[Hypersensitivity reactions to antilipemic drugs]. / Reactii de hipersensibilizare ale medicatiei hipolipemiante.

Chronic utilization of hipolipemiants drugs makes possible the onset of hypersensitivity reactions like a part of secondary reactions. From the point of our experience the most frequent hyperreactivity appears on fibric acid derivates. Al the cases we treated, were skin manifestations (angioedema) and about 29%, were digestive manifestations (dyspepsia, vomiting, diarrhoea). At the same time, chronic utilization of nicotinic acid derivates favored skin rash due to congestive intrinsic effect of nicotinic acid.

[The bronchial asthma-gastroesophageal reflux association]. / Asocierea astm bronsic--reflux gastroesofagian.

The gastroesophageal reflux acts as a trigger mechanism in the induction of a asthmatic attack, either as an aggravating or a releasing factor. Our study was underwent on 15 out of 100 followed up asthmatic patients who did not respond to the usual treatments and demonstrated the usual treatments and demonstrated the intervention of the gastroesophageal reflux. Its presence was suggested clinically by the symptoms (pyrosis, dysphagia, acid regurgitations) and confirmed in 5 patients by the barium examination in Trendelenburg and in the remainder of 10 by the esophageal pH, determination of gastroesophageal motility and endoscopic examination. Excepting the known allergenic conditions, the attacks were recorded during night or postprandially, being usually preceded by the above mentioned symptoms. The antispastic and antisecretory treatment improved the respiratory symptoms. The recognition of this association, i.e. bronchial asthma-gastroesophageal reflux, has a practical importance, the intervention of the esophageal component leading to the termination of the attacks.

[Bronchial asthma in old people]. / Astmul bronsic la batrîni.

Bronchial asthma in old people is defined, according to a number of Anglo-Saxon authors, as a disease which occurs for the first time (de novo) at an advanced age (i.e. over 70 years). The present follow-up study had been carried out in the Diagnostic Division of the Outpatient Department--Polyclinic no. 1 of Iasi--and has in view only the patients who had the first attack of disease at the time they were over 60. Clinical examination was complemented by the following tests: spirography, X-ray, allergological cutaneous tests, and test for the identification of eosinophils in sputum. A certain pattern was identified: the first asthmatic symptoms followed rhinobronchial episodes persistent spasmodic cough and continuous dyspnea induced by effort were frequent complaints; typical crises were uncommon. The allergic aetiology was supported by a positive anamnesis, while the cutaneous tests confirmed the presence of an allergen in only 20% of the cases; chronic and recurrent infections were present in 85% of the cases. At the same time, the presence of gastroesophageal reflux was searched as its frequency in the elderly as well as its role in inducing the bronchial asthma have often been reported. It is expected the identification of the characteristic pattern might lead to a correct diagnosis of bronchial asthma in old people and contribute to better therapy.