[Use of hemostasis in repeat operations in phthisiopulmonology patients]. / Izmenenie gemostaza pri povtornykh operatsiiakh u ftiziopul'monologicheskikh bol'nykh.

Blood coagulative parameters were studied in 14 patients at resurgery for complicated forms of pulmonary tuberculosis. The hypocoagulative syndrome due to changes in all hemostatic links: (vascular thrombocytic, coagulative, and fibrinolytic), was detected in the early postoperative period. These changes compensated on postoperative day 3. On day 7 after surgery the hemostatic parameters returned to the preoperative value. Principles of correction of hemocoagulative disorders are given.

[Central hemodynamics in pulmonary tuberculosis patients at reoperation]. / Sostoianie tsentral'noi gemodinamiki u ftiziopul'monologicheskikh bol'nykh pri povtornykh operatsiiakh.

Central hemodynamic parameters were studied in 12 phthisiopulmonological patients by integral rheography before, at the end, and 1, 2, 3, 7 days after surgery. Signs of cardiovascular failure with phenomena of "blood flow centralization" were revealed. With intensive care, these hemodynamic changes were most prominent on days 1, 2, and 3 after surgery and hemodynamic improvement occurred on day 7.

[Effects of ftorotan and isoflurane on homeostatic parameters in patients with pulmonary tuberculosis ar reoperation]. / Vliianie ftorotana i izofliurana na pokazateli gomeostaza u ftiziopul'monologicheskikh bol'nykh pri povtornykh operatsiiakh.

Metabolic parameters were studied in 32 patients who underwent resurgery for complicated forms of pulmonary tuberculosis. Isoflurane caused deeper anesthesia than did ftorotan, exerted no toxic effect on hepatic function, did not alter the levels of serum immunoglobulins in the plasma of patients in the early postoperative period, which allows it to be recommended for its use in this group of patients.

[Sorption of aminoglycoside antibiotics from unfiltered culture fluid]. / Sorbtsiia antibiotikov-aminoglikozidov iz nefil'trovannoi kul'tural'noi zhidkosti.

Sorption of aminoglycosides such as sisomicin, gentamicin, kanamycin and streptomycin from the non-filtrated fermentation broth by carboxylic cation exchange resins under the static conditions was studied. The optimal conditions for the sorption of the aminoglycosides and their subsequent desorption were determined (the ratio of the volumes of the sorbent and fermentation broth and the time of the sorption and desorption).

[Destabilization of emulsions during extraction of antibiotics from natural solutions]. / Destabilizatsiia émul'sii pri ékstraktsionnom izvlechenii antibiotikov iz nativnykh rastvorov..

Various means for changing the aggregative stability of emulsions in the system of benzylpenicillin fermentation broth filtrate and butyl acetate were tested. It was shown that the use of desemulgators was more efficient than the use of some means for removing the desemulgating admixtures. Moreover, addition of surface active substances after the preliminary thermocoagulation resulted in maximum decreasing of the emulsion aggregative stability.

[Comparative evaluation of stability of benzylpenicillin in acid media of natural solutions and in culture fluid]. / Sravnitel'naia otsenka ustoichivosti benzilpenitsillina v kislykh sredakh v nativnom rastvore i kul'tural'noi zhidkosti.

Inactivation of benzylpenicillin in real media i.e. fermentation broths and their filtrates was studied in comparison with the published data on inactivation of commercial benzylpenicillin in aqueous solutions as dependent on the medium pH and temperature. The lowest constant of benzylpenicillin inactivation was shown to be in the fermentation broths.

[Infusion-transfusion tactics in tubercular surgical patients in relation to the volume of surgical blood loss]. / Infuzionno-transfuzionnaia taktika u ftiziokhirurgicheskikh bol'nykh v zavisimosti ot ob"ema operatsionnoi krovopoteri.

Infusion-transfusion tactics were studied in 71 patients with pulmonary tuberculosis during surgery and after it. Hemostasis parameters have been determined at different periods after surgery. Blood transfusion was not performed in patients with surgical blood loss below 500 g. When surgical blood loss was 500 to 1000 g hemotransfusion volume was 40-50% of blood loss. When surgical blood loss was 1000 g the volume of blood substituting solutions exceeded blood loss 2.4-4 times; in massive blood loss it was 1.5 times more. For the first 24 hours after surgery the volume of infusion-transfusion therapy was maintained at the same level, with its decrease 48 and 72 hours later. Such tactics promoted a favourable clinical course of the postoperative period and stabilization of basic homeostasis parameters.

[Hemostatic changes in patients with pulmonary tuberculosis in the postoperative period in relation to the volume of surgical blood loss]. / Izmeneniia sostoianiia gemostaza u ftiziokhirurgicheskikh bol'nykh v posleoperatsionnom periode v zavisimosti ot ob''ema operatsionnoi krovopoteri.

Hemocoagulation changes were studied in 71 pulmonary tuberculosis patients in the postoperative period. Red blood parameters and graphic coagulogram were determined. A moderate hypercoagulation syndrome was found in patients with operative blood loss of 500 g in the early and immediate postoperative period. With a rise in the operative blood loss volume and hemodilution degree changes appeared indicating a tendency to hypocoagulation shifts. In patients having moderate blood loss (501-1500 g) the hypocoagulation syndrome was associated with dilution coagulopathy. In larger blood loss (over 1500 g) the hypocoagulation syndrome was aggravated both by hemodilution coagulopathy and the expenditure of blood coagulation factors with the increase in fibrinolytic blood activity. These cases require therapy aimed at the prevention and management of arising hemocoagulation disorders.

[Mathematical model of removal of impurities from antibiotic pastes]. / Matematicheskaia model' protsessa osvobozhdeniia past antibiotikov ot primesnykh veshchestv.

The process of antibiotic paste washing by repulpation in a solvent, as well as the process of replacing washing of antibiotic filter cakes was studied. This enabled to develop a mathematical model of the process of admixture removing from antibiotic pastes by successive repulpation and replacing washing. The model connects the initial admixture levels in pastes, the filter cake characteristics, the specification requirements to the drug quality and the technological parameters of the process. The results of the studies confirmed the model adequacy.

[Regional changes in circulation in response to stimulation of beta-adrenergic receptors with isoproterenol]. / Regionarnye izmeneniia krovoobrashcheniia pod vliianiem stimuliatsii beta-adrenergicheskikh retseptorov izoproterenolom.

The muscle and adrenal fractions of cardiac output increased after injection of isoproterenol. The relative blood flow increase in skeletal muscles was accompanied with the increase in regional by-pass blood flow. The latter or reduction in the vessel permeability were found in the lungs. The cardiac output fractions decreased in extensive areas of skin, brain, myocardium, internal organs of hepatic portal vein, kidneys, testicles. The signs of the blood flow increase were found in the brain, myocardium, liver. The relative blood volume decreased in the majority of internal organs and tissues while increasing in the liver.

[Calculated rates of the filtration of antibiotic suspensions in leaf filters with horizontal filtering elements]. / Raschetnye sootnosheniia dlia protsessa fil'tratsii suspenzii antibiotikov na listovykh fil'trakh s gorizontal'nymi fil'truiushchimi elementami.

A procedure for calculating sediment distribution on horizontal filtering elements of multileaf filters used for separation of antibiotic suspensions, as well as for calculation of the filtration time in such apparatus is described. The correlations derived on the basis of this procedure may be used for preliminary technological evaluation of the stage of suspension filtration in production of antibiotic powders for injection with the use of closed air-tight apparatus schemes including multileaf filters.

[Elimination of admixtures from antibiotic sediments during their treatment with solvents]. / Udalenie primesei iz osadkov antibiotikov pri obrabotke ikh rastvoriteliami.

A model for determination of the admixture concentration in the secondary mother solution was developed. The concentration was determined depending on the solvent volume used for repulping the precipitate and on the impurity level of the initial antibiotic paste. When the values of X1 and X2 are known it is possible to estimate the amount of the admixtures remaining in the paste layer after separation of the secondary mother solution with regard to the volume of the latter in the precipitate pores. Optimization of paste repulping should be considered in combination with displacement washing and the apparatus used for separation of the phases, as well as the requirements for the purity level of the finished product.