ABSTRACT
AIM: We report a case of fulminant hepatitis and glomerulonephritis by Hepatitis A virus infection. METHODS: We observed the patient's clinical course and analyzed his data retrospectively. RESULTS: The three-year-old boy presented with features of acute renal failure and stage 2 hepatic encephalopathy. Renal biopsy showed diffuse mesangioproliferative glomerulonephritis with immunoglobulin M and complement 3 deposition. After receiving supportive treatment for over 6 weeks, the hepatic and renal function became normal. Renal biopsy after 3 months was normal. CONCLUSION: Acute renal failure is a rare complication of Hepatitis A virus infection. Physicians should be aware of the potential renal involvement of Hepatitis A virus infection as the prognosis is not always favourable.
Subject(s)
Glomerulonephritis, Membranoproliferative/etiology , Hepatic Encephalopathy/etiology , Hepatitis A/complications , Liver/pathology , Child, Preschool , Complement C3/metabolism , Glomerulonephritis, Membranoproliferative/diagnosis , Glomerulonephritis, Membranoproliferative/therapy , Hepatic Encephalopathy/diagnosis , Hepatic Encephalopathy/therapy , Hepatitis A/diagnosis , Hepatitis A/therapy , Hepatitis A Virus, Human/isolation & purification , Humans , Immunoglobulin M/immunology , Male , Retrospective StudiesABSTRACT
OBJECTIVE: The study was conducted to find out whether there is any significant difference in outcome if low birth weight babies weighing between 1500g and 1800g are managed by keeping them with their mothers, i.e., without special care neonatal unit (SCNU) admission. METHODS: It was a retrospective study for which data was collected from past medical record section of 6 months duration from 01.07.06 to 31.12.06, Medical College, Kolkata. The subject of the study was babies born with weight between 1500g and 2000g, divided into 2 groups. Group A representing babies born between weight 1500g and 1800g, groups B representing babies born between 1801g and 2000g. The groups were compared with regard to four variable namely average material age, sex of the babies, singleton or twin pregnancy, mode of delivery and gestational maturity. Test of one proportion was used for statistical analysis of outcome. RESULTS: Total number of live born babies in group A were 198 and in group B 223. Two group were comparable with respect to average maternal age (23.7 yr), sex distribution, singleton or twin pregnancy and number of cesarian section or vaginal delivery and proportion of small for gestational age (SGA) babies. In both the group 13 babies required SCNU admission after being given to their mothers in the postnatal ward. No significant difference in outcome was observed between the groups. CONCLUSION: We conclude that the recommended guidelines for giving institutional care to babies below 1800g may be lowered down to 1500g. However, more babies should be evaluated prospectively, over a longer duration of time, before changing the standard guidelines.
Subject(s)
Birth Weight , Infant, Very Low Birth Weight , Intensive Care Units, Neonatal/statistics & numerical data , Adult , Female , Guideline Adherence , Humans , India , Infant, Newborn , Infant, Small for Gestational Age , Male , Maternal Age , Practice Guidelines as Topic , Pregnancy , Pregnancy Outcome , Pregnancy, Multiple , Retrospective Studies , Risk FactorsABSTRACT
A newborn presented with erythematous lesion over face, which appeared soon after birth. Diagnosis of neonatal lupus erythematosus (NLE) was confirmed by positive anti-Ro SSA antibody and skin biopsy. But anti-La SSB antibody was negative. Her hepatic transaminases were high. But no cardiac manifestations were noted.
Subject(s)
Antibodies, Antinuclear/immunology , Lupus Erythematosus, Cutaneous/diagnosis , Ribonucleoproteins/immunology , Diagnosis, Differential , Face , Female , Humans , Infant, Newborn , Lupus Erythematosus, Cutaneous/immunology , PrognosisABSTRACT
The Mohr-Claussen syndrome or oro-facial-digital syndrome type II (OFD-II)] is characterised by tongue lobulation, midline cleft lip, high arched or cleft palate, broad nasal root with wide bifid nasal tip, hypertelorism, micrognathia, brachydactyly, syndactyly and polydactyly, bilateral reduplicated hallux, conductive hearing loss and normal intelligence. In view of the different modes of inheritance and the different prognoses of the two oro-facio-digital syndromes, type 1 and type 2, it is important to establish a correct diagnosis in these patients. A neonate with features of oro-facio-digital syndrome, type-II is being reported and the distinguishing clinicoradiological features with type-I are compared.
