ABSTRACT
Targeted effects of magnetic nanoparticles were studied. Solution with iron-containing nanosubstance was applied to resected nasal bone and cartilage tissues. Magnetic field was generated by a Polus-101 device for low-frequency magnetotherapy, which provided permanent work of one inductor (10.14+/-19.56 mT). The results indicate that magnetic nanoparticles placed into magnetic field gradient penetrate into the thickness of the cartilage and bone tissues.
Subject(s)
Electromagnetic Fields , Magnetics , Metal Nanoparticles/administration & dosage , Bone and Bones/metabolism , Cartilage/metabolism , Humans , Iron/chemistry , Metal Nanoparticles/chemistryABSTRACT
The objective of this study was to assess the appropriateness of using local antibacterial therapy in the postoperative period following rhinosurgical interventions based on the results of hemiluminescent, microbiological, and cytological studies. They included 20 patients who had underwent surgical intervention in the nasal cavity. The control group comprised 20 healthy subjects. The early postoperative period was characterized by a rise in the number and activity of neutrophilic granulocytes in blood and nasal mucosa along with a substantial increase of the abundance of bacterial flora in the nasal cavity. This suggests the necessity of local antibacterial therapy during the postoperative period following rhinosurgical interventions. Bioparox (fusafungine) spray is recommended as the optimal antibacterial preparation for the purpose by virtue of its broad spectrum of antimicrobial activity and strong anti-inflammatory action. Bioparox has an advantage over other sprays and aerosols in terms of pharmacokinetic characteristics.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Postoperative Care/methods , Rhinoplasty/methods , Surgical Wound Infection/prevention & control , Administration, Topical , Adolescent , Adult , Aerosols , Follow-Up Studies , Humans , Middle Aged , Treatment Outcome , Wound Healing/drug effects , Young AdultABSTRACT
The literature review of the methods for application of magnetic nanoparticles in different fields of medicine is presented. The paper summarizes the 40 year-long experience of Russian and foreign scientists with the use of magnetic suspensions, liquids, and particles with magnetic carriers from 10 to 1000 nm in diameter. Results of recent studies are presented, prospects for the development and application of nanomedical techniques in otorhinolaringology are discussed.
Subject(s)
Magnetics/methods , Metal Nanoparticles , Otolaryngology/methods , Otorhinolaryngologic Diseases/therapy , Animals , HumansABSTRACT
The objective of this study was to evaluate results of the new therapeutic modality for the management of chronic neurosensory loss of hearing based on the use of caviton. The open randomized study involved 50 patients. Criteria for the efficiency of therapy included the patients' complaints, self-evaluation of tympanophonia based on the visual-analogous scale, results of audiologic examination and Doppler ultrasound of carotid and vertebral arteries. Significant improvement of audiologic characteristics was documented in 80% of the patients; ultrasound examination showed that most of them tended to benefit from caviton therapy and reported reduction of tympanophonia. It is concluded that the new caviton dosing scheme for the treatment of neurosecretory loss of hearing is well tolerated by the patients and can be recommended for more extensive clinical application.
