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1.
Br J Dermatol ; 173(4): 940-8, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26036329

ABSTRACT

BACKGROUND: Norway spruce (Picea abies) produces resin to protect against decomposition by microbial pathogens. In vitro tests have shown that spruce resin has antifungal properties against dermatophytes known to cause nearly 90% of onychomycosis in humans. OBJECTIVES: To confirm previous in vivo observations that a topical resin lacquer provides mycological and clinical efficacy, and to compare this lacquer with topical amorolfine hydrochloride lacquer and systemic terbinafine for treating dermatophyte toenail onychomycosis. METHODS: In this prospective, randomized, controlled, investigator-blinded study, 73 patients with onychomycosis were randomized to receive topical 30% resin lacquer once daily for 9 months, topical 5% amorolfine lacquer once weekly for 9 months, or 250 mg oral terbinafine once daily for 3 months. The primary outcome measure was complete mycological cure at 10 months. Secondary outcomes were clinical efficacy, cost-effectiveness and patient compliance. RESULTS: At 10 months, complete mycological cure rates with the resin, amorolfine and terbinafine treatments were 13% [95% confidence interval (CI) 0-28], 8% (95% CI 0-19) and 56% (95% CI 35-77), respectively (P ≤ 0·002). At 10 months, clinical responses were complete in four patients (16%) treated with terbinafine, and partial in seven (30%), seven (28%) and nine (36%) patients treated with resin, amorolfine and terbinafine, respectively (P < 0·05). Resin, amorolfine and terbinafine treatments cost €41·6, €56·3 and €52·1, respectively, per patient (P < 0·001). CONCLUSIONS: Topical 30% resin lacquer and topical 5% amorolfine lacquer provided similar efficacy for treating dermatophyte toenail onychomycosis. However, orally administered terbinafine was significantly more effective in terms of mycological cure and clinical outcome than either topical therapy at the 10-month follow-up.


Subject(s)
Antifungal Agents/administration & dosage , Foot Dermatoses/drug therapy , Lacquer , Morpholines/administration & dosage , Naphthalenes/administration & dosage , Onychomycosis/drug therapy , Resins, Plant/administration & dosage , Administration, Oral , Administration, Topical , Adult , Antifungal Agents/adverse effects , Drug Administration Schedule , Drug Therapy, Combination , Female , Humans , Male , Morpholines/adverse effects , Naphthalenes/adverse effects , Prospective Studies , Resins, Plant/adverse effects , Single-Blind Method , Terbinafine , Treatment Outcome , Young Adult
2.
Eur J Clin Microbiol Infect Dis ; 31(8): 1783-9, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22179415

ABSTRACT

Resins (rosin, pitch) are natural products of the coniferous trees and are antimicrobial against a wide range of microbes. The antifungal effectiveness of resin, purified from Norway spruce (Picea abies), was studied against human pathogenic fungi and yeasts with the agar plate diffusion tests and electron microscopy (EM). The fungistatic effect of these resin mixtures (resin salves) was tested against a set of Candida yeasts, dermatophytes, and opportunistic fungi. Transmission and scanning EM was done from samples of fungi (Trichophyton mentagrophytes). In agar diffusion tests, the resin was strongly antifungal against all dermatophytes tested, e.g., against all fungi of the genus Trichophyton, but it was not antifungal against the Candida yeasts or against the opportunistic fungi tested. According to EM, resin caused damages in the cell hyphae and cell wall structures. We conclude that, in the agar plate diffusion test, coniferous resins are strongly fungistatic against the dermatophytic fungi only.


Subject(s)
Antifungal Agents/pharmacology , Fungi/drug effects , Picea/chemistry , Resins, Plant/pharmacology , Agar , Antifungal Agents/isolation & purification , Cell Wall/drug effects , Culture Media/chemistry , Fungi/growth & development , Fungi/ultrastructure , Humans , Hyphae/drug effects , Microbial Sensitivity Tests , Microscopy, Electron, Scanning , Microscopy, Electron, Transmission , Norway , Resins, Plant/isolation & purification
3.
J Wound Care ; 19(3): 123-7, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20559190

ABSTRACT

A vast range of dressings can be used on pressure ulcers, but despite this and the high expense often involved, there is no gold standard for the local treatment of these wounds. This literature review therefore set out to examine the evidence.


Subject(s)
Bandages , Pressure Ulcer/therapy , Bandages, Hydrocolloid , Biological Therapy/methods , Dermatologic Agents/therapeutic use , Evidence-Based Medicine , Humans , Pressure Ulcer/pathology
4.
Br J Dermatol ; 158(5): 1055-62, 2008 May.
Article in English | MEDLINE | ID: mdl-18284391

ABSTRACT

BACKGROUND: Resin salve of the Norway spruce (Picea abies) has been used in folk medicine to heal wounds and infections. OBJECTIVES: To study its clinical effectiveness in the treatment of pressure ulcers of the skin. METHODS: A prospective, randomized, controlled multicentre trial involving 37 patients with grade II-IV pressure ulcers in 11 primary care hospitals was carried out between 2005 and 2007. The ulcers were randomly allocated to receive either resin salve or sodium carboxymethylcellulose hydrocolloid polymer treatment. The inclusion criterion was grade II-IV pressure ulcer. Exclusion criteria were a life expectancy of less than 6 months or a malignant disease. The primary outcome measure was complete healing of the ulcer within 6 months. Secondary outcome measures were partial healing of the ulcer, and successful eradication of bacterial strains cultured from the ulcers at study entry. RESULTS: Thirteen patients of the resin group and nine patients of the control group completed the 6-month trial. All ulcers healed in 12 of the 13 patients (92%) in the resin group and in four of the nine patients (44%) in the control group (P=0.003; power 73%). Complete healing of the ulcers over time was significantly more common in the resin group than in the control group (P=0.013). Bacterial cultures from the ulcer area more often became negative within 1 month in the resin group. CONCLUSIONS: Traditional resin salve is significantly more effective in the treatment of infected and noninfected severe pressure ulcers than cellulose polymer gauzes.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Phytotherapy , Picea , Pressure Ulcer/drug therapy , Resins, Plant/therapeutic use , Aged , Aged, 80 and over , Female , Gram-Negative Bacteria/isolation & purification , Gram-Positive Bacteria/isolation & purification , Humans , Male , Middle Aged , Plant Preparations/therapeutic use , Pressure Ulcer/microbiology , Prospective Studies , Wound Healing
5.
APMIS ; 115(4): 335-40, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17504300

ABSTRACT

Resin salve made from Norway spruce (Picea abies) is traditionally used in folk medicine to heal skin ulcers and infected wounds. Its antimicrobial properties were studied against certain human bacteria important in infected skin wounds. The sensitivity of the resin against Gram-positive and Gram-negative bacteria was studied in vitro by methods that are routinely used in microbiology laboratories. The resin salve exhibited a bacteriostatic effect against all tested Gram-positive bacteria but only against Proteus vulgaris of the Gram-negative bacteria. Interestingly, the resin inhibited the growth of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE), both on agar plates and in culture media. The study demonstrated antimicrobial activity of the resin salve and provided objective evidence of its antimicrobial properties. It gives some explanations why the traditional use of home-made resin salve from Norway spruce is experienced as being effective in the treatment of infected skin ulcers.


Subject(s)
Anti-Bacterial Agents/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Picea/chemistry , Resins, Plant/pharmacology , Anti-Bacterial Agents/isolation & purification , Resins, Plant/isolation & purification
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