Computational and spectral analysis of derivatives of 9,9-dimethyl-9,10-dihydroacridine and 10-Phenyl-10H-phenothiazine-5,5-dioxide with hybridized local and charge-transfer excited states for optoelectronic applications.

Aiming to combine the advantages of both prompt fluorescence and thermally activated delayed fluorescence in single emitter, molecular design of emitters with hybridized locally excited and charge transfer states were investigated by computational approaches and optical spectroscopy. Taking into account the results of the theoretical screening, the most promising derivatives of 9,9-dimethyl-9,10-dihydroacridine and 10-phenyl-10H-phenothiazine-5,5-dioxide based with the different linking topology (meta- and para-isomers) were selected for the synthesis and experimental investigations. Both the compounds exhibit ultraviolet LE emission peaking at ca. 360 nm, green ICT peaking at ca. 510 nm, and deep-blue HLCT emission peaking at ca. 430 nm when they are molecularly dispersed in the solid media of the different polarity. The developed emitters allow to obtain deep-blue electroluminescence for the host-containing OLEDs and green electroluminescence of host-free devices with the efficiency of exciton production of 42 and 73%, respectively. Efficient exciton production is due to the spin-flip switching via thermally activated processes which is much more efficient than prompt fluorescence. Showing the impact of the linking topology, the para-isomer demonstrated more efficient triplet harvesting in OLEDs than meta-isomer. A detailed discussion on the structure-property relationships and on some discrepancies between the results of the results of theoretical calculations and spectral analysis allows to obtain important insights on the photophysical properties of these compounds.

[Minimally invasive surgery and neoplasms of the inferior third of the rectum: personal technique]. / Chirurgia miniinvasiva e neoplasie del terzo inferiore del retto: tecnica personale.

In the last decade minimally invasive surgery has gained an increasing success and was firstly applied to the treatment of benign pathologies, and recently to the malignant ones. The Authors report two cases of inferior rectal neoplasm treated with Miles operation through a video-laparoscopic-perineal approach. The abdominal phase of the operation was performed only through 5 small laparoscopic incisions. The perineal phase and the stoma were performed using traditional technique. The method appears feasible and oncologically correct; however, further trials are needed to evaluate long-term results.

[Sutures without sutures in digestive surgery. Experimental study of the rat intestine]. / Suture senza suture in chirurgia digestiva. Studio sperimentale sull'intestino del ratto.

The aim of the experimental study was to evaluate the possibility of performing an end-to-end anastomosis by using fibrin adhesive as the only means of suture. To this end, 24 Wistar rats were used, of which 16 underwent ilear resection and 8 underwent colotomy, and they were divided respectively into two groups. On the rats of the first group the anastomosis was performed by using only fibrin adhesive; on the rats of the second group operated the anastomosis was performed by using fibrin adhesive in association with non adsorbable suture material, while on those operated of colectomy the anastomosis was performed by fibrin adhesive and adsorbable suture material. The anatomo-phatological studies on the anastomosis have shown a similar healing process in the cases treated only with fibrin adhesive and by using absorbable material and has demonstrated the trange material from the suture, which are a possible causes of complication.

[Laparoscopic cholecystectomy. Our experience]. / La colecistectomia laparoscopica. Nostra esperienza.

This study analysed 90 cases of symptomatic cholelithiasis treated with laparoscopic cholecystectomy. 27% of the cases studied suffered from microlithiasis, 44% from multiple calculosis with calculi measuring 1 to 2 cm in diameter, 25% from single calculi measuring up to 4 cm in diameter, and 4% from a benign proliferative pathology of the cholecystic wall. Calculosis of the main biliary tract was also found in 3 patients and was treated by preoperative endoscopic papillosphincterotomy. In addition to routine tests and ultrasonography, endovenous cholangiography, or retrograde cholangiography (ERCP) in cases of suspected calculosis of the biliary tract, was always performed prior to surgery. Mean operating time was 60 min. Two procedures were converted into laparotomy due to laceration of the cystic artery. In one case laparotomy was performed on day two due to choleperitoneum following a lesion of the cystic duct. Pneumoperitoneum could not be performed in three cases. Mean hospital stay was 48 hours. No other intra- or postoperative complications were reported. These results support the opinion that laparoscopic cholecystectomy is a safe method, with few limitations and represents the treatment of choice in the therapy of symptomatic cholelithiasis.

Prediction of pulmonary immunodeficiency in chronic bronchitis by cutaneous hypoergy to multitest.

Multitest (Pasteur Mérieux) is a plastic disposable device used to assess delayed cutaneous hypersensitivity (DCH) to seven antigens. Hypoergy to Multitest is believed to reflect a status of compromised cell-mediated immunity. Among the many possible pathogenic factors of chronic bronchitis, immunodepression has been little investigated. Indeed, whether lower immunodefence is the cause or the consequence of chronic bronchitis is still a subject of debate. The aim of the study was to evaluate DCH in a large group of patients with chronic obstructive pulmonary disease (COPD) and in a control group, in order to relate DCH (expressed as score, mm) to clinical and functional impairment. One hundred patients with COPD in stable conditions and not undergoing treatment with immunomodulating drugs (mean age, yr, M +/- SD: 66.1 +/- 6.5) and 40 normal controls in the same age range were admitted to the study. Evaluated parameters were: symptoms scores, physical examination, lung function tests and Multitest. Fifty-three percent of the COPD patients were hypoergic compared with 14% of controls. The Multitest score was 10 +/- 10 (mm M +/- SD) in COPD compared with 17 +/- 9 in controls. The Multitest score was significantly related to age (r = -0.45) in the control group, but not in COPD patients. DCH to only three of the seven antigens may predict a response to Multitest, with a sensitivity of 90%.(ABSTRACT TRUNCATED AT 250 WORDS)