ABSTRACT
AIM: Cognitive deficits have been presupposed to be endophenotypic markers in bipolar disorder, but few studies have ascertained the cognitive deficits in healthy relatives of bipolar disorder patients. The aim of the present study was to assess the cognitive functions of first-degree relatives of patients with bipolar disorder and compare them with healthy controls. METHODS: Ten first-degree apparently healthy relatives of patients with bipolar disorder were compared with 10 age- and education-matched control subjects on computer-based cognitive tests. RESULTS: As compared to the control group, the relatives group performed significantly poorly on tests for executive function and vigilance, while on the test for working memory the performance was not significantly different on most of the parameters. CONCLUSIONS: Executive functioning and vigilance could be potential markers of the endophenotype in bipolar patients.
Subject(s)
Bipolar Disorder/genetics , Cognition Disorders/genetics , Neuropsychological Tests/statistics & numerical data , Adult , Attention , Bipolar Disorder/diagnosis , Bipolar Disorder/psychology , Case-Control Studies , Cognition Disorders/diagnosis , Cognition Disorders/psychology , Discrimination Learning , Female , Humans , Male , Memory, Short-Term , Orientation , Pattern Recognition, Visual , Phenotype , Problem Solving , Psychometrics , Psychomotor Performance , Reference Values , SiblingsABSTRACT
This study investigated maxillary and mandibular growth differences and their effect on the changes in molar relationships from early transitional dentition to adult permanent dentition. Various landmarks were identified and measurements made on the longitudinal cephalometric radiographs of 40 people. The subjects were classified into 3 groups based on the amount of sagittal skeletal growth difference between the jaws. In group A, the mandible grew more than did the maxilla; in Group B, growth was about the same; and in group C, the maxilla grew more than did the mandible. The results revealed that skeletal growth differences between the jaws significantly influenced the changes in molar relationship during the transitional dentition, not only by translating basal bones but also by altering the amount of physiologic mesial shift in the dentition. However, the skeletal growth difference during the permanent dentition did not influence the changes in molar relationship. The sagittal growth difference between the jaws was largely absorbed by a dentoalveolar compensation. Tooth movement showed different characteristic features depending on the amount of the skeletal growth difference: (1) If the mandible grew more than did the maxilla, the growth difference was mostly absorbed by mesial displacement of the maxillary first molars and counterclockwise rotation of the occlusal plane. Anterior occlusion was adjusted by mesial displacement and labial inclination of the maxillary incisors and lingual inclination of the mandibular incisors. (2) If the maxilla grew more than did the mandible, the growth difference was mainly absorbed by mesial displacement of the mandibular molars. Then the maxillary molars showed minimal mesial displacement. The occlusal plane also showed minimal rotational change. Anterior occlusion was adjusted by lingual tipping of the maxillary incisors and mesial displacement and labial tipping of the mandibular incisors.
