypoxia/complications , Hypoxia/metabolism , Interleukin-6/metabolism , Osteoarthropathy, Primary Hypertrophic/metabolism , Osteoarthropathy, Secondary Hypertrophic/etiology , Osteoarthropathy, Secondary Hypertrophic/metabolism , Platelet-Derived Growth Factor/metabolism , Prostaglandins/metabolism , Serotonin/metabolism , Transforming Growth Factor beta1/metabolism , Tumor Necrosis Factor-alpha/metabolism , Vascular Endothelial Growth Factor A/metabolism , von Willebrand Factor/metabolism
2.
Br J Hosp Med (Lond)
; 77(6): 368-9, 2016 Jun.
Article
in English
| MEDLINE
| ID: mdl-27269757
Subject(s)
Autoantibodies/immunology , Autoimmune Diseases/immunology , Dizziness/immunology , Myocardial Infarction/immunology , Potassium Channels, Voltage-Gated/immunology , Syncope/immunology , Aged , Autoimmune Diseases/complications , Autoimmune Diseases/diagnosis , Dizziness/etiology , Humans , Male , Myocardial Infarction/etiology , Syncope/etiology , Syndrome
3.
BMJ Case Rep
; 20162016 Jan 20.
Article
in English
| MEDLINE
| ID: mdl-26791129
ABSTRACT
A young woman presented with general malaise in relation to the metabolic condition ornithine transcarbamylase deficiency. Her ammonia level had risen to 229â µmol/L (normal range 0-59â µmol/L). She was treated using her emergency pack of intravenous medicines and made a complete response. We briefly discuss the need to make an urgent diagnosis, the 'mechanism' for checking serum ammonia levels and therapies.
