ABSTRACT
Pooling data across diverse sources acquired by multisite consortia requires compliance with a predefined reference protocol i.e., ensuring different sites and scanners for a given project have used identical or compatible MR physics parameter values. Traditionally, this has been an arduous and manual process due to difficulties in working with the complicated DICOM standard and lack of resources allocated towards protocol compliance. Moreover, issues of protocol compliance is often overlooked for lack of realization that parameter values are routinely improvised/modified locally at various sites. The inconsistencies in acquisition protocols can reduce SNR, statistical power, and in the worst case, may invalidate the results altogether. An open-source tool, mrQA was developed to automatically assess protocol compliance on standard dataset formats such as DICOM and BIDS, and to study the patterns of non-compliance in over 20 open neuroimaging datasets, including the large ABCD study. The results demonstrate that the lack of compliance is rather pervasive. The frequent sources of non-compliance include but are not limited to deviations in Repetition Time, Echo Time, Flip Angle, and Phase Encoding Direction. It was also observed that GE and Philips scanners exhibited higher rates of non-compliance relative to the Siemens scanners in the ABCD dataset. Continuous monitoring for protocol compliance is strongly recommended before any pre/post-processing, ideally right after the acquisition, to avoid the silent propagation of severe/subtle issues. Although, this study focuses on neuroimaging datasets, the proposed tool mrQA can work with any DICOM-based datasets.
ABSTRACT
STATEMENT OF PROBLEM: The conventional diagnostic mounting procedure in completely edentulous patients is time-consuming and increases the laboratory workload. Alternatives like optical scanners and jaw tracking devices have been documented but have their own shortcomings. PURPOSE: The purpose of this pilot clinical study was to assess the suitability of an infrared sensor scan device in procuring the diagnostic data parameters for completely edentulous patients. MATERIAL AND METHODS: Twelve completely edentulous participants were enrolled in the study. For each, the distance between the arches was measured by 2 clinical techniques at 3 common reference points, M1, M2, M3, for the maxillary arch and m1, m2, m3 for the mandibular arch. The control group measurements were recorded by using a standard diagnostic mounting procedure on a semi-adjustable articulator, and the experimental group measurements were recorded by using an infrared sensor scan device. To convert the analog infrared sensor output into digital data, the Arduino ADC software program was used. The data from both study groups were statistically compared by using the independent t test (α=.05). RESULTS: No significant difference in variation was found between the mean measurements of the device and diagnostic mounting (P>.05). The maximum variation recorded by the experimental device was 1.7 mm, whereas the minimum variation was 0.8 mm (mean 1.25 mm). CONCLUSIONS: The use of precisely calibrated infrared sensors may be a cost-effective option for diagnostic mounting.
ABSTRACT
BACKGROUND: Dental shade guides are used before restorative and prosthodontic procedures for the evaluation of tooth color. The spectral coverage of the specific shaded guide and a clinician's experience in shade matching are the two most important factors for a clinically viable shade match of the restoration to the given tooth. Repeated disinfection of the shade guide with disinfectant lead to a clinically significant difference of the shade to be matched, finally resulting in a clinically unacceptable prosthesis. The purpose of this study is to evaluate the effects of disinfection on various shade tabs of VITA 3D Master Shade guide after being subjected to 2 years of simulated disinfection with 70% isopropyl alcohol. METHODOLOGY: Two sets of VITA 3-D Master Shade Guides were used. One set of each shade guide was assessed after simulated use and surface disinfection with 70% isopropyl alcohol (test group), while the other full set was subjected to cleansing with distilled water (control group). Spectrophotometer was used to measure each of the shade tabs. Readings were recorded at regular intervals of 120, 240, 360, 480, 600, 720, 840, and 960 disinfection cycles. The ΔE values obtained were used to examine the color difference. RESULTS: There was a significant difference in terms of ΔE between the shade tabs of control and test groups of VITA 3D Master shade guides after 960 cycles of disinfection. The change in mean ΔE was more in the test specimens in the shade tabs of VITA 3D Master Shade Guide tabs than the control specimens. These results are of statistical significance, but they might not be of any clinical significance. CONCLUSION: There was a statistically significant but clinically nonsignificant color change in the shade tabs of VITA 3D Master shade guides after 2 years of simulated use and disinfection with 70% isopropyl alcohol.
ABSTRACT
Phospholipase A1 (PLA1) immobilized in calcium alginate can effectively overcome the mass transfer resistance at the lipid-water interface making more room for the enzyme to separate itself from the products of reaction and to bind with the next available molecule at the interface. The reaction of an immobilized PLA1 hydrolase from Thermomyces lanuginosus was comparatively faster than of its free form. The rate of phospholipid hydrolysis by PLA1 was studied in calcium-rich and calcium-depleted environments; and the extent of phosphorus removed from the crude rice bran oil as well as the amount of free fatty acids produced during the reaction were used as indices for analysing the rate of enzymatic hydrolysis under standard conditions of pH, temperature, time of incubation and agitation. The immobilized PLA1 was found to be superior in removing phosphorus in the presence of 10 mM bivalent calcium ions in a solution. As compared to a maximum of 72.52% phosphorus removed by 0.01 kg of free enzyme per kg of oil, the same amount of immobilized PLA1 removed phosphorus from oil by 94.12% under the same experimental conditions (pH=6, 60 °C, 1-hour incubation). Both the free PLA1 and its immobilized form had shown extended rates of hydrolysis in a calcium-rich environment. The mass fractions of free fatty acids produced by the free enzyme and by its immobilized form were 14.9 and 14.16%, respectively, under the above experimental conditions. The removal of phosphorus from oil was accompanied by a significant reduction in colour and restoration of iodine value to the desired level.
