ABSTRACT
AIM: To estimate central (aortic) blood pressure (BP) and arterial stiffness and their prognostic value in the development of preeclampsia (PE) in pregnant women with different forms of hypertension. SUBJECTS AND METHODS: The study included 106 patients with chronic hypertension, 21 with the latter concurrent with PE, 63 with gestational hypertension, 10 with PE, and 100 without hypertension. All the women underwent 24-hour BP monitoring by an oscillometric method to estimatecentral (aortic) BP and arterial stiffness at 16-22 weeks' gestation. RESULTS: The highest average daily central systolic and diastolic BP was in the pregnant women with PE. ROC analysis showed that the average daily aortic systolic BP greater than 115 mm Hg was most significant for the prediction of PE. The highest values of arterial stiffness (augmentation index, stiffness, maximum rate of blood pressure rise) were detected in the pregnant women with PE in the presence of chronic hypertension. CONCLUSION: 24-four BP monitoring inpregnant women can provide additional characteristics that reflect the stiffness of the aorta and peripheral arteries, which may be used to predict PE.
Subject(s)
Arterial Pressure/physiology , Hypertension/diagnosis , Pre-Eclampsia/diagnosis , Pregnancy Complications, Cardiovascular/diagnosis , Vascular Stiffness/physiology , Adult , Female , Humans , Pregnancy , Prognosis , Young AdultABSTRACT
AIM: To assess of the relationship of clinical and molecular genetic factors in the course and outcome of pregnancy in different forms of hypertension in pregnant women. PATIENTS AND METHODS: A total of 125 pregnant women who were divided into the following groups: with chronic hypertension (n = 45), with gestational hypertension (n = 20), with pre-eclampsia (n = 10), superimposed preeclampsia upon chronic hypertension (n = 15) and 35 women without hypertension in control group. RESULTS: In pregnant women with chronic hypertension and superimposed preeclampsia upon chronic hypertension were observed higher incidence of overweight and obesity, smoking before pregnancy and family history of hypertension and thrombosis, the course and outcomes of pregnancy characterized by higher frequency of obstetric complications, higher frequency of polymorphisms of genes identified the renin-angiotensin system, folate cycle and endothelial function. CONCLUSIONS: Molecular-genetic factors, combined with the factors of cardiovascular risk may make some contribution to the phenotypic realization of pregnancy complications and adverse pregnancy outcomes in pregnant women with different forms of hypertension.
Subject(s)
Genetic Markers/genetics , Hypertension/genetics , Medical History Taking/methods , Pregnancy Complications, Cardiovascular/genetics , Adolescent , Adult , Female , Follow-Up Studies , Humans , Hypertension/diagnosis , Hypertension/metabolism , Middle Aged , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/metabolism , Pregnancy Outcome , Prospective Studies , Risk Factors , Young AdultABSTRACT
The conditions of vascular thrombocyte, coagulator and fibrinolytic components of hemostasis were evaluated in trimestral dynamics in 65 healthy pregnant women without thrombotic risk factors and with physiologically progressing pregnancy resulted in timely delivery of term fetus. In the process of gestation, the increase of spontaneous and induced aggregative activity of thrombocytes, the increase of levels of fibrinogen, soluble fibrin monomeric complexes. D-dimer and fibrinolysis delay were established.
Subject(s)
Antithrombin III/analysis , Blood Platelets/cytology , Fibrinogen/analysis , Platelet Count , Adult , Female , Humans , Platelet Aggregation , PregnancySubject(s)
Heart Failure/prevention & control , Myocardial Infarction/drug therapy , Myocardium/metabolism , Animals , Aprotinin/therapeutic use , Ascorbic Acid/therapeutic use , Drug Therapy, Combination , Glutamates/therapeutic use , Glutamic Acid , Ibuprofen/therapeutic use , Nandrolone/analogs & derivatives , Nandrolone/therapeutic use , Nandrolone Decanoate , Nifedipine/therapeutic use , Potassium Magnesium Aspartate/therapeutic use , Propranolol/therapeutic use , Rabbits , Sodium Oxybate/therapeutic use , Vitamin E/therapeutic useSubject(s)
Monocytes/immunology , Myocardial Infarction/immunology , Phagocytosis , Animals , Humans , Leukocyte Count , Rabbits , Time FactorsABSTRACT
The paper concerns the basic parameters of GABA metabolism in 4 groups of animals: after emotional pain stress; after twofold administration of formalin; after coronary artery ligation; after narrowing of the aorta ostium. GABA metabolism in all brain systems was shown to be activated in all types of exposure to stress. One of the final GABA metabolites, hydroxybutyric acid, prevents undue enhancement of pituitary-adrenal function and injury to the internal organs during stress. This suggests that the GABA-ergic system plays the role of a nonspecific inhibitory mechanism that limits the stress-syndrome and averts stress injuries under exposure of the body to various extreme factors.
